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Pivotal Role of Interdigitation in Interleaflet Interactions: Implications from Molecular Dynamics Simulations
http://hdl.handle.net/2237/00032719
http://hdl.handle.net/2237/00032719fca104e4-6b59-46db-b947-8d62980ef1eb
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
JPCL2020 (2.0 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-10-13 | |||||
| タイトル | ||||||
| タイトル | Pivotal Role of Interdigitation in Interleaflet Interactions: Implications from Molecular Dynamics Simulations | |||||
| 言語 | en | |||||
| 著者 |
Seo, Sangjae
× Seo, Sangjae× Murata, Michio× Shinoda, Wataru |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 権利 | ||||||
| 言語 | en | |||||
| 権利情報 | “This document is the Accepted Manuscript version of a Published Work that appeared in final form in [The Journal of Physical Chemistry Letters], copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see [https://pubs.acs.org/articlesonrequest/AOR-T9V5KKNRQCGKTINEMHX8].” | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Lipids | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Membranes | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Phase separation | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Acyls | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Order | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The asymmetric lipid composition in plasma membranes within the inner leaflet is not typically suitable for domain formation. Thus elucidation of the likelihood of the formation or stability of a raft-like domain in the inner leaflet is necessary. Herein we investigated the phase behavior of asymmetric membranes using coarse-grained molecular dynamics simulations. The lipid leaflet comprising dioleoylphosphatidylcholine (DOPC) and cholesterol (Chol) does not typically show well-developed domains in symmetric bilayer membranes; however, it does separate into liquid ordered (Lo) and liquid disordered (Ld) phases when the opposing leaflet containing sphingomyelin (SM), DOPC, and Chol demonstrates domain formation. We determine that interdigitated acyl chains modulated the partitioning of Chol in the opposing leaflet, resulting in phase separation. Similarly, the acyl chain length of SM within the opposing leaflet affected the phase behavior of the leaflet. Our results reveal the crucial role of interdigitation in determining the phase status in asymmetric membranes. | |||||
| 言語 | en | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | ファイル公開：2021-07-02 | |||||
| 言語 | ja | |||||
| 出版者 | ||||||
| 出版者 | ACS Publications | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 出版タイプ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1021/acs.jpclett.0c01317 | |||||
| ISSN（print） | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 1948-7185 | |||||
| 書誌情報 |
en : The Journal of Physical Chemistry Letters 巻 11, 号 13, p. 5171-5176, 発行日 2020-07-02 |
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| 著者版フラグ | ||||||
| 値 | author | |||||
