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Assessment of the association between the polymorphism rs1256031 of the estrogen receptor β gene and GDM susceptibility
https://doi.org/10.18999/nagjms.82.4.703
https://doi.org/10.18999/nagjms.82.4.7035b14f364-108a-4aed-bb03-40dacd247825
名前 / ファイル | ライセンス | アクション |
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11_Xi.pdf (222.4 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2020-11-26 | |||||
タイトル | ||||||
タイトル | Assessment of the association between the polymorphism rs1256031 of the estrogen receptor β gene and GDM susceptibility | |||||
言語 | en | |||||
著者 |
Li, Xi
× Li, Xi× Su, Jindi× Zheng, Kaifeng× Lin, Sheng× Chen, Shiguo× Wang, Baojiang× Lai, Liping× Duan, Shan |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
権利 | ||||||
言語 | en | |||||
権利情報Resource | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||
権利情報 | Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | gestational diabetes mellitus | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | estrogen receptor β | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | single nucleotide polymorphism | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Estrogen has an important role in regulating glucose homeostasis, and existing evidence indicates that it might be involved in the development of hyperglycemia in pregnancy. It mediates its effect through estrogen receptors including the nuclear receptor ERβ encoded by ESR2. The association between the ESR2 polymorphism rs1256031 and GDM susceptibility has not been investigated yet. This study aimed to evaluate the relationship between rs1256031 and GDM risk in Chinese population. A total of 241 GDM patients and 139 healthy pregnant women were recruited for this study. The rs1256031 genotype was examined by time-of-flight mass spectrometry and the association between rs1256031 and GDM susceptibility was assessed by binary logistic regression in three different genetic models. The polymorphism rs1256031 was not associated with GDM susceptibility in additive [OR (95% CI) = 0.871 (0.453,1.675); P = 0.680], dominant [OR (95% CI) = 0.908 (0.495,1.665); P = 0.755] or recessive [OR (95% CI) = 0.912 (0.591,1.408); P = 0.677] models after adjusting for confounding factors. We observed no association between the polymorphism rs1256031 in the ESR2 gene and GDM susceptibility in Chinese pregnant women. | |||||
言語 | en | |||||
出版者 | ||||||
出版者 | Nagoya University Graduate School of Medicine, School of Medicine | |||||
言語 | en | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
ID登録 | ||||||
ID登録 | 10.18999/nagjms.82.4.703 | |||||
ID登録タイプ | JaLC | |||||
関連情報 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | URI | |||||
関連識別子 | http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/824.html | |||||
ISSN(print) | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0027-7622 | |||||
ISSN(Online) | ||||||
収録物識別子タイプ | EISSN | |||||
収録物識別子 | 2186-3326 | |||||
書誌情報 |
en : Nagoya Journal of Medical Science 巻 82, 号 4, p. 703-709, 発行日 2020-11 |
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著者版フラグ | ||||||
値 | publisher |