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  1. B200 工学部/工学研究科
  2. B200a 雑誌掲載論文
  3. 学術雑誌

Magnetic self-assembly of toroidal hepatic microstructures for micro-tissue fabrication

http://hdl.handle.net/2237/00033203
c31379c9-98de-4de8-ab0e-33fbf987c34a
名前 / ファイル ライセンス アクション
Revised_manuscript_M_Takeuchi.pdf Revised_manuscript_M_Takeuchi (3.8 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2020-12-15
タイトル
タイトル Magnetic self-assembly of toroidal hepatic microstructures for micro-tissue fabrication
著者 Takeuchi, Masaru

× Takeuchi, Masaru

WEKO 102571

Takeuchi, Masaru

Search repository
Iriguchi, Masaki

× Iriguchi, Masaki

WEKO 102572

Iriguchi, Masaki

Search repository
Hattori, Mamoru

× Hattori, Mamoru

WEKO 102573

Hattori, Mamoru

Search repository
Kim, Eunhye

× Kim, Eunhye

WEKO 102574

Kim, Eunhye

Search repository
Ichikawa, Akihiko

× Ichikawa, Akihiko

WEKO 102575

Ichikawa, Akihiko

Search repository
Hasegawa, Yasuhisa

× Hasegawa, Yasuhisa

WEKO 102576

Hasegawa, Yasuhisa

Search repository
Huang, Qiang

× Huang, Qiang

WEKO 102577

Huang, Qiang

Search repository
Fukuda, Toshio

× Fukuda, Toshio

WEKO 102578

Fukuda, Toshio

Search repository
権利
権利情報 This is the Accepted Manuscript version of an article accepted for publication in [Biomedical Materials].IOP Publishing Ltd is not responsible for any errors or omissions in this version of the manuscript or any version derived from it. The Version of Record is available online at [10.1088/1748-605X/ab8487]
権利
権利情報 This Accepted Manuscript is available for reuse under a CC BY-NC-ND licence after the 12 month embargo period provided that all the terms of the licence are adhered to”
キーワード
主題Scheme Other
主題 Magnetic self-assembly
キーワード
主題Scheme Other
主題 Microfabrication
キーワード
主題Scheme Other
主題 Micromanipulation
抄録
内容記述 In this study, we developed a procedure for assembling hepatic microstructures into tube shapes using magnetic self-assembly for in vitro 3D micro-tissue fabrication. To this end, biocompatible hydrogels, which have a toroidal shape, were made using the micro-patterned electrodeposition method. Ferrite particles were used to coat the fabricated toroidal hydrogel microcapsules using a poly-L-lysine membrane. The microcapsules were then magnetized with a 3 T magnetic field, and assembled using a magnetic self-assembly process. During electrodeposition, hepatic cells were trapped inside the microcapsules, and they were cultured to construct tissue-like structures. The magnetized toroidal microstructures then automatically assembled to form tube structures. Shaking was used to enhance the assembly process, and the shaking speed was experimentally optimized to achieve the high-speed assembly of longer tube structures. The flow velocity inside the dish during shaking was measured by particle image velocimetry. Hepatic functions were evaluated to check for side-effects of the magnetized ferrite particles on the microstructures. Collectively, our findings indicated that the developed method can achieve the high-speed assembly of a large number of microstructures to form tissue-like hepatic structures.
内容記述タイプ Abstract
出版者
出版者 IOP publishing
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1088/1748-605X/ab8487
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 1748-605X
書誌情報 Biomedical Materials

巻 15, 号 5, p. 055001, 発行日 2020-09
著者版フラグ
値 author
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