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A Drosophila Winged-helix nude (Whn)-like transcription factor with essential functions throughout development
http://hdl.handle.net/2237/7296
http://hdl.handle.net/2237/72966310e6e8-7882-403a-a8f6-7263a6caaa16
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Dwhn_final_DGD.pdf (2.0 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2007-02-09 | |||||
| タイトル | ||||||
| タイトル | A Drosophila Winged-helix nude (Whn)-like transcription factor with essential functions throughout development | |||||
| 言語 | en | |||||
| 著者 |
Sugimura, Isamu
× Sugimura, Isamu× Adachi-Yamada, Takashi× Nishi, Yoshimi× Nishida, Yasuyoshi |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 権利 | ||||||
| 言語 | en | |||||
| 権利情報 | The definitive version is available at www.blackwell-synergy.com | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Forkhead | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | HNF-3 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | development | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | nude gene | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | CNS | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | PNS | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | compound eye | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | dorsal closure | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | A Drosophila gene, Dwhn, encoding a putative transcriptional regulator with a DNA binding domain similar to that of mouse Winged‐helix nude (Whn) was cloned. Analyses of the phenotypes produced by a hypomorphic mutation and transgene expression suggested a role in cell fate decision during the differentiation of the compound eye, wing veins and bristles. During embryonic development, Dwhn expression started ubiquitously followed by more restricted expression in striking contrast to the expression patterns of other Drosophila forkhead (fkh) family genes whose local expression correlate well to their roles as local homeotic genes. This broad expression may correspond to the multiple defects in embryos homozygous for strong alleles, such as the defects in the formation of central and peripheral nervous systems, germ band retraction, head involution, and dorsal closure. The DNA binding specificity of Dwhn differed from that of Whn despite the strong sequence conservation in the DNA binding domain. Dwhn is the first invertebrate Whn‐like transcriptional regulator, and should provide insights into the basic functions and evolution of the whn family genes. | |||||
| 言語 | en | |||||
| 出版者 | ||||||
| 出版者 | Blackwell Synergy | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1046/j.1440-169x.2000.00509.x | |||||
| ISSN | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0012-1592 | |||||
| 書誌情報 |
en : Development, Growth & Differentiation 巻 42, 号 3, p. 237-248, 発行日 2000-06 |
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| フォーマット | ||||||
| 値 | application/pdf | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
| URI | ||||||
| 識別子 | http://hdl.handle.net/2237/7296 | |||||
| 識別子タイプ | HDL | |||||
