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Prolonged cytostatic tumor dormancy induced by serial exchange of chemotherapy in colorectal carcinoma
https://doi.org/10.18999/nagjms.67.1-2.9
https://doi.org/10.18999/nagjms.67.1-2.9da124880-5e6c-4223-9ed0-fc96d2ef0c5f
名前 / ファイル | ライセンス | アクション |
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nj6712.pdf (97.9 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2006-02-10 | |||||
タイトル | ||||||
タイトル | Prolonged cytostatic tumor dormancy induced by serial exchange of chemotherapy in colorectal carcinoma | |||||
言語 | en | |||||
著者 |
Ito, Katsuki
× Ito, Katsuki× Hibi, Kenji× Kodera, Yasuhiro× Akiyama, Seiji |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | tumor dormancy | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | serial exchange | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | chemotherapy | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | CEA (carcinoembryonic antigen) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | colorectal carcinoma | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background: To improve quality of life cytostatic effect of serially changed chemotherapy was investigated. Materials and Methods: Nonrandomized controlled trial in 17 patients with diagnosis of metastasis or recurrence following primary colorectal carcinoma was conducted from 1996 through 2001. Patients underwent low-dose CDDP+5-FU monitoring continual CEA level. Whenever uninterrupted increase for minimally 3 times of CEA level was observed, the next chemotherapy was chosen from the following chemotherapy: l-Leucovorin+5-FU, low-dose CPT-11. RESULTS: Six were died of carcinoma. Median survival time from primary surgery and those from the day of diagnosis of metastasis were 48.6 and 23.3 months, respectively. Most of the patients experienced decrease in CEA level after continuous increase. No severe side effects were observed in them except one who died of hyperosmolar diabetic syndrome. CONCLUSIONS: Although the present trial should await further follow-up to confirm the clinical relevance of its modality, longer survival attained by the serially exchanged chemotherapy would implicate future chemotherapeutic strategy. | |||||
言語 | en | |||||
出版者 | ||||||
出版者 | Nagoya University School of Medicine | |||||
言語 | en | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
ID登録 | ||||||
ID登録 | 10.18999/nagjms.67.1-2.9 | |||||
ID登録タイプ | JaLC | |||||
ISSN(print) | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0027-7622 | |||||
ISSN(Online) | ||||||
収録物識別子タイプ | EISSN | |||||
収録物識別子 | 2186-3326 | |||||
書誌情報 |
en : Nagoya Journal of Medical Science 巻 67, 号 1-2, p. 9-15, 発行日 2004-05 |
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フォーマット | ||||||
値 | application/pdf | |||||
著者版フラグ | ||||||
値 | publisher | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2237/5399 | |||||
識別子タイプ | HDL |