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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 66(3-4)

Persistent helicobactor pylori infection and genetic polymorphisms of the host

https://doi.org/10.18999/nagjms.66.3-4.103
https://doi.org/10.18999/nagjms.66.3-4.103
34187b78-99d9-492d-9575-f81bd54d8027
名前 / ファイル ライセンス アクション
nj6634.pdf nj6634.pdf (165.4 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2006-02-10
タイトル
タイトル Persistent helicobactor pylori infection and genetic polymorphisms of the host
著者 Hamajima, Nobuyuki

× Hamajima, Nobuyuki

WEKO 10137

Hamajima, Nobuyuki

Search repository
キーワード
主題Scheme Other
主題 Helicobacter pylori
キーワード
主題Scheme Other
主題 Polymorphisms
キーワード
主題Scheme Other
主題 Interleukins
キーワード
主題Scheme Other
主題 Odds ratio dilution
抄録
内容記述 Helicobacter pylori (HP) infection elevates the risk of gastric diseases including peptic ulcer and gastric cancer. The infection induces inflammatory cytokines, which could work both for and against lifetime infection in the human stomach. Genetic polymorphisms of the cytokines and other related ligands, receptors, and enzymes may influence persistent HP infection. This paper summarizes studies done on the associations between anti-HP antibody seropositivity and polymorphism genotypes. To date, the associations with the polymorphisms of fucosyl transferase 2 (FUT2 or secretor gene), FUT3 (Lewis gene), interleukin 1A (IL-1A), IL-1B, IL-1RN, IL-8, IL-10, myeloperoxidase (MPO), and tumor necrosis factor A (TNF-A) and TNF-B have been reported. Polymorphisms of other related genes, CD14, CXC chemokine receptor 2 (CXCR2), IL-1RI, nuclear factor KB2 (NF-KB2), and Toll-like receptor 4 (TLR4), have the potential to influence persistent infection. Unpublished results from our datasets are reported here for all these polymorphisms except TLR4. Gene-environment interactions between these genotypes and smoking are reviewed. An effect on OR due to the involvement of unexposed subjects is demonstrated to elucidate a disadvantage in the studies done in areas where the majority of the population is not exposed to HP.
内容記述タイプ Abstract
出版者
出版者 Nagoya University School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.66.3-4.103
ID登録タイプ JaLC
書誌情報 Nagoya Journal of Medical Science

巻 66, 号 3-4, p. 103-117, 発行日 2003-11
フォーマット
application/pdf
著者版フラグ
値 publisher
URI
識別子 http://hdl.handle.net/2237/5395
識別子タイプ HDL
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