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Mechanism-based Therapy for Leukemia: A Lesson from Atra Therapy
https://doi.org/10.18999/nagjms.64.3-4.103
https://doi.org/10.18999/nagjms.64.3-4.103cf79a83f-ac0e-45be-96e6-8357ed67eb3b
名前 / ファイル | ライセンス | アクション |
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2006-02-08 | |||||
タイトル | ||||||
タイトル | Mechanism-based Therapy for Leukemia: A Lesson from Atra Therapy | |||||
著者 |
Naoe, Tomoki
× Naoe, Tomoki |
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抄録 | ||||||
内容記述 | In the past two decades, there has been a tremendous increase in our understanding of the molecular mechanism of human leukemias. Leukemias are now recognized as a deregulated state of cell proliferation, differentiation and apoptosis, which is induced by gene alterations, including chromosomal translocations. Many of the mechanisms are potentially exploited as new targets for drug development. All-trans retinoic acid therapy for acute promyelocytic leukemia, which was initially developed as a differentiation therapy in an experienced-based manner, is currently known to be the first successful oncoprotein-directed therapy. Basic and clinical research into ATRA-resistance provides new directions for acute myeloid leukemia therapy. Anti-leukemia therapy will continue to lead the field of chemotherapy in the coming decades. | |||||
内容記述タイプ | Abstract | |||||
出版者 | ||||||
出版者 | Nagoya University School of Medicine | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
ID登録 | ||||||
ID登録 | 10.18999/nagjms.64.3-4.103 | |||||
ID登録タイプ | JaLC | |||||
書誌情報 |
Nagoya Journal of Medical Science 巻 64, 号 3-4, p. 103-108, 発行日 2001-11 |
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フォーマット | ||||||
application/pdf | ||||||
著者版フラグ | ||||||
値 | publisher | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2237/5372 | |||||
識別子タイプ | HDL |