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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 82(3)

Serum surfactant protein A as a surrogate biomarker of a negative heart sign among patients with interstitial lung disease

https://doi.org/10.18999/nagjms.82.3.499
https://doi.org/10.18999/nagjms.82.3.499
c5d826a4-ad6d-48e5-87f0-a5b1c0e6c644
名前 / ファイル ライセンス アクション
12_Sasaki.pdf 12_Sasaki.pdf (7.2 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2020-09-04
タイトル
タイトル Serum surfactant protein A as a surrogate biomarker of a negative heart sign among patients with interstitial lung disease
著者 Sasaki, Hisashi

× Sasaki, Hisashi

WEKO 101064

Sasaki, Hisashi

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Hara, Yu

× Hara, Yu

WEKO 101065

Hara, Yu

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Taguri, Masataka

× Taguri, Masataka

WEKO 101066

Taguri, Masataka

Search repository
Fujikura, Yuji

× Fujikura, Yuji

WEKO 101067

Fujikura, Yuji

Search repository
Murohashi, Kota

× Murohashi, Kota

WEKO 101068

Murohashi, Kota

Search repository
Yagyu, Hiroyuki

× Yagyu, Hiroyuki

WEKO 101069

Yagyu, Hiroyuki

Search repository
Kaneko, Takeshi

× Kaneko, Takeshi

WEKO 101070

Kaneko, Takeshi

Search repository
Kawana, Akihiko

× Kawana, Akihiko

WEKO 101071

Kawana, Akihiko

Search repository
キーワード
主題Scheme Other
主題 inflammation
キーワード
主題Scheme Other
主題 idiopathic pulmonary fibrosis
キーワード
主題Scheme Other
主題 surfactant protein
キーワード
主題Scheme Other
主題 treatment
キーワード
主題Scheme Other
主題 gallium uptake
抄録
内容記述 The mechanisms underlying interstitial lung disease (ILD) are characterized by variable inflammation or fibrosis of the pulmonary interstitium. A negative heart sign (NHS) on 67Ga scintigrams of patients with ILD is due to considerably increased inflammatory activity in the lungs. We retrospectively analyzed relationships between NHS and established biomarkers of disease severity in patients with ILD. Among 81 consecutive non-smoking patients with ILD (mean age, 63 years) who had been hospitalized between April 2009 and October 2011, we selected 52 who had been assessed by 67Ga scintigraphy. We then evaluated relationships between NHS and blood biomarkers, pulmonary function and high-resolution computed tomography (HRCT). Among these 52 patients, 10 showed idiopathic pulmonary fibrosis and 42 had other ILD. Multivariate analysis with stepwise variable selection, serum surfactant protein (SP)-A (OR (odds ratio), 1.026; 95%CI (confidence interval), 1.003–1.050; P = 0.024) and inflammation index calculated from HRCT findings (OR, 1.358; 95%CI, 1.079–1.709; P = 0.009) were significant predictors of an NHS. Serum SP-A offered 85% sensitivity and 75% specificity for predicting NHS at an optimal cut-off of 45.8 ng/mL. Serum SP-A concentrations correlated positively with inflammation index (r = 0.344, P = 0.015). In conclusion, serum SP-A might serve as a surrogate biomarker for predicting an NHS in patients with ILD.
内容記述タイプ Abstract
出版者
出版者 Nagoya University Graduate School of Medicine, School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.82.3.499
ID登録タイプ JaLC
関連情報
関連タイプ isVersionOf
識別子タイプ URI
関連識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/823.html
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
ISSN(Online)
収録物識別子タイプ ISSN
収録物識別子 2186-3326
書誌情報 Nagoya Journal of Medical Science

巻 82, 号 3, p. 499-508, 発行日 2020-08
著者版フラグ
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