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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 82(4)

Vascular events from carotid artery atherosclerosis after radiation therapy for laryngeal and hypopharyngeal cancer: the incidence and risk factors

https://doi.org/10.18999/nagjms.82.4.747
https://doi.org/10.18999/nagjms.82.4.747
ebdcb622-205b-469c-a921-8f8cbbadfc23
名前 / ファイル ライセンス アクション
15_Makita.pdf 15_Makita.pdf (5.5 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2020-11-26
タイトル
タイトル Vascular events from carotid artery atherosclerosis after radiation therapy for laryngeal and hypopharyngeal cancer: the incidence and risk factors
著者 Makita, Chiyoko

× Makita, Chiyoko

WEKO 102453

Makita, Chiyoko

Search repository
Okada, Sunaho

× Okada, Sunaho

WEKO 102454

Okada, Sunaho

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Kajiura, Yuichi

× Kajiura, Yuichi

WEKO 102455

Kajiura, Yuichi

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Tanaka, Osamu

× Tanaka, Osamu

WEKO 102456

Tanaka, Osamu

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Asahi, Yuki

× Asahi, Yuki

WEKO 102457

Asahi, Yuki

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Yamada, Nansei

× Yamada, Nansei

WEKO 102458

Yamada, Nansei

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Yanagida, Masami

× Yanagida, Masami

WEKO 102459

Yanagida, Masami

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Kumagai, Morio

× Kumagai, Morio

WEKO 102460

Kumagai, Morio

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Murase, Satoru

× Murase, Satoru

WEKO 102461

Murase, Satoru

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Ito, Masaya

× Ito, Masaya

WEKO 102462

Ito, Masaya

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Kumano, Tomoyasu

× Kumano, Tomoyasu

WEKO 102463

Kumano, Tomoyasu

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Matsuo, Masayuki

× Matsuo, Masayuki

WEKO 102464

Matsuo, Masayuki

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キーワード
主題Scheme Other
主題 Laryngeal and hypopharyngeal cancer
キーワード
主題Scheme Other
主題 Carotid artery atherosclerosis
キーワード
主題Scheme Other
主題 Transient ischemic attack
キーワード
主題Scheme Other
主題 Stroke
キーワード
主題Scheme Other
主題 Carotid artery stenting
抄録
内容記述 In this retrospective cohort study, we evaluated the incidence of vascular events from carotid artery atherosclerosis after radiotherapy indication for laryngeal and hypopharyngeal cancer. From January 2007 to December 2016, we investigated 111 laryngeal/hypopharyngeal cancer patients who underwent curative radiotherapy and were followed up for ≥1 year (median follow-up duration, 60 months). We evaluated the incidence of vascular events from carotid artery atherosclerosis, defined as a transient ischemic attack or an atherothrombotic cerebral infarction, or from undergoing treatment such as carotid artery stenting for carotid artery stenosis. The median radiation dose was 66 Gy (range, 60–74); 48 patients (43.2%) received concurrent chemotherapy. The 5-year overall survival was 86.2%. Six patients required treatment for carotid artery disease. Carotid stenting was performed in three patients with carotid artery stenosis; three patients developed atherosclerotic cerebral infarction and received medical treatment, with a median of 51.7 months (range, 0.3–78.3) after radiotherapy initiation. The vascular event occurrence rate was 5.4% within 5 years and 10.7% within 8 years. In the univariate analysis, dyslipidemia, diabetes mellitus, and carotid calcification were significant factors for event occurrence. Because three out of six cases occurred out of the irradiated field, no carotid artery or carotid bulb dosimetric parameters showed significant cor-relation. As laryngeal/hypopharyngeal cancer patients, particularly with complications including dyslipidemia and diabetes mellitus, are at a high risk of carotid artery stenosis after radiotherapy, long-term carotid artery evaluation is necessary. Early intervention by stroke specialists can reduce the risk of fatal cerebral infarction.
内容記述タイプ Abstract
出版者
出版者 Nagoya University Graduate School of Medicine, School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.82.4.747
ID登録タイプ JaLC
関連情報
関連タイプ isVersionOf
識別子タイプ URI
関連識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/824.html
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
ISSN(Online)
収録物識別子タイプ ISSN
収録物識別子 2186-3326
書誌情報 Nagoya Journal of Medical Science

巻 82, 号 4, p. 747-761, 発行日 2020-11
著者版フラグ
値 publisher
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