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These findings are suggestive of vascular injury.   METHODS   Eighty patients (4 male, 76 female) with fulfilling primary FM criteria (FM (+) patient group), 60 patients (3 male, 57 female) with chronic musculoskeletal complaints but without FM (FM (+) patient control group) and 40 healthy volunteers (1 male, 39 female) without musculoskeletal complaints (healthy control group) were enrolled in this cross-sectional study. The study was carried out in two steps. In the first step, the clinical findings, routine laboratory tests, autoantibodies and radiological findings were investigated. The second step were consisted of the laboratory investigations of thrombomodulin and fibronectin as the mediators indicating vascular injury and proinflammatory cytokines in FM patients with Raynaud\u0027s phenomenon and/or livedo reticularis and in control groups.   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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 63(3-4)

Evaluation of vascular injury with proinflammatory cytokines, thrombomodulin and fibronectin in patients with primary fibromyalgia

https://doi.org/10.18999/nagjms.63.3-4.115
https://doi.org/10.18999/nagjms.63.3-4.115
675d8476-33f6-4bd6-90b9-1d8d4d8629d5
名前 / ファイル ライセンス アクション
nj6334.pdf nj6334.pdf (91.2 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2006-02-03
タイトル
タイトル Evaluation of vascular injury with proinflammatory cytokines, thrombomodulin and fibronectin in patients with primary fibromyalgia
著者 Pay, Salih

× Pay, Salih

WEKO 10020

Pay, Salih

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Calguneri, Meral

× Calguneri, Meral

WEKO 10021

Calguneri, Meral

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Caliskaner, Zafer

× Caliskaner, Zafer

WEKO 10022

Caliskaner, Zafer

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Dinc, Ayhan

× Dinc, Ayhan

WEKO 10023

Dinc, Ayhan

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Apras, Sule

× Apras, Sule

WEKO 10024

Apras, Sule

Search repository
Ertenli, Ihsan

× Ertenli, Ihsan

WEKO 10025

Ertenli, Ihsan

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Kiraz, Sedat

× Kiraz, Sedat

WEKO 10026

Kiraz, Sedat

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Cobankara, Veli

× Cobankara, Veli

WEKO 10027

Cobankara, Veli

Search repository
キーワード
主題Scheme Other
主題 Fibromyalgia
キーワード
主題Scheme Other
主題 proinflammatory cytokines
キーワード
主題Scheme Other
主題 thrombomodulin
キーワード
主題Scheme Other
主題 fibronectin
抄録
内容記述 OBJECTIVE Cold intolerance, cold induced peripheral vasospasm, Raynaud's phenomenon, livedo reticularis and immunoglobulin deposition in the skin are often encountered clinical and laboratory findings in patients with primary fibromyalgia (FM). These findings are suggestive of vascular injury. METHODS Eighty patients (4 male, 76 female) with fulfilling primary FM criteria (FM (+) patient group), 60 patients (3 male, 57 female) with chronic musculoskeletal complaints but without FM (FM (+) patient control group) and 40 healthy volunteers (1 male, 39 female) without musculoskeletal complaints (healthy control group) were enrolled in this cross-sectional study. The study was carried out in two steps. In the first step, the clinical findings, routine laboratory tests, autoantibodies and radiological findings were investigated. The second step were consisted of the laboratory investigations of thrombomodulin and fibronectin as the mediators indicating vascular injury and proinflammatory cytokines in FM patients with Raynaud's phenomenon and/or livedo reticularis and in control groups. RESULTS There were no differences between study and control groups with regard to laboratory, radiological and immunological (ANA, AntidsDNA, ENA, anticardiolipin IgG and IgM) results. No statistically significant differences were found in the levels of proinflammatory cytokines between FM (+) patient group and control groups (p > 0.05). Thrombomodulin was also shown statistically insignificant difference between FM (+) patient group and control groups (p > 0.05). However, fibronectin, another mediator of vascular injury, was higher in FM (+) patient group and the differences between FM (+) patients and each control groups were statistically significant (p < 0.0001). CONCLUSION Our results were suggestive of the presence of a non-immunological vascular injury in FM patients with Raynaud's phenomenon and/or livedo reticularis.
内容記述タイプ Abstract
出版者
出版者 Nagoya University School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.63.3-4.115
ID登録タイプ JaLC
書誌情報 Nagoya Journal of Medical Science

巻 63, 号 3-4, p. 115-122, 発行日 2000-11
フォーマット
application/pdf
著者版フラグ
値 publisher
URI
識別子 http://hdl.handle.net/2237/5359
識別子タイプ HDL
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