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  1. B100 理学部/理学研究科
  2. B100a 雑誌掲載論文
  3. 学術雑誌

A Drosophila Winged-helix nude (Whn)-like transcription factor with essential functions throughout development

http://hdl.handle.net/2237/7296
6310e6e8-7882-403a-a8f6-7263a6caaa16
名前 / ファイル ライセンス アクション
Dwhn_final_DGD.pdf Dwhn_final_DGD.pdf (2.0 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2007-02-09
タイトル
タイトル A Drosophila Winged-helix nude (Whn)-like transcription factor with essential functions throughout development
著者 Sugimura, Isamu

× Sugimura, Isamu

WEKO 15130

Sugimura, Isamu

Search repository
Adachi-Yamada, Takashi

× Adachi-Yamada, Takashi

WEKO 15131

Adachi-Yamada, Takashi

Search repository
Nishi, Yoshimi

× Nishi, Yoshimi

WEKO 15132

Nishi, Yoshimi

Search repository
Nishida, Yasuyoshi

× Nishida, Yasuyoshi

WEKO 15133

Nishida, Yasuyoshi

Search repository
権利
権利情報 The definitive version is available at www.blackwell-synergy.com
キーワード
主題Scheme Other
主題 Forkhead
キーワード
主題Scheme Other
主題 HNF-3
キーワード
主題Scheme Other
主題 development
キーワード
主題Scheme Other
主題 nude gene
キーワード
主題Scheme Other
主題 CNS
キーワード
主題Scheme Other
主題 PNS
キーワード
主題Scheme Other
主題 compound eye
キーワード
主題Scheme Other
主題 dorsal closure
抄録
内容記述 A Drosophila gene, Dwhn, encoding a putative transcriptional regulator with a DNA binding domain similar to that of mouse Winged‐helix nude (Whn) was cloned. Analyses of the phenotypes produced by a hypomorphic mutation and transgene expression suggested a role in cell fate decision during the differentiation of the compound eye, wing veins and bristles. During embryonic development, Dwhn expression started ubiquitously followed by more restricted expression in striking contrast to the expression patterns of other Drosophila forkhead (fkh) family genes whose local expression correlate well to their roles as local homeotic genes. This broad expression may correspond to the multiple defects in embryos homozygous for strong alleles, such as the defects in the formation of central and peripheral nervous systems, germ band retraction, head involution, and dorsal closure. The DNA binding specificity of Dwhn differed from that of Whn despite the strong sequence conservation in the DNA binding domain. Dwhn is the first invertebrate Whn‐like transcriptional regulator, and should provide insights into the basic functions and evolution of the whn family genes.
内容記述タイプ Abstract
出版者
出版者 Blackwell Synergy
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
DOI
関連識別子
識別子タイプ DOI
関連識別子 http://dx.doi.org/10.1046/j.1440-169x.2000.00509.x
ISSN
収録物識別子タイプ ISSN
収録物識別子 0012-1592
書誌情報 Development, Growth & Differentiation

巻 42, 号 3, p. 237-248, 発行日 2000-06
フォーマット
application/pdf
著者版フラグ
値 publisher
URI
識別子 http://hdl.handle.net/2237/7296
識別子タイプ HDL
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