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Transcription Factor Sox4 as a Potential Player in Mammary Gland Involution
http://hdl.handle.net/2237/00032519
http://hdl.handle.net/2237/00032519ed457871-98bc-432d-a4ce-6e1983ab412d
名前 / ファイル | ライセンス | アクション |
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Sox4-201910-op (1.8 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-07-16 | |||||
タイトル | ||||||
タイトル | Transcription Factor Sox4 as a Potential Player in Mammary Gland Involution | |||||
言語 | en | |||||
著者 |
Shibayama, Hirohisa
× Shibayama, Hirohisa× Yamamoto, Tomomi× Oshima, Kenzi× Matsuda, Tsukasa× Nadano, Daita |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
権利 | ||||||
言語 | en | |||||
権利情報 | “Final publication is available from Mary Ann Liebert, Inc., publishers http://dx.doi.org/10.1089/dna.2019.4700”. | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | mammalian development | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | mammary gland involution | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | gene expression | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | transcriptional control | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Sox4 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | cancer | |||||
抄録 | ||||||
内容記述 | Mammary gland involution is a regressive process for the gland to return to its prepregnancy state after lactation and comprises an initial reversible and second remodeling stage. Although many genes and the multiple expression profiles of their mRNAs have been found in this process, the mechanisms controlling the profiles are largely unknown. In this study, we identified and analyzed transcription factor Sox4 in mammary gland involution. Elevated expression of Sox4 gene in the first stage (48 h after weaning) was observed at the mRNA and protein levels in the mouse mammary gland. Immunohistochemistry of the involuting gland indicated that Sox4 was located in the nuclei of epithelial cells. Nuclear Sox4 was also detected in the second stage, but unlikely to be involved in cell death, one of the characteristic events of involution. To clarify the functional roles of Sox4 in involution, we introduced a model, including a normal mammary epithelial cell line, for finding candidate target genes of this transcription factor and examined its effect on tenascin C mRNA expression. | |||||
言語 | en | |||||
内容記述タイプ | Abstract | |||||
内容記述 | ||||||
内容記述 | ファイル公開:2020/10/07 | |||||
言語 | ja | |||||
内容記述タイプ | Other | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | Mary Ann Liebert | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプresource | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1089/dna.2019.4700 | |||||
ISSN(print) | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 1044-5498 | |||||
書誌情報 |
en : DNA and Cell Biology 巻 38, 号 10, p. 1125-1133, 発行日 2019-10-07 |
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著者版フラグ | ||||||
値 | author |