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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 82(3)

Hydrocolloid dressing improves wound healing by increasing M2 macrophage polarization in mice with diabetes

https://doi.org/10.18999/nagjms.82.3.487
https://doi.org/10.18999/nagjms.82.3.487
fe5644d5-9d1c-4b34-a449-940ff6c9ddda
名前 / ファイル ライセンス アクション
11_Takeuchi.pdf 11_Takeuchi.pdf (44.9 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2020-09-04
タイトル
タイトル Hydrocolloid dressing improves wound healing by increasing M2 macrophage polarization in mice with diabetes
著者 Takeuchi, Tamaki

× Takeuchi, Tamaki

WEKO 101056

Takeuchi, Tamaki

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Ito, Morihiro

× Ito, Morihiro

WEKO 101057

Ito, Morihiro

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Yamaguchi, Seiji

× Yamaguchi, Seiji

WEKO 101058

Yamaguchi, Seiji

Search repository
Watanabe, Saki

× Watanabe, Saki

WEKO 101059

Watanabe, Saki

Search repository
Honda, Masashi

× Honda, Masashi

WEKO 101060

Honda, Masashi

Search repository
Imahashi, Takuya

× Imahashi, Takuya

WEKO 101061

Imahashi, Takuya

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Yamada, Tsuyoshi

× Yamada, Tsuyoshi

WEKO 101062

Yamada, Tsuyoshi

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Kokubo, Tadashi

× Kokubo, Tadashi

WEKO 101063

Kokubo, Tadashi

Search repository
キーワード
主題Scheme Other
主題 hydrocolloid dressing
キーワード
主題Scheme Other
主題 wound healing
キーワード
主題Scheme Other
主題 M2 macrophage
キーワード
主題Scheme Other
主題 diabetic mice
抄録
内容記述 Impaired wound healing is one of the most common complications of diabetes, and is known to be caused by multiple complicated factors. For instance, impaired angiogenesis, neuropathy, and hyperglycemia all function to delay subsequent wound closure. Alternatively, moist wound healing, which provides an appropriate environment for wounds, was reported to permit rapid healing by managing wound exudate. Accordingly, wound dressing materials that facilitate moist healing have been developed. The present study sought to clarify the effects of wound dressing material for moist healing of diabetic wounds, in terms of the dynamics of angiogenic factors and macrophages, using a mouse model of naturally occurring diabetes. Wounds with full-thickness skin defects were inflicted on the backs of mice and covered with dressing materials of hydrogel or gauze (control), which were retained for 3, 5, 7, 10, or 14 days following wound generation. During this time, the localization of neutrophils, fibroblasts and macrophages as well as the expression of vascular endothelial growth factor (VEGF) in the wounds and surrounding areas was observed each day. Healing clearly occurred in the hydrogel group with an increase in neutrophils and the angiogenic factor, VEGF. Moreover, the use of hydrogel resulted in a rapid rise in M1 macrophages, which appeared in the early stage of the injury, as well as rapid subsequent appearance of M2 macrophages. Thus, herein, we demonstrate that the formation of a moist environment via wound dressing material effectively improves diabetic wound healing.
内容記述タイプ Abstract
出版者
出版者 Nagoya University Graduate School of Medicine, School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.82.3.487
ID登録タイプ JaLC
関連情報
関連タイプ isVersionOf
識別子タイプ URI
関連識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/823.html
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
ISSN(Online)
収録物識別子タイプ ISSN
収録物識別子 2186-3326
書誌情報 Nagoya Journal of Medical Science

巻 82, 号 3, p. 487-498, 発行日 2020-08
著者版フラグ
値 publisher
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