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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Prospective evaluation of alternative donor from unrelated donor and cord blood in adult acute leukemia and myelodysplastic syndrome

http://hdl.handle.net/2237/00032726
http://hdl.handle.net/2237/00032726
9afc7217-ca7b-4c96-83ca-de13e1a02d01
名前 / ファイル ライセンス アクション
Manuscript_Terakura_et_al-2020-Bone_Marrow_Transplantation.pdf Manuscript_Terakura_et_al-2020-Bone_Marrow_Transplantation.pdf (298.0 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2020-10-14
タイトル
タイトル Prospective evaluation of alternative donor from unrelated donor and cord blood in adult acute leukemia and myelodysplastic syndrome
言語 en
著者 Terakura, Seitaro

× Terakura, Seitaro

WEKO 101655

en Terakura, Seitaro

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Nishida, Tetsuya

× Nishida, Tetsuya

WEKO 101656

en Nishida, Tetsuya

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Sawa, Masashi

× Sawa, Masashi

WEKO 101657

en Sawa, Masashi

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Kato, Tomonori

× Kato, Tomonori

WEKO 101658

en Kato, Tomonori

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Miyao, Kotaro

× Miyao, Kotaro

WEKO 101659

en Miyao, Kotaro

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Ozawa, Yukiyasu

× Ozawa, Yukiyasu

WEKO 101660

en Ozawa, Yukiyasu

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Goto, Tatsunori

× Goto, Tatsunori

WEKO 101661

en Goto, Tatsunori

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Kohno, Akio

× Kohno, Akio

WEKO 101662

en Kohno, Akio

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Ozeki, Kazutaka

× Ozeki, Kazutaka

WEKO 101663

en Ozeki, Kazutaka

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Onishi, Yasushi

× Onishi, Yasushi

WEKO 101664

en Onishi, Yasushi

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Fukuhara, Noriko

× Fukuhara, Noriko

WEKO 101665

en Fukuhara, Noriko

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Fujii, Nobuharu

× Fujii, Nobuharu

WEKO 101666

en Fujii, Nobuharu

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Yokoyama, Hisayuki

× Yokoyama, Hisayuki

WEKO 101667

en Yokoyama, Hisayuki

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Kasai, Masanobu

× Kasai, Masanobu

WEKO 101668

en Kasai, Masanobu

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Iida, Hiroatsu

× Iida, Hiroatsu

WEKO 101669

en Iida, Hiroatsu

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Kanemura, Nobuhiro

× Kanemura, Nobuhiro

WEKO 101670

en Kanemura, Nobuhiro

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Endo, Tomoyuki

× Endo, Tomoyuki

WEKO 101671

en Endo, Tomoyuki

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Ago, Hiroatsu

× Ago, Hiroatsu

WEKO 101672

en Ago, Hiroatsu

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Onizuka, Makoto

× Onizuka, Makoto

WEKO 101673

en Onizuka, Makoto

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Iyama, Satoshi

× Iyama, Satoshi

WEKO 101674

en Iyama, Satoshi

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Nawa, Yuichiro

× Nawa, Yuichiro

WEKO 101675

en Nawa, Yuichiro

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Nakamae, Mika

× Nakamae, Mika

WEKO 101676

en Nakamae, Mika

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Nagata, Yasuyuki

× Nagata, Yasuyuki

WEKO 101677

en Nagata, Yasuyuki

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Kurahashi, Shingo

× Kurahashi, Shingo

WEKO 101678

en Kurahashi, Shingo

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Tomiya, Yasuo

× Tomiya, Yasuo

WEKO 101679

en Tomiya, Yasuo

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Yanagisawa, Atsumi

× Yanagisawa, Atsumi

WEKO 101680

en Yanagisawa, Atsumi

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Suzuki, Ritsuro

× Suzuki, Ritsuro

WEKO 101681

en Suzuki, Ritsuro

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Kuwatsuka, Yachiyo

× Kuwatsuka, Yachiyo

WEKO 101682

en Kuwatsuka, Yachiyo

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Atsuta, Yoshiko

× Atsuta, Yoshiko

WEKO 101683

en Atsuta, Yoshiko

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Miyamura, Koichi

× Miyamura, Koichi

WEKO 101684

en Miyamura, Koichi

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Murata, Makoto

× Murata, Makoto

WEKO 101685

en Murata, Makoto

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
キーワード
主題Scheme Other
主題 Acute lymphocytic leukaemia
キーワード
主題Scheme Other
主題 Acute myeloid leukaemia
キーワード
主題Scheme Other
主題 Bone marrow transplantation
キーワード
主題Scheme Other
主題 Medical research
キーワード
主題Scheme Other
主題 Myelodysplastic syndrome
抄録
内容記述 A prospectively registered observational study was conducted to assess the significance of allogeneic hematopoietic stem cell transplantation from highly HLA-matched unrelated donors (UD) and cord blood (CB) on outcomes in adult acute leukemia (AL) and myelodysplastic syndrome (MDS). Between 2007 and 2015, 231 transplant-eligible patients were registered for a phase 2 study of alternative donor transplantation. After registration, a sufficient time period was given to find appropriate UD. Patients received CB transplantation (CBT) if an appropriate UD was unavailable. In total, 119 patients received CBT (106 AL and 13 MDS) and 91 patients received UD transplantation (UDT) (86 AL and 5 MDS). The median age was 39 years in both groups. The primary objective was overall survival (OS); secondary objectives included cumulative incidences of non-relapse mortality (NRM) and relapse, and disease-free survival. Diagnosis, disease status at transplantation, refined disease risk index, and hematopoietic cell transplant-specific comorbidity index did not differ between UDT and CBT. In multivariate analyses, graft source was not a significant risk factor for all objectives. In adjusted analyses, UDT and CBT showed similar OS, NRM, and relapse in this prospective study. CB can be a comparable alternative stem cell source to UD by achieving a timely transplant.
言語 en
内容記述タイプ Abstract
内容記述
内容記述 ファイル公開:2021/01/01
言語 ja
内容記述タイプ Other
出版者
言語 en
出版者 nature
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1038/s41409-020-0859-8
ISSN(print)
収録物識別子タイプ PISSN
収録物識別子 0268-3369
書誌情報 en : Bone Marrow Transplantation

巻 55, 号 7, p. 1399-1409, 発行日 2020-07
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