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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 66(3-4)

Radiation therapy for metastatic brain tumors from lung cancer : a review to devise individualized treatment plans

https://doi.org/10.18999/nagjms.66.3-4.119
https://doi.org/10.18999/nagjms.66.3-4.119
0e962036-7015-4256-889a-70e03dec0eb3
名前 / ファイル ライセンス アクション
nj6635.pdf nj6635.pdf (68.2 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2006-02-10
タイトル
タイトル Radiation therapy for metastatic brain tumors from lung cancer : a review to devise individualized treatment plans
著者 Itoh, Yoshiyuki

× Itoh, Yoshiyuki

WEKO 10138

Itoh, Yoshiyuki

Search repository
Fuwa, Nobukazu

× Fuwa, Nobukazu

WEKO 10139

Fuwa, Nobukazu

Search repository
Morita, Kozo

× Morita, Kozo

WEKO 10140

Morita, Kozo

Search repository
キーワード
主題Scheme Other
主題 Metastatic brain tumor
キーワード
主題Scheme Other
主題 Lung cancer
キーワード
主題Scheme Other
主題 Radiation
キーワード
主題Scheme Other
主題 Prognostic factors
抄録
内容記述 We retrospectively analyzed patients with brain metastasis from lung cancer to evaluate treatment modalities for metastatic brain tumors and to devise criteria for individualized treatment plans. Between October, 1986 and December, 1994, 90 patients were selected for this study. The majority (67.8%) received wholebrain radiotherapy (WBRT) alone. WBRT following surgical removal was carried out on 14 patients (15.5%). The median dose of radiation therapy was 43.3 Gy for WBRT. The results were as follows: (1) PS (1 and 2 vs. 3 and 4), which showed a significant difference (p<0.0001) in survival by both univariate analysis and multivariate analysis, (2) brain metastasis alone or concurrent metastases to other sites (p=0.0001) by univariate analysis, (3) the primary lesion controlled or uncontrolled (p=0.0006) by univariate analysis, (4) solitary brain metastasis or multiple brain metastases (p=0.0145) by univariate analysis. Patients were classified into 3 groups, A (PS1, 2, the primary lesion controlled, no distant metastasis and solitary brain metastasis), B (others except for groups A and C), and C (PS 3,4) based on 4 significant factors. The 1-year survival rates and median survival times were, respectively 75% and 1,767 days in Group A, 40.6% and 313 days in Group B, and 7.8% and 121 days in Group C (p<0.0001). Although the possibility of individualized treatment was suggested, based on 4 factors associated with the patient’s condition and disease progression before treatment for brain metastasis, further evaluation by randomized clinical trials is needed.
内容記述タイプ Abstract
出版者
出版者 Nagoya University School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.66.3-4.119
ID登録タイプ JaLC
書誌情報 Nagoya Journal of Medical Science

巻 66, 号 3-4, p. 119-128, 発行日 2003-11
フォーマット
application/pdf
著者版フラグ
値 publisher
URI
識別子 http://hdl.handle.net/2237/5396
識別子タイプ HDL
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