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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Efficacy of low-dose chemotherapy with methotrexate and vinblastine for patients with extra-abdominal desmoid-type fibromatosis: a systematic review

http://hdl.handle.net/2237/00032644
http://hdl.handle.net/2237/00032644
9f4cf104-10a3-48e2-8179-40dffd891936
名前 / ファイル ライセンス アクション
manuscript.pdf manuscript (270.4 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2020-09-17
タイトル
タイトル Efficacy of low-dose chemotherapy with methotrexate and vinblastine for patients with extra-abdominal desmoid-type fibromatosis: a systematic review
言語 en
著者 Nishida, Yoshihiro

× Nishida, Yoshihiro

WEKO 101297

en Nishida, Yoshihiro

Search repository
Yoshida, Masahiro

× Yoshida, Masahiro

WEKO 101298

en Yoshida, Masahiro

Search repository
Koike, Hiroshi

× Koike, Hiroshi

WEKO 101299

en Koike, Hiroshi

Search repository
Sakai, Tomohisa

× Sakai, Tomohisa

WEKO 101300

en Sakai, Tomohisa

Search repository
Hamada, Shunsuke

× Hamada, Shunsuke

WEKO 101301

en Hamada, Shunsuke

Search repository
Shimizu, Koki

× Shimizu, Koki

WEKO 101302

en Shimizu, Koki

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 This is a pre-copyedited, author-produced version of an article accepted for publication in [Japanese Journal of Clinical Oncology] following peer review. The version of record [Japanese Journal of Clinical Oncology. v.50, n.4, 2020, p.419-424] is available online at: https://doi.org/10.1093/jjco/hyz204.
キーワード
主題Scheme Other
主題 desmoid-type fibromatosis
キーワード
主題Scheme Other
主題 systematic review
キーワード
主題Scheme Other
主題 chemotherapy
キーワード
主題Scheme Other
主題 methotrexate
キーワード
主題Scheme Other
主題 vinblastine
抄録
内容記述 Objective: The treatment modality for desmoid-type fibromatosis has shifted from surgery to conservative treatment. This systematic review aims to evaluate the efficacy of low-dose chemotherapy with methotrexate and vinblastine for patients with extra-abdominal desmoid-type fibromatosis. Methods: We searched the pertinent literature from January 1990 to August 2017. Two reviewers evaluated and screened the literature independently for eligibility and extracted data. We evaluated the quality of body of evidence and made a recommendation according to the Grading of Recommendations Development and Evaluation methodology. Results: The search yielded 40 studies, 9 of which were included after the first and second screenings. There were three prospective case series but no randomized controlled trials among the nine studies. There was no case–control report (vs. no treatment). According to Response Evaluation Criteria in Solid Tumors criteria, the mean response rate (complete remission or partial response) was 36% (11–57%). Including stable disease, namely, clinical benefit was consistently as high as 85% (69–100%). Mean adverse event rate of G3 or G4 according to CTCAE was 31%. One study reported improvement of pain (87.5%) because of this chemotherapy. Conclusion: The efficacy of this chemotherapy was convincing. However, the overall evidence was weak, and this chemotherapy is not covered by insurance in Japan; we only weakly recommend low-dose chemotherapy with methotrexate and vinblastine in patients with extra-abdominal desmoid-type fibromatosis.
言語 en
内容記述タイプ Abstract
内容記述
内容記述 ファイル公開日: 2020/10/01
言語 ja
内容記述タイプ Other
出版者
言語 en
出版者 Oxford University Press
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1093/jjco/hyz204
ISSN(print)
収録物識別子タイプ PISSN
収録物識別子 1465-3621
書誌情報 en : Japanese Journal of Clinical Oncology

巻 50, 号 4, p. 419-424, 発行日 2020-04
著者版フラグ
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