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Effects of sodium hyaluronate on experimental osteoarthritis in rabbit knee joints
https://doi.org/10.18999/nagjms.62.3-4.115
https://doi.org/10.18999/nagjms.62.3-4.1153c71c6e3-b93e-44f4-ab6d-fd87bfe05b2a
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
nj6235.pdf (137.7 kB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2006-02-03 | |||||
| タイトル | ||||||
| タイトル | Effects of sodium hyaluronate on experimental osteoarthritis in rabbit knee joints | |||||
| 言語 | en | |||||
| 著者 |
Han, Fei
× Han, Fei× Ishiguro, Naoki× Ito, Takayasu× Sakai, Tadahiro× Iwata, Hisashi |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | anterior cruciate ligament (ACL) | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | osteoarthritis | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | matrix metalloproteinase (MMP) | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Tissue inhibitor of metalloproteinase (TIMP) | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | proteoglycan | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The aim of this study was to examine the effects of intraarticular administration of hyaluronan (HA) on cartilage degradation. Using a partial menisectomy model of osteoarthritis (OA) in the rabbit knee, the authors investigated the catabolic and anabolic changes induced by intraarticular injection of HA. To analyze anabolic changes, the authors assessed cell proliferation by measuring [3H] thymidine uptake, and proteoglycan biosynthesis by noting [35S] sulfate incorporation. For catabolic changes, messenger ribonucleic acid (mRNA) expression of interstitial collagenase (MMP-1), stromelysin-1 (MMP-3), and tissue inhibitor of metalloproteinase-1 (TIMP-1) in cartilage and synovium were detected with reverse transcriptase polymerase chain reaction (RT-PCR). Of significance for blocking the development of early OA in chondrocytes was the finding that total proteoglycan synthesis in the HA treatment group was significantly higher than in the controls. At the mRNA level in cartilage and synovium, HA inhibited MMP-3 and TIMP-1 production in the same way in the HA treatment group, while not affecting MMP-1 production. Thus it can be concluded that HA affects cartilage catabolism and anabolism to prevent the progress of OA. | |||||
| 言語 | en | |||||
| 出版者 | ||||||
| 出版者 | Nagoya University School of Medicine | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| ID登録 | ||||||
| ID登録 | 10.18999/nagjms.62.3-4.115 | |||||
| ID登録タイプ | JaLC | |||||
| ISSN（print） | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0027-7622 | |||||
| ISSN（Online） | ||||||
| 収録物識別子タイプ | EISSN | |||||
| 収録物識別子 | 2186-3326 | |||||
| 書誌情報 |
en : Nagoya Journal of Medical Science 巻 62, 号 3-4, p. 115-126, 発行日 1999-11 |
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| フォーマット | ||||||
| 値 | application/pdf | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
| URI | ||||||
| 識別子 | http://hdl.handle.net/2237/5343 | |||||
| 識別子タイプ | HDL | |||||
