{"_buckets": {"deposit": "58c9c531-8661-4864-9b28-6a597c4d0c47"}, "_deposit": {"id": "30423", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "30423"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00030423"}, "item_9_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2020-08", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "3", "bibliographicPageEnd": "543", "bibliographicPageStart": "533", "bibliographicVolumeNumber": "82", "bibliographic_titles": [{"bibliographic_title": "Nagoya Journal of Medical Science"}]}]}, "item_9_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "This study aimed to identify the elderly generation with the worst prognoses for high-grade astrocytoma and find independent predictors of good outcomes. We conducted a retrospective analysis of 91 patients, \u226565 years old, with anaplastic astrocytoma or glioblastoma. Progression-free survival (PFS) and overall survival (OS) were calculated using the Kaplan\u2013Meier method and compared using log-rank test or multivariate Cox regression analysis. We included 21 (23%) and 70 (77%) patients aged 65\u201369 years and \u226570 years. In the two generations, significant differences were found in the Charlson comorbidity index, extent of resection, chemoradiotherapy (CRT) as adjuvant therapy, and radiation dose (all P \u003c 0.05). The median PFS was 9.9 and 6.9 months in patients aged 65\u201369 and \u226570 years (P = 0.10). The median OS was 22.8 and 11.6 months in patients aged 65\u201369 and \u226570 years (P = 0.009). In the multivariate analyzes in patients \u226570 years, only postoperative Karnofsky performance status (KPS) scores \u226570 were significantly related to prolonged PFS (hazard ratio [HR]: 0.48, P = 0.04), and postoperative KPS, CRT as adjuvant therapy, and salvage therapy were significantly related to prolonged OS (HR: 0.45, P = 0.03, HR: 0.38, P = 0.002, and HR: 0.43, P = 0.01, respectively). In conclusion, in patients \u226570 with high-grade astrocytoma, OS was significantly shorter compared to those aged 65\u201369. Postoperative KPS score was significantly related to prolonged PFS and OS. Postoperative CRT and salvage therapy at recurrence may be effective in the selected elderly.", "subitem_description_type": "Abstract"}]}, "item_9_identifier_registration": {"attribute_name": "ID\u767b\u9332", "attribute_value_mlt": [{"subitem_identifier_reg_text": "10.18999/nagjms.82.3.533", "subitem_identifier_reg_type": "JaLC"}]}, "item_9_publisher_32": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Nagoya University Graduate School of Medicine, School of Medicine"}]}, "item_9_relation_43": {"attribute_name": "\u7570\u7248\u3067\u3042\u308b", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/823.html ", "subitem_relation_type_select": "URI"}}]}, "item_9_select_15": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_9_source_id_61": {"attribute_name": "ISSN\uff08Online\uff09", "attribute_value_mlt": [{"subitem_source_identifier": "2186-3326", "subitem_source_identifier_type": "ISSN"}]}, "item_9_source_id_7": {"attribute_name": "ISSN\uff08print\uff09", "attribute_value_mlt": [{"subitem_source_identifier": "0027-7622", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Deguchi, Shoichi"}], "nameIdentifiers": [{"nameIdentifier": "101094", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Mitsuya, Koichi"}], "nameIdentifiers": [{"nameIdentifier": "101095", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Oishi, Takuma"}], "nameIdentifiers": [{"nameIdentifier": "101096", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakasu, Yoko"}], "nameIdentifiers": [{"nameIdentifier": "101097", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sugino, Takashi"}], "nameIdentifiers": [{"nameIdentifier": "101098", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hayashi, Nakamasa"}], "nameIdentifiers": [{"nameIdentifier": "101099", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-09-04"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "15_Deguchi.pdf", "filesize": [{"value": "265.0 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 265000.0, "url": {"label": "15_Deguchi.pdf", "url": "https://nagoya.repo.nii.ac.jp/record/30423/files/15_Deguchi.pdf"}, "version_id": "259a7ebd-390d-4e29-a17f-50fee9f59a21"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "chemoradiotherapy", "subitem_subject_scheme": "Other"}, {"subitem_subject": "elderly", "subitem_subject_scheme": "Other"}, {"subitem_subject": "high-grade astrocytoma", "subitem_subject_scheme": "Other"}, {"subitem_subject": "postoperative KPS", "subitem_subject_scheme": "Other"}, {"subitem_subject": "salvage therapy", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Impact of maintenance of postoperative performance status on survival in elderly patients over 70 with high-grade astrocytoma", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Impact of maintenance of postoperative performance status on survival in elderly patients over 70 with high-grade astrocytoma"}]}, "item_type_id": "9", "owner": "1", "path": ["499/508/509/2518"], "permalink_uri": "https://doi.org/10.18999/nagjms.82.3.533", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_name_i18n": "\u516c\u958b\u65e5", "attribute_value": "2020-09-04"}, "publish_date": "2020-09-04", "publish_status": "0", "recid": "30423", "relation": {}, "relation_version_is_last": true, "title": ["Impact of maintenance of postoperative performance status on survival in elderly patients over 70 with high-grade astrocytoma"], "weko_shared_id": null}