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Cellular and systemic defense system against age-promoting stimuli
https://doi.org/10.18999/nagjms.68.1-2.9
https://doi.org/10.18999/nagjms.68.1-2.9505e8eb4-de75-4b55-aa43-beb480a6fe87
名前 / ファイル | ライセンス | アクション |
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p009_018.pdf (318.4 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2006-02-28 | |||||
タイトル | ||||||
タイトル | Cellular and systemic defense system against age-promoting stimuli | |||||
言語 | en | |||||
著者 |
Isobe, Ken-ichi
× Isobe, Ken-ichi× Ito, Sachiko× Haneda, Masataka× Ishida, Yoshiyuki× 磯部, 健一× 石田, 佳幸 |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Aging | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Defense system | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Stress | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Macrophage | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Although much progress has been achieved in aging research using lower animals, especially yeast and C. elegans, aging in humans remains puzzling. Here I offer my hypothesis of host defense against age-promoting stimuli, which holds that the cell itself has a defense system and multi-organism, an even more sophisticated one against age-promoting stimuli. Here I review recent achievements in aging research and try to explain their fi ndings in the light of my hypothesis. Age-promoting stimuli, including reactive oxygen species, telomere shortening or external stimuli such as UV or radiation induce stress responses in cells. The cellular defense system operates to overcome stimuli or repair damaged cellular components. Stress-induced damaged cells or infectious stimuli activate systemic defense systems, especially the innate immune system. Macrophages in the innate immune system are especially active not only in clearing damaged cells and repairing damaged tissue, but unfortunately, also in inducing age-related diseases. | |||||
言語 | en | |||||
出版者 | ||||||
出版者 | Nagoya University School of Medicine | |||||
言語 | en | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
ID登録 | ||||||
ID登録 | 10.18999/nagjms.68.1-2.9 | |||||
ID登録タイプ | JaLC | |||||
ISSN(print) | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0027-7622 | |||||
ISSN(Online) | ||||||
収録物識別子タイプ | EISSN | |||||
収録物識別子 | 2186-3326 | |||||
書誌情報 |
en : Nagoya Journal of Medical Science 巻 68, 号 1-2, p. 9-18, 発行日 2006-01 |
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フォーマット | ||||||
値 | application/pdf | |||||
著者版フラグ | ||||||
値 | publisher | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2237/6128 | |||||
識別子タイプ | HDL |