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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 67(3-4)

Polymorphism of dihydropyrimidine dehydrogenase (DPYD) Cys29Arg and risk of six malignancies in Japanese

https://doi.org/10.18999/nagjms.67.3-4.117
https://doi.org/10.18999/nagjms.67.3-4.117
99fdbcee-ef7f-4e8a-ad24-5f90d4ea84d0
名前 / ファイル ライセンス アクション
p117TANAKA,HISHIDA.pdf p117TANAKA,HISHIDA.pdf (127.5 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2006-02-10
タイトル
タイトル Polymorphism of dihydropyrimidine dehydrogenase (DPYD) Cys29Arg and risk of six malignancies in Japanese
著者 Tanaka, Daisuke

× Tanaka, Daisuke

WEKO 10213

Tanaka, Daisuke

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Hishida, Asahi

× Hishida, Asahi

WEKO 10214

Hishida, Asahi

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Matsuo, Keitaro

× Matsuo, Keitaro

WEKO 10215

Matsuo, Keitaro

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Iwata, Hiroji

× Iwata, Hiroji

WEKO 10216

Iwata, Hiroji

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Shinoda, Masayuki

× Shinoda, Masayuki

WEKO 10217

Shinoda, Masayuki

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Yamamura, Yoshitaka

× Yamamura, Yoshitaka

WEKO 10218

Yamamura, Yoshitaka

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Kato, Tomoyuki

× Kato, Tomoyuki

WEKO 10219

Kato, Tomoyuki

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Hatooka, Shunzo

× Hatooka, Shunzo

WEKO 10220

Hatooka, Shunzo

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Mitsudomi, Tetsuya

× Mitsudomi, Tetsuya

WEKO 10221

Mitsudomi, Tetsuya

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Kagami, Yoshitoyo

× Kagami, Yoshitoyo

WEKO 10222

Kagami, Yoshitoyo

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Ogura, Michinori

× Ogura, Michinori

WEKO 10223

Ogura, Michinori

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Tajima, Kazuo

× Tajima, Kazuo

WEKO 10224

Tajima, Kazuo

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Suyama, Motokazu

× Suyama, Motokazu

WEKO 10225

Suyama, Motokazu

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Naito, Mariko

× Naito, Mariko

WEKO 10226

Naito, Mariko

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Yamamoto, Kazuhito

× Yamamoto, Kazuhito

WEKO 10227

Yamamoto, Kazuhito

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Tamakoshi, Akiko

× Tamakoshi, Akiko

WEKO 10228

Tamakoshi, Akiko

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Hamajima, Nobuyuki

× Hamajima, Nobuyuki

WEKO 10229

Hamajima, Nobuyuki

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キーワード
主題Scheme Other
主題 Dihydropyrimidine dehydrogenase
キーワード
主題Scheme Other
主題 Genetic polymorphism
キーワード
主題Scheme Other
主題 Cancer risk
抄録
内容記述 Dihydropyrimidine dehydrogenase (DPD) is the enzyme catalyzing the first step of pyrimidine metabolism. To date, genetic polymorphisms of pyrimidine-synthesizing enzymes have been reported to be associated with the risk of malignant lymphoma or colon cancer. Accordingly, there may be associations between dihydropyrimidine dehydrogenase (DPYD) polymorphism and the risk of malignancies. We conducted a prevalent case-control study to investigate the associations between a functional polymorphism of dihydropyrimidine dehydrogenase, DPYD T85C, and the risk of six malignancies. Controls were 445 Nagoya City inhabitants without a history of malignancy who had participated in a health check-up between August and September 2000. Case subjects were 901 patients with malignancies (99 esophageal, 131 gastric, 143 colon, 179 lung, 243 breast, and 106 malignant lymphomas) who had visited Aichi Cancer Center Hospital between March 1999 and December 2000. No DPYD CC individuals were found in either cases or controls. The frequency of DPYD TC genotype was 6.3% in control subjects and 5.9% in all case subjects (not signifi cant). In a subgroup analysis, the frequency of TC genotype was highest in patients with gastric cancer (9.1%), followed by those with lung cancer (8.3%), with the lowest frequency in those with malignant lymphoma (1.9%). The gender- and age- adjusted odds ratios and 95% confi dence intervals for the TC genotype of gastric cancer and malignant lymphoma were 1.52 (0.71–3.28) and 0.31 (0.71–1.34), respectively. Although prevalent cases were used, this study suggested that the infl uence of DPYD T85C posed only a limited risk for the six malignancies.
内容記述タイプ Abstract
出版者
出版者 Nagoya University School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.67.3-4.117
ID登録タイプ JaLC
書誌情報 Nagoya Journal of Medical Science

巻 67, 号 3-4, p. 117-124, 発行日 2005-06
フォーマット
application/pdf
著者版フラグ
値 publisher
URI
識別子 http://hdl.handle.net/2237/5412
識別子タイプ HDL
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