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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Glymphatic imaging using MRI

http://hdl.handle.net/2237/00032625
http://hdl.handle.net/2237/00032625
e4eb375f-b668-4779-bb20-5a67c8bb2cda
名前 / ファイル ライセンス アクション
Glymphatic_Imaging_using_MRI_Total_Final.pdf Glymphatic_Imaging_using_MRI_Total_Final (2.7 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2020-09-14
タイトル
タイトル Glymphatic imaging using MRI
言語 en
著者 Taoka, Toshiaki

× Taoka, Toshiaki

WEKO 101203

en Taoka, Toshiaki

Search repository
Naganawa, Shinji

× Naganawa, Shinji

WEKO 101204

en Naganawa, Shinji

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 This is the peer reviewed version of the following article: [Taoka, T. and Naganawa, S. (2020), Glymphatic imaging using MRI. J Magn Reson Imaging, 51: 11-24. doi:10.1002/jmri.26892], which has been published in final form at [https://doi.org/10.1002/jmri.26892]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
キーワード
主題Scheme Other
主題 glymphatic system
キーワード
主題Scheme Other
主題 cerebrospinal fluid
キーワード
主題Scheme Other
主題 interstitial fluid
キーワード
主題Scheme Other
主題 magnetic resonance imaging
キーワード
主題Scheme Other
主題 diffusion imaging
キーワード
主題Scheme Other
主題 contrast media
抄録
内容記述 In recent years, the existence of a mass transport system in the brain via cerebrospinal fluid (CSF) or interstitial fluid (ISF) has been suggested by many studies. The glymphatic system is hypothesized to be a waste clearance system of the CSF through the perivascular and interstitial spaces in the brain. Tracer studies have primarily been used to visualize or evaluate the waste clearance system in the brain, and evidence for this system has accumulated. The initial study that identified the glymphatic system was an in vivo tracer study in mice. In that study, fluorescent tracers were injected into the cisterna magna and visualized by two‐photon microscopy. MRI has also been used to evaluate glymphatic function primarily with gadolinium‐based contrast agents (GBCAs) as tracers. A number of GBCA studies evaluating glymphatic function have been conducted using either intrathecal or intravenous injections. Stable isotopes, such as 17O‐labeled water, may also be used as tracers since they can be detected by MRI. In addition to tracer studies, several other approaches have been used to evaluate ISF dynamics within the brain, including diffusion imaging. Phase contrast evaluation is a powerful method for visualizing flow within the CSF space. In order to evaluate the movement of water within tissue, diffusion‐weighted MRI represents another promising technique, and several studies have utilized diffusion techniques for the evaluation of the glymphatic system. This review will discuss the findings of these diffusion studies.
言語 en
内容記述タイプ Abstract
内容記述
内容記述 ファイル公開:2021-01-01
言語 ja
内容記述タイプ Other
出版者
言語 en
出版者 Wiley
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1002/jmri.26892
ISSN(print)
収録物識別子タイプ PISSN
収録物識別子 1053-1807
書誌情報 en : Journal of Magnetic Resonance Imaging

巻 51, 号 1, p. 11-24, 発行日 2020-01
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