{"_buckets": {"deposit": "f5005960-bf8b-42e6-b7b3-37f586ccdc25"}, "_deposit": {"id": "30440", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "30440"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00030440"}, "item_10_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2020-01", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageEnd": "24", "bibliographicPageStart": "11", "bibliographicVolumeNumber": "51", "bibliographic_titles": [{"bibliographic_title": "Journal of Magnetic Resonance Imaging"}]}]}, "item_10_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "In recent years, the existence of a mass transport system in the brain via cerebrospinal fluid (CSF) or interstitial fluid (ISF) has been suggested by many studies. The glymphatic system is hypothesized to be a waste clearance system of the CSF through the perivascular and interstitial spaces in the brain. Tracer studies have primarily been used to visualize or evaluate the waste clearance system in the brain, and evidence for this system has accumulated. The initial study that identified the glymphatic system was an in vivo tracer study in mice. In that study, fluorescent tracers were injected into the cisterna magna and visualized by two\u2010photon microscopy. MRI has also been used to evaluate glymphatic function primarily with gadolinium\u2010based contrast agents (GBCAs) as tracers. A number of GBCA studies evaluating glymphatic function have been conducted using either intrathecal or intravenous injections. Stable isotopes, such as 17O\u2010labeled water, may also be used as tracers since they can be detected by MRI. In addition to tracer studies, several other approaches have been used to evaluate ISF dynamics within the brain, including diffusion imaging. Phase contrast evaluation is a powerful method for visualizing flow within the CSF space. In order to evaluate the movement of water within tissue, diffusion\u2010weighted MRI represents another promising technique, and several studies have utilized diffusion techniques for the evaluation of the glymphatic system. This review will discuss the findings of these diffusion studies. ", "subitem_description_type": "Abstract"}]}, "item_10_description_5": {"attribute_name": "\u5185\u5bb9\u8a18\u8ff0", "attribute_value_mlt": [{"subitem_description": "\u30d5\u30a1\u30a4\u30eb\u516c\u958b\uff1a2021-01-01", "subitem_description_type": "Other"}]}, "item_10_publisher_32": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Wiley"}]}, "item_10_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1002/jmri.26892", "subitem_relation_type_select": "DOI"}}]}, "item_10_rights_12": {"attribute_name": "\u6a29\u5229", "attribute_value_mlt": [{"subitem_rights": "\"This is the peer reviewed version of the following article: [Taoka, T. and Naganawa, S. (2020), Glymphatic imaging using MRI. J Magn Reson Imaging, 51: 11-24. doi:10.1002/jmri.26892], which has been published in final form at [https://doi.org/10.1002/jmri.26892]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.\""}]}, "item_10_select_15": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_10_source_id_61": {"attribute_name": "ISSN\uff08print\uff09", "attribute_value_mlt": [{"subitem_source_identifier": "1053-1807", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Taoka, Toshiaki"}], "nameIdentifiers": [{"nameIdentifier": "101203", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Naganawa, Shinji"}], "nameIdentifiers": [{"nameIdentifier": "101204", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2021-01-01"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Glymphatic_Imaging_using_MRI_Total_Final.pdf", "filesize": [{"value": "2.7 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 2700000.0, "url": {"label": "Glymphatic_Imaging_using_MRI_Total_Final", "url": "https://nagoya.repo.nii.ac.jp/record/30440/files/Glymphatic_Imaging_using_MRI_Total_Final.pdf"}, "version_id": "430ae2fe-e29c-49b3-80f1-96b923e93bfa"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "glymphatic system", "subitem_subject_scheme": "Other"}, {"subitem_subject": "cerebrospinal fluid", "subitem_subject_scheme": "Other"}, {"subitem_subject": "interstitial fluid", "subitem_subject_scheme": "Other"}, {"subitem_subject": "magnetic resonance imaging", "subitem_subject_scheme": "Other"}, {"subitem_subject": "diffusion imaging", "subitem_subject_scheme": "Other"}, {"subitem_subject": "contrast media", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Glymphatic imaging using MRI", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Glymphatic imaging using MRI"}]}, "item_type_id": "10", "owner": "1", "path": ["499/500/501"], "permalink_uri": "http://hdl.handle.net/2237/00032625", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_name_i18n": "\u516c\u958b\u65e5", "attribute_value": "2020-09-14"}, "publish_date": "2020-09-14", "publish_status": "0", "recid": "30440", "relation": {}, "relation_version_is_last": true, "title": ["Glymphatic imaging using MRI"], "weko_shared_id": null}