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Prospective evaluation of alternative donor from unrelated donor and cord blood in adult acute leukemia and myelodysplastic syndrome
http://hdl.handle.net/2237/00032726
http://hdl.handle.net/2237/000327269afc7217-ca7b-4c96-83ca-de13e1a02d01
名前 / ファイル | ライセンス | アクション |
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-10-14 | |||||
タイトル | ||||||
タイトル | Prospective evaluation of alternative donor from unrelated donor and cord blood in adult acute leukemia and myelodysplastic syndrome | |||||
言語 | en | |||||
著者 |
Terakura, Seitaro
× Terakura, Seitaro× Nishida, Tetsuya× Sawa, Masashi× Kato, Tomonori× Miyao, Kotaro× Ozawa, Yukiyasu× Goto, Tatsunori× Kohno, Akio× Ozeki, Kazutaka× Onishi, Yasushi× Fukuhara, Noriko× Fujii, Nobuharu× Yokoyama, Hisayuki× Kasai, Masanobu× Iida, Hiroatsu× Kanemura, Nobuhiro× Endo, Tomoyuki× Ago, Hiroatsu× Onizuka, Makoto× Iyama, Satoshi× Nawa, Yuichiro× Nakamae, Mika× Nagata, Yasuyuki× Kurahashi, Shingo× Tomiya, Yasuo× Yanagisawa, Atsumi× Suzuki, Ritsuro× Kuwatsuka, Yachiyo× Atsuta, Yoshiko× Miyamura, Koichi× Murata, Makoto |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Acute lymphocytic leukaemia | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Acute myeloid leukaemia | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Bone marrow transplantation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Medical research | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Myelodysplastic syndrome | |||||
抄録 | ||||||
内容記述 | A prospectively registered observational study was conducted to assess the significance of allogeneic hematopoietic stem cell transplantation from highly HLA-matched unrelated donors (UD) and cord blood (CB) on outcomes in adult acute leukemia (AL) and myelodysplastic syndrome (MDS). Between 2007 and 2015, 231 transplant-eligible patients were registered for a phase 2 study of alternative donor transplantation. After registration, a sufficient time period was given to find appropriate UD. Patients received CB transplantation (CBT) if an appropriate UD was unavailable. In total, 119 patients received CBT (106 AL and 13 MDS) and 91 patients received UD transplantation (UDT) (86 AL and 5 MDS). The median age was 39 years in both groups. The primary objective was overall survival (OS); secondary objectives included cumulative incidences of non-relapse mortality (NRM) and relapse, and disease-free survival. Diagnosis, disease status at transplantation, refined disease risk index, and hematopoietic cell transplant-specific comorbidity index did not differ between UDT and CBT. In multivariate analyses, graft source was not a significant risk factor for all objectives. In adjusted analyses, UDT and CBT showed similar OS, NRM, and relapse in this prospective study. CB can be a comparable alternative stem cell source to UD by achieving a timely transplant. | |||||
言語 | en | |||||
内容記述タイプ | Abstract | |||||
内容記述 | ||||||
内容記述 | ファイル公開:2021/01/01 | |||||
言語 | ja | |||||
内容記述タイプ | Other | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | nature | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプresource | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1038/s41409-020-0859-8 | |||||
ISSN(print) | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0268-3369 | |||||
書誌情報 |
en : Bone Marrow Transplantation 巻 55, 号 7, p. 1399-1409, 発行日 2020-07 |
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著者版フラグ | ||||||
値 | author |