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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 67(1-2)

Prolonged cytostatic tumor dormancy induced by serial exchange of chemotherapy in colorectal carcinoma

https://doi.org/10.18999/nagjms.67.1-2.9
https://doi.org/10.18999/nagjms.67.1-2.9
da124880-5e6c-4223-9ed0-fc96d2ef0c5f
名前 / ファイル ライセンス アクション
nj6712.pdf nj6712.pdf (97.9 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2006-02-10
タイトル
タイトル Prolonged cytostatic tumor dormancy induced by serial exchange of chemotherapy in colorectal carcinoma
著者 Ito, Katsuki

× Ito, Katsuki

WEKO 10152

Ito, Katsuki

Search repository
Hibi, Kenji

× Hibi, Kenji

WEKO 10153

Hibi, Kenji

Search repository
Kodera, Yasuhiro

× Kodera, Yasuhiro

WEKO 10154

Kodera, Yasuhiro

Search repository
Akiyama, Seiji

× Akiyama, Seiji

WEKO 10155

Akiyama, Seiji

Search repository
キーワード
主題Scheme Other
主題 tumor dormancy
キーワード
主題Scheme Other
主題 serial exchange
キーワード
主題Scheme Other
主題 chemotherapy
キーワード
主題Scheme Other
主題 CEA (carcinoembryonic antigen)
キーワード
主題Scheme Other
主題 colorectal carcinoma
抄録
内容記述 Background: To improve quality of life cytostatic effect of serially changed chemotherapy was investigated. Materials and Methods: Nonrandomized controlled trial in 17 patients with diagnosis of metastasis or recurrence following primary colorectal carcinoma was conducted from 1996 through 2001. Patients underwent low-dose CDDP+5-FU monitoring continual CEA level. Whenever uninterrupted increase for minimally 3 times of CEA level was observed, the next chemotherapy was chosen from the following chemotherapy: l-Leucovorin+5-FU, low-dose CPT-11. RESULTS: Six were died of carcinoma. Median survival time from primary surgery and those from the day of diagnosis of metastasis were 48.6 and 23.3 months, respectively. Most of the patients experienced decrease in CEA level after continuous increase. No severe side effects were observed in them except one who died of hyperosmolar diabetic syndrome. CONCLUSIONS: Although the present trial should await further follow-up to confirm the clinical relevance of its modality, longer survival attained by the serially exchanged chemotherapy would implicate future chemotherapeutic strategy.
内容記述タイプ Abstract
出版者
出版者 Nagoya University School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.67.1-2.9
ID登録タイプ JaLC
書誌情報 Nagoya Journal of Medical Science

巻 67, 号 1-2, p. 9-15, 発行日 2004-05
フォーマット
application/pdf
著者版フラグ
値 publisher
URI
識別子 http://hdl.handle.net/2237/5399
識別子タイプ HDL
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