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Combined effect of docetaxel and cisplatin for non-small cell lung cancer cell lines in vitro
https://doi.org/10.18999/nagjms.63.3-4.129
https://doi.org/10.18999/nagjms.63.3-4.129d1168e9b-1e87-4b57-87f2-c4bb55ddfe28
名前 / ファイル | ライセンス | アクション |
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nj6336.pdf (110.2 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2006-02-03 | |||||
タイトル | ||||||
タイトル | Combined effect of docetaxel and cisplatin for non-small cell lung cancer cell lines in vitro | |||||
言語 | en | |||||
著者 |
Wang, Hong
× Wang, Hong |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | docetaxel (DOC) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | cisplatin (CDDP) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | non-small-cell lung cancer (NSCLC) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | combination chemotherapy | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | isobologram | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | cell cycle | |||||
抄録 | ||||||
内容記述 | Docetaxel (DOC) plus cisplatin (CDDP) is a novel combination chemotherapy for the treatment of advanced non-small-cell lung cancer (NSCLC). We investigated the combined effect of DOC with CDDP in sequence and the reverse schedule for NSCLC cell lines EBC-1 (squamous cell carcinoma) and RERF-LCMS (adenocarcinoma) using an MTT assay and an improved isobologram method. The results showed that the combination of DOC and CDDP in human lung cancer cell lines was antagonistic. To investigate the possible mechanism of the antagonistic effect, we focused on the cell cycle perturbation and the inhibition of apoptosis fractions induced by chemotherapeutic agents. Pretreatment of CDDP significantly blocked the following DOC-induced apoptosis fraction. Therefore we consider that the suppression of apoptosis could be one of the mechanisms for antagonistic effects of combination chemotherapy of DOC and CDDP. | |||||
言語 | en | |||||
内容記述タイプ | Abstract | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | Nagoya University School of Medicine | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
ID登録 | ||||||
ID登録 | 10.18999/nagjms.63.3-4.129 | |||||
ID登録タイプ | JaLC | |||||
ISSN(print) | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0027-7622 | |||||
ISSN(Online) | ||||||
収録物識別子タイプ | EISSN | |||||
収録物識別子 | 2186-3326 | |||||
書誌情報 |
en : Nagoya Journal of Medical Science 巻 63, 号 3-4, p. 129-137, 発行日 2000-11 |
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フォーマット | ||||||
application/pdf | ||||||
著者版フラグ | ||||||
値 | publisher | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2237/5361 | |||||
識別子タイプ | HDL |