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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Role of carbonic anhydrases in ferroptosis-resistance

http://hdl.handle.net/2237/00033214
http://hdl.handle.net/2237/00033214
475e0f12-9d81-435e-a5d7-52bf407547ca
名前 / ファイル ライセンス アクション
ZL_CA9_review_ABB2020.pdf ZL_CA9_review_ABB2020 (1.9 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2020-12-17
タイトル
タイトル Role of carbonic anhydrases in ferroptosis-resistance
言語 en
著者 Li, Zan

× Li, Zan

WEKO 102619

en Li, Zan

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Jiang, Li

× Jiang, Li

WEKO 102620

en Jiang, Li

Search repository
Toyokuni, Shinya

× Toyokuni, Shinya

WEKO 102621

en Toyokuni, Shinya

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 © 2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
キーワード
主題Scheme Other
主題 Carbonic anhydrase
キーワード
主題Scheme Other
主題 Iron
キーワード
主題Scheme Other
主題 Ferroptosis
キーワード
主題Scheme Other
主題 Mesothelioma
抄録
内容記述 Iron is essential for all the lives on earth but may trigger a switch toward ferroptosis, a novel form of regulated necrosis. Carbonic anhydrases (CAs) are ubiquitous enzymes from microbes to humans. The primary function of CAs is to regulate cellular pH by hydrating carbon dioxide (CO2) to protons (H^+) and bicarbonate ions (HCO3^−). Furthermore, CAs play roles in biosynthetic reactions, such as gluconeogenesis, lipogenesis, ureagenesis and are also associated with tumor metabolism, suggesting that CAs may be a potential target for the treatment of cancers. We have recently revealed a novel function of CA IX in ferroptosis-resistance by using human malignant mesothelioma cells. Herein, we aim to review the potential molecular association between ferroptosis and CAs, from the viewpoint of iron-metabolism, lipogenesis and signaling pathways both under physiological and pathological contexts.
言語 en
内容記述タイプ Abstract
内容記述
内容記述 ファイル公開:2021-08-15
言語 ja
内容記述タイプ Other
出版者
言語 en
出版者 Elsevier
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1016/j.abb.2020.108440
ISSN(print)
収録物識別子タイプ PISSN
収録物識別子 0003-9861
書誌情報 en : Archives of Biochemistry and Biophysics

巻 689, p. 108440, 発行日 2020-08-15
著者版フラグ
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