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  1. B300 農学部/生命農学研究科
  2. B300a 雑誌掲載論文
  3. 学術雑誌

Transcription Factor Sox4 as a Potential Player in Mammary Gland Involution

http://hdl.handle.net/2237/00032519
ed457871-98bc-432d-a4ce-6e1983ab412d
名前 / ファイル ライセンス アクション
Sox4-201910-op.pdf Sox4-201910-op (1.8 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2020-07-16
タイトル
タイトル Transcription Factor Sox4 as a Potential Player in Mammary Gland Involution
著者 Shibayama, Hirohisa

× Shibayama, Hirohisa

WEKO 100630

Shibayama, Hirohisa

Search repository
Yamamoto, Tomomi

× Yamamoto, Tomomi

WEKO 100631

Yamamoto, Tomomi

Search repository
Oshima, Kenzi

× Oshima, Kenzi

WEKO 100632

Oshima, Kenzi

Search repository
Matsuda, Tsukasa

× Matsuda, Tsukasa

WEKO 100633

Matsuda, Tsukasa

Search repository
Nadano, Daita

× Nadano, Daita

WEKO 100634

Nadano, Daita

Search repository
権利
権利情報 “Final publication is available from Mary Ann Liebert, Inc., publishers http://dx.doi.org/10.1089/dna.2019.4700”.
キーワード
主題Scheme Other
主題 mammalian development
キーワード
主題Scheme Other
主題 mammary gland involution
キーワード
主題Scheme Other
主題 gene expression
キーワード
主題Scheme Other
主題 transcriptional control
キーワード
主題Scheme Other
主題 Sox4
キーワード
主題Scheme Other
主題 cancer
抄録
内容記述 Mammary gland involution is a regressive process for the gland to return to its prepregnancy state after lactation and comprises an initial reversible and second remodeling stage. Although many genes and the multiple expression profiles of their mRNAs have been found in this process, the mechanisms controlling the profiles are largely unknown. In this study, we identified and analyzed transcription factor Sox4 in mammary gland involution. Elevated expression of Sox4 gene in the first stage (48 h after weaning) was observed at the mRNA and protein levels in the mouse mammary gland. Immunohistochemistry of the involuting gland indicated that Sox4 was located in the nuclei of epithelial cells. Nuclear Sox4 was also detected in the second stage, but unlikely to be involved in cell death, one of the characteristic events of involution. To clarify the functional roles of Sox4 in involution, we introduced a model, including a normal mammary epithelial cell line, for finding candidate target genes of this transcription factor and examined its effect on tenascin C mRNA expression.
内容記述タイプ Abstract
内容記述
内容記述 ファイル公開:2020/10/07
内容記述タイプ Other
出版者
出版者 Mary Ann Liebert
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1089/dna.2019.4700
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 1044-5498
書誌情報 DNA and Cell Biology

巻 38, 号 10, p. 1125-1133, 発行日 2019-10-07
著者版フラグ
値 author
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