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The midkine family in cancer, inflammation and neural development
https://doi.org/10.18999/nagjms.67.3-4.71
https://doi.org/10.18999/nagjms.67.3-4.713fb81f0a-8636-4f10-9c7a-d8299fd8017a
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
p71KADOMATSU.pdf (229.4 kB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2006-02-10 | |||||
| タイトル | ||||||
| タイトル | The midkine family in cancer, inflammation and neural development | |||||
| 言語 | en | |||||
| 著者 |
Kadomatsu, Kenji
× Kadomatsu, Kenji |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | growth factor | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | midkine | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | cancer | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | infl ammation | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | nervous system | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The midkine (MK) family consists of only two members, namely MK and pleiotrophin (PTN). MK and PTN share receptors and biophysical characteristics, such as a heparin-binding property. MK and PTN exert several biological activities, which include fi brinolytic, anti-apoptotic, mitogenic, transforming, angiogenic, and chemotactic ones. These activities suggest that these growth factors are involved in carcinogenesis. Indeed, strong expression of MK and PTN in human carcinomas, and the anti-tumor activity of antisense oligonucleotides for MK and ribozymes for PTN further support their importance in cancer. In addition, MK plays critical roles in the pathogeneses of various disorders involving infl ammation such as reperfusion- and cisplatin-induced renal dysfunction and vascular restenosis after angioplasty. MK antisense oligonucleotide ameliorates these disorders. Zebrafi sh and Xenopus MK can induce neural tissues. MK and PTN are localized in the radial glial processes of the embryonic brain, and are induced in reactive astrocytes by ischemic insults. I summarize here the biological signifi cance of the MK family in cancer, infl ammation and neural development. | |||||
| 言語 | en | |||||
| 出版者 | ||||||
| 出版者 | Nagoya University School of Medicine | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| ID登録 | ||||||
| ID登録 | 10.18999/nagjms.67.3-4.71 | |||||
| ID登録タイプ | JaLC | |||||
| ISSN（print） | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0027-7622 | |||||
| ISSN（Online） | ||||||
| 収録物識別子タイプ | EISSN | |||||
| 収録物識別子 | 2186-3326 | |||||
| 書誌情報 |
en : Nagoya Journal of Medical Science 巻 67, 号 3-4, p. 71-82, 発行日 2005-06 |
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| フォーマット | ||||||
| 値 | application/pdf | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
| URI | ||||||
| 識別子 | http://hdl.handle.net/2237/5407 | |||||
| 識別子タイプ | HDL | |||||
