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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 82(2)

Influence of human adipose stem cells on prostate cancer cell growth

https://doi.org/10.18999/nagjms.82.2.217
https://doi.org/10.18999/nagjms.82.2.217
ad70b7bd-6eb9-4f87-9463-c8c344add5ef
名前 / ファイル ライセンス アクション
07_Yamamoto.pdf 07_Yamamoto.pdf (908.2 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2020-06-01
タイトル
タイトル Influence of human adipose stem cells on prostate cancer cell growth
著者 Yamamoto, Tokunori

× Yamamoto, Tokunori

WEKO 99272

Yamamoto, Tokunori

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Gotoh, Momokazu

× Gotoh, Momokazu

WEKO 99273

Gotoh, Momokazu

Search repository
Koide, Naoshi

× Koide, Naoshi

WEKO 99274

Koide, Naoshi

Search repository
Funahashi, Yasuhito

× Funahashi, Yasuhito

WEKO 99275

Funahashi, Yasuhito

Search repository
Shimizu, Shinobu

× Shimizu, Shinobu

WEKO 99276

Shimizu, Shinobu

Search repository
Takei, Yoshifumi

× Takei, Yoshifumi

WEKO 99277

Takei, Yoshifumi

Search repository
キーワード
主題Scheme Other
主題 adipose stem cells
キーワード
主題Scheme Other
主題 prostate cancer
キーワード
主題Scheme Other
主題 cell growth
抄録
内容記述 In a novel regenerative cell-based treatment developed by us for the patients with stress urinary incontinence, autologous adipose-derived stem cells (ASCs) are injected into the periurethral region and the external urethral sphincter. Since the candidates for this treatment included prostate cancer patients after radical prostatectomy, we investigated the effects of ASCs on prostate cancer cell proliferation in vitro and in vivo to confirm the feasibility of our therapeutic approach. The LNCaP (human prostate cancer cell line) cells and ASCs were co-cultured, and prostate-specific antigen (PSA) concentration in their culture medium supernatant was measured at 48 and 96 h. The PSA concentration significantly decreased in the coculture medium supernatant as compared to the culture medium with LNCaP cells alone. On the contrary, PSA concentrations in the culture medium of LNCaP cells were not affected by supplementation with ASC culture supernatant. After subcutaneous transplantation of LNCaP cells, with or without ASCs, in immunodeficient mice, tumor growth was compared. The growth of LNCaP xenograft tumor in immunodeficient mice was significantly suppressed by ASC addition. These results indicated that ASCs inhibit prostate cancer cell growth, without no proliferative effect on prostate cancer cells.
内容記述タイプ Abstract
内容記述
内容記述 This study was supported by a grant from the Japan Agency for Medical Research and Development (17bk0104057h0002).
内容記述タイプ Other
出版者
出版者 Nagoya University Graduate School of Medicine, School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.82.2.217
ID登録タイプ JaLC
関連情報
関連タイプ isVersionOf
識別子タイプ URI
関連識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/822.html
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
ISSN(Online)
収録物識別子タイプ ISSN
収録物識別子 2186-3326
書誌情報 Nagoya Journal of Medical Science

巻 82, 号 2, p. 217-224, 発行日 2020-05
著者版フラグ
値 publisher
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