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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 62(3-4)

Effects of sodium hyaluronate on experimental osteoarthritis in rabbit knee joints

https://doi.org/10.18999/nagjms.62.3-4.115
https://doi.org/10.18999/nagjms.62.3-4.115
3c71c6e3-b93e-44f4-ab6d-fd87bfe05b2a
名前 / ファイル ライセンス アクション
nj6235.pdf nj6235.pdf (137.7 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2006-02-03
タイトル
タイトル Effects of sodium hyaluronate on experimental osteoarthritis in rabbit knee joints
著者 Han, Fei

× Han, Fei

WEKO 9948

Han, Fei

Search repository
Ishiguro, Naoki

× Ishiguro, Naoki

WEKO 9949

Ishiguro, Naoki

Search repository
Ito, Takayasu

× Ito, Takayasu

WEKO 9950

Ito, Takayasu

Search repository
Sakai, Tadahiro

× Sakai, Tadahiro

WEKO 9951

Sakai, Tadahiro

Search repository
Iwata, Hisashi

× Iwata, Hisashi

WEKO 9952

Iwata, Hisashi

Search repository
キーワード
主題Scheme Other
主題 anterior cruciate ligament (ACL)
キーワード
主題Scheme Other
主題 osteoarthritis
キーワード
主題Scheme Other
主題 matrix metalloproteinase (MMP)
キーワード
主題Scheme Other
主題 Tissue inhibitor of metalloproteinase (TIMP)
キーワード
主題Scheme Other
主題 proteoglycan
抄録
内容記述 The aim of this study was to examine the effects of intraarticular administration of hyaluronan (HA) on cartilage degradation. Using a partial menisectomy model of osteoarthritis (OA) in the rabbit knee, the authors investigated the catabolic and anabolic changes induced by intraarticular injection of HA. To analyze anabolic changes, the authors assessed cell proliferation by measuring [3H] thymidine uptake, and proteoglycan biosynthesis by noting [35S] sulfate incorporation. For catabolic changes, messenger ribonucleic acid (mRNA) expression of interstitial collagenase (MMP-1), stromelysin-1 (MMP-3), and tissue inhibitor of metalloproteinase-1 (TIMP-1) in cartilage and synovium were detected with reverse transcriptase polymerase chain reaction (RT-PCR). Of significance for blocking the development of early OA in chondrocytes was the finding that total proteoglycan synthesis in the HA treatment group was significantly higher than in the controls. At the mRNA level in cartilage and synovium, HA inhibited MMP-3 and TIMP-1 production in the same way in the HA treatment group, while not affecting MMP-1 production. Thus it can be concluded that HA affects cartilage catabolism and anabolism to prevent the progress of OA.
内容記述タイプ Abstract
出版者
出版者 Nagoya University School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.62.3-4.115
ID登録タイプ JaLC
書誌情報 Nagoya Journal of Medical Science

巻 62, 号 3-4, p. 115-126, 発行日 1999-11
フォーマット
application/pdf
著者版フラグ
値 publisher
URI
識別子 http://hdl.handle.net/2237/5343
識別子タイプ HDL
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