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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 68(1-2)

Cellular and systemic defense system against age-promoting stimuli

https://doi.org/10.18999/nagjms.68.1-2.9
https://doi.org/10.18999/nagjms.68.1-2.9
505e8eb4-de75-4b55-aa43-beb480a6fe87
名前 / ファイル ライセンス アクション
p009_018.pdf p009_018.pdf (318.4 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2006-02-28
タイトル
タイトル Cellular and systemic defense system against age-promoting stimuli
著者 Isobe, Ken-ichi

× Isobe, Ken-ichi

WEKO 11552

Isobe, Ken-ichi

Search repository
Ito, Sachiko

× Ito, Sachiko

WEKO 11553

Ito, Sachiko

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Haneda, Masataka

× Haneda, Masataka

WEKO 11554

Haneda, Masataka

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Ishida, Yoshiyuki

× Ishida, Yoshiyuki

WEKO 11555

Ishida, Yoshiyuki

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磯部, 健一

× 磯部, 健一

WEKO 11556

磯部, 健一

Search repository
石田, 佳幸

× 石田, 佳幸

WEKO 11557

石田, 佳幸

Search repository
キーワード
主題Scheme Other
主題 Aging
キーワード
主題Scheme Other
主題 Defense system
キーワード
主題Scheme Other
主題 Stress
キーワード
主題Scheme Other
主題 Macrophage
抄録
内容記述 Although much progress has been achieved in aging research using lower animals, especially yeast and C. elegans, aging in humans remains puzzling. Here I offer my hypothesis of host defense against age-promoting stimuli, which holds that the cell itself has a defense system and multi-organism, an even more sophisticated one against age-promoting stimuli. Here I review recent achievements in aging research and try to explain their fi ndings in the light of my hypothesis. Age-promoting stimuli, including reactive oxygen species, telomere shortening or external stimuli such as UV or radiation induce stress responses in cells. The cellular defense system operates to overcome stimuli or repair damaged cellular components. Stress-induced damaged cells or infectious stimuli activate systemic defense systems, especially the innate immune system. Macrophages in the innate immune system are especially active not only in clearing damaged cells and repairing damaged tissue, but unfortunately, also in inducing age-related diseases.
内容記述タイプ Abstract
出版者
出版者 Nagoya University School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.68.1-2.9
ID登録タイプ JaLC
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 00277622
書誌情報 Nagoya Journal of Medical Science

巻 68, 号 1-2, p. 9-18, 発行日 2006-01
フォーマット
application/pdf
著者版フラグ
値 publisher
URI
識別子 http://hdl.handle.net/2237/6128
識別子タイプ HDL
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