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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Comprehensive Detection of Candidate Pathogens in the Lower Respiratory Tract of Pediatric Patients With Unexpected Cardiopulmonary Deterioration Using Next-Generation Sequencing

http://hdl.handle.net/2237/00033524
http://hdl.handle.net/2237/00033524
3a2a97cb-5333-41af-a48e-6ccf105462b0
名前 / ファイル ライセンス アクション
MS_Takeuchi.pdf MS_Takeuchi (420.9 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2021-02-12
タイトル
タイトル Comprehensive Detection of Candidate Pathogens in the Lower Respiratory Tract of Pediatric Patients With Unexpected Cardiopulmonary Deterioration Using Next-Generation Sequencing
言語 en
著者 Takeuchi, Suguru

× Takeuchi, Suguru

WEKO 103497

en Takeuchi, Suguru

Search repository
Kawada, Jun-ichi

× Kawada, Jun-ichi

WEKO 103498

en Kawada, Jun-ichi

Search repository
Horiba, Kazuhiro

× Horiba, Kazuhiro

WEKO 103499

en Horiba, Kazuhiro

Search repository
Yamaguchi, Makoto

× Yamaguchi, Makoto

WEKO 103500

en Yamaguchi, Makoto

Search repository
Okumura, Toshihiko

× Okumura, Toshihiko

WEKO 103501

en Okumura, Toshihiko

Search repository
Suzuki, Takako

× Suzuki, Takako

WEKO 103502

en Suzuki, Takako

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Torii, Yuka

× Torii, Yuka

WEKO 103503

en Torii, Yuka

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Kawabe, Shinji

× Kawabe, Shinji

WEKO 103504

en Kawabe, Shinji

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Wada, Sho

× Wada, Sho

WEKO 103505

en Wada, Sho

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Ikeyama, Takanari

× Ikeyama, Takanari

WEKO 103506

en Ikeyama, Takanari

Search repository
Ito, Yoshinori

× Ito, Yoshinori

WEKO 103507

en Ito, Yoshinori

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 This is a non-final version of an article published in final form in (Pediatric Critical Care Medicine. v.21, n.11, 2020, p.e1026-e1030).
キーワード
主題Scheme Other
主題 next-generation sequencing
キーワード
主題Scheme Other
主題 NGS
キーワード
主題Scheme Other
主題 unexpected cardiopulmonary deterioration
キーワード
主題Scheme Other
主題 cardiopulmonary arrest
キーワード
主題Scheme Other
主題 bronchoalveolar lavage fluid
キーワード
主題Scheme Other
主題 pathogen
抄録
内容記述 Objectives: Next-generation sequencing has been applied to the investigation of microorganisms in several clinical settings. We investigated the infectious etiologies in respiratory specimens from pediatric patients with unexpected cardiopulmonary deterioration using next-generation sequencing.Design: Retrospective, single-center, observational study. Setting: Tertiary care, a children’s hospital. Subjects: The study enrolled a total of 16 pediatric patients with unexpected cardiopulmonary deterioration who were admitted to the PICU. Ten bronchoalveolar lavage fluid and six transtracheal aspirate samples were analyzed. Interventions: None. Measurements and Main Results: RNA libraries were prepared from specimens and analyzed using next-generation sequencing. One or more bacterial/viral pathogens were detected in the bronchoalveolar lavage fluid or transtracheal aspirate specimens from 10 patients. Bacterial and viral coinfection was considered in four cases. Compared with the conventional culture and viral antigen test results, an additional six bacterial and four viral pathogens were identified by next-generation sequencing. Conversely, among 18 pathogens identified by the conventional methods, nine pathogens were detected by next-generation sequencing. Candidate pathogens (e.g., coxsackievirus A6 and Chlamydia trachomatis) were detected by next-generation sequencing in four of 10 patients in whom no causative pathogen had been identified by conventional methods. Conclusions: Our results suggest that viral and bacterial infections are common triggers in unexpected cardiopulmonary deterioration in pediatric patients. Next-generation sequencing has the potential to contribute to clarification of the etiology of pediatric critical illness.
言語 en
内容記述タイプ Abstract
出版者
言語 en
出版者 Wolters Kluwer Health
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1097/PCC.0000000000002558
ISSN(print)
収録物識別子タイプ PISSN
収録物識別子 1529-7535
書誌情報 en : Pediatric Critical Care Medicine

巻 21, 号 11, p. e1026-e1030, 発行日 2020-11
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