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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 82(3)

Impact of maintenance of postoperative performance status on survival in elderly patients over 70 with high-grade astrocytoma

https://doi.org/10.18999/nagjms.82.3.533
https://doi.org/10.18999/nagjms.82.3.533
b1d22b64-9ddf-48c1-8159-bc7fbd6324ab
名前 / ファイル ライセンス アクション
15_Deguchi.pdf 15_Deguchi.pdf (265.0 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2020-09-04
タイトル
タイトル Impact of maintenance of postoperative performance status on survival in elderly patients over 70 with high-grade astrocytoma
著者 Deguchi, Shoichi

× Deguchi, Shoichi

WEKO 101094

Deguchi, Shoichi

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Mitsuya, Koichi

× Mitsuya, Koichi

WEKO 101095

Mitsuya, Koichi

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Oishi, Takuma

× Oishi, Takuma

WEKO 101096

Oishi, Takuma

Search repository
Nakasu, Yoko

× Nakasu, Yoko

WEKO 101097

Nakasu, Yoko

Search repository
Sugino, Takashi

× Sugino, Takashi

WEKO 101098

Sugino, Takashi

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Hayashi, Nakamasa

× Hayashi, Nakamasa

WEKO 101099

Hayashi, Nakamasa

Search repository
キーワード
主題Scheme Other
主題 chemoradiotherapy
キーワード
主題Scheme Other
主題 elderly
キーワード
主題Scheme Other
主題 high-grade astrocytoma
キーワード
主題Scheme Other
主題 postoperative KPS
キーワード
主題Scheme Other
主題 salvage therapy
抄録
内容記述 This study aimed to identify the elderly generation with the worst prognoses for high-grade astrocytoma and find independent predictors of good outcomes. We conducted a retrospective analysis of 91 patients, ≥65 years old, with anaplastic astrocytoma or glioblastoma. Progression-free survival (PFS) and overall survival (OS) were calculated using the Kaplan–Meier method and compared using log-rank test or multivariate Cox regression analysis. We included 21 (23%) and 70 (77%) patients aged 65–69 years and ≥70 years. In the two generations, significant differences were found in the Charlson comorbidity index, extent of resection, chemoradiotherapy (CRT) as adjuvant therapy, and radiation dose (all P < 0.05). The median PFS was 9.9 and 6.9 months in patients aged 65–69 and ≥70 years (P = 0.10). The median OS was 22.8 and 11.6 months in patients aged 65–69 and ≥70 years (P = 0.009). In the multivariate analyzes in patients ≥70 years, only postoperative Karnofsky performance status (KPS) scores ≥70 were significantly related to prolonged PFS (hazard ratio [HR]: 0.48, P = 0.04), and postoperative KPS, CRT as adjuvant therapy, and salvage therapy were significantly related to prolonged OS (HR: 0.45, P = 0.03, HR: 0.38, P = 0.002, and HR: 0.43, P = 0.01, respectively). In conclusion, in patients ≥70 with high-grade astrocytoma, OS was significantly shorter compared to those aged 65–69. Postoperative KPS score was significantly related to prolonged PFS and OS. Postoperative CRT and salvage therapy at recurrence may be effective in the selected elderly.
内容記述タイプ Abstract
出版者
出版者 Nagoya University Graduate School of Medicine, School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.82.3.533
ID登録タイプ JaLC
関連情報
関連タイプ isVersionOf
識別子タイプ URI
関連識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/823.html
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
ISSN(Online)
収録物識別子タイプ ISSN
収録物識別子 2186-3326
書誌情報 Nagoya Journal of Medical Science

巻 82, 号 3, p. 533-543, 発行日 2020-08
著者版フラグ
値 publisher
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