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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 64(3-4)

Mechanism-based Therapy for Leukemia: A Lesson from Atra Therapy

https://doi.org/10.18999/nagjms.64.3-4.103
https://doi.org/10.18999/nagjms.64.3-4.103
cf79a83f-ac0e-45be-96e6-8357ed67eb3b
名前 / ファイル ライセンス アクション
nj6433.pdf nj6433.pdf (27.1 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2006-02-08
タイトル
タイトル Mechanism-based Therapy for Leukemia: A Lesson from Atra Therapy
著者 Naoe, Tomoki

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Naoe, Tomoki

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抄録
内容記述 In the past two decades, there has been a tremendous increase in our understanding of the molecular mechanism of human leukemias. Leukemias are now recognized as a deregulated state of cell proliferation, differentiation and apoptosis, which is induced by gene alterations, including chromosomal translocations. Many of the mechanisms are potentially exploited as new targets for drug development. All-trans retinoic acid therapy for acute promyelocytic leukemia, which was initially developed as a differentiation therapy in an experienced-based manner, is currently known to be the first successful oncoprotein-directed therapy. Basic and clinical research into ATRA-resistance provides new directions for acute myeloid leukemia therapy. Anti-leukemia therapy will continue to lead the field of chemotherapy in the coming decades.
内容記述タイプ Abstract
出版者
出版者 Nagoya University School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.64.3-4.103
ID登録タイプ JaLC
書誌情報 Nagoya Journal of Medical Science

巻 64, 号 3-4, p. 103-108, 発行日 2001-11
フォーマット
application/pdf
著者版フラグ
値 publisher
URI
識別子 http://hdl.handle.net/2237/5372
識別子タイプ HDL
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