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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

An Oncogenic Alteration Creates a Microenvironment that Promotes Tumor Progression by Conferring a Metabolic Advantage to Regulatory T Cells

http://hdl.handle.net/2237/00033248
faf51752-06fe-4f8a-b01b-c1b90ce1c8c4
名前 / ファイル ライセンス アクション
Kumagai_et_al_immunity_20200627-2.pdf Kumagai_et_al_immunity_20200627-2 (3.4 MB)
Kumagai_et_al_immunity_suppl_20200628.pdf Kumagai_et_al_immunity_suppl_20200628 (2.9 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2021-01-12
タイトル
タイトル An Oncogenic Alteration Creates a Microenvironment that Promotes Tumor Progression by Conferring a Metabolic Advantage to Regulatory T Cells
著者 Kumagai, Shogo

× Kumagai, Shogo

WEKO 102821

Kumagai, Shogo

Search repository
Togashi, Yosuke

× Togashi, Yosuke

WEKO 102822

Togashi, Yosuke

Search repository
Sakai, Chika

× Sakai, Chika

WEKO 102823

Sakai, Chika

Search repository
Kawazoe, Akihito

× Kawazoe, Akihito

WEKO 102824

Kawazoe, Akihito

Search repository
Kawazu, Masahito

× Kawazu, Masahito

WEKO 102825

Kawazu, Masahito

Search repository
Ueno, Toshihide

× Ueno, Toshihide

WEKO 102826

Ueno, Toshihide

Search repository
Sato, Eiichi

× Sato, Eiichi

WEKO 102827

Sato, Eiichi

Search repository
Kuwata, Takeshi

× Kuwata, Takeshi

WEKO 102828

Kuwata, Takeshi

Search repository
Kinoshita, Takahiro

× Kinoshita, Takahiro

WEKO 102829

Kinoshita, Takahiro

Search repository
Yamamoto, Masami

× Yamamoto, Masami

WEKO 102830

Yamamoto, Masami

Search repository
Nomura, Sachiyo

× Nomura, Sachiyo

WEKO 102831

Nomura, Sachiyo

Search repository
Tsukamoto, Tetsuya

× Tsukamoto, Tetsuya

WEKO 102832

Tsukamoto, Tetsuya

Search repository
Mano, Hiroyuki

× Mano, Hiroyuki

WEKO 102833

Mano, Hiroyuki

Search repository
Shitara, Kohei

× Shitara, Kohei

WEKO 102834

Shitara, Kohei

Search repository
Nishikawa, Hiroyoshi

× Nishikawa, Hiroyoshi

WEKO 102835

Nishikawa, Hiroyoshi

Search repository
権利
権利情報 © 2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
キーワード
主題Scheme Other
主題 gastric cancer
キーワード
主題Scheme Other
主題 RHOA mutation
キーワード
主題Scheme Other
主題 regulatory T cell
キーワード
主題Scheme Other
主題 fatty acid metabolism
キーワード
主題Scheme Other
主題 non-inflamed tumor
キーワード
主題Scheme Other
主題 PI3K inhibitor
抄録
内容記述 Only a small percentage of patients afflicted with gastric cancer (GC) respond to immune checkpoint blockade (ICB). To study the mechanisms underlying this resistance, we examined the immune landscape of GC. A subset of these tumors was characterized by high frequencies of regulatory T (Treg) cells and low numbers of effector T cells. Genomic analyses revealed that these tumors bore mutations in RHOA that are known to drive tumor progression. RHOA mutations in cancer cells activated the PI3K-AKT-mTOR signaling pathway, increasing production of free fatty acids that are more effectively consumed by Treg cells than effector T cells. RHOA mutant tumors were resistant to PD-1 blockade but responded to combination of PD-1 blockade with inhibitors of the PI3K pathway or therapies targeting Treg cells. We propose that the metabolic advantage conferred by RHOA mutations enables Treg cell accumulation within GC tumors, generating an immunosuppressive TME that underlies resistance to ICB.
内容記述タイプ Abstract
内容記述
内容記述 ファイル公開:2021-07-14
内容記述タイプ Other
出版者
出版者 Elsevier
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1016/j.immuni.2020.06.016
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 1074-7613
書誌情報 Immunity

巻 53, 号 1, p. 187-203.e8, 発行日 2020-07-14
著者版フラグ
値 author
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