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In vitro organogenesis of gut-like structures from mouse embryonic stem cells
http://hdl.handle.net/2237/7446
http://hdl.handle.net/2237/74463402b24e-52e8-4bb3-85fa-cfd221975244
名前 / ファイル | ライセンス | アクション |
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2007-03-08 | |||||
タイトル | ||||||
タイトル | In vitro organogenesis of gut-like structures from mouse embryonic stem cells | |||||
言語 | en | |||||
著者 |
Kuwahara, M.
× Kuwahara, M.× Ogaeri, T.× Matsuura, R.× Kogo, H.× Fujimoto, T.× Torihashi, S.× 鳥橋, 茂子 |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
権利 | ||||||
言語 | en | |||||
権利情報 | The definitive version is available at www.blackwell-synergy.com | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | c-kit | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | development | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | enteric neuron | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | gut | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | interstitial cells of Cajal | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | spontaneous contraction | |||||
抄録 | ||||||
内容記述 | Embryonic stem (ES) cells have pluripotency and give rise to many cell types and tissues including representatives of all three germ layers in the embryo. We previously reported that mouse ES cells formed contracting gut-like organs from embryoid bodies (EBs) (Stem Cells 20:41-49, 2002). These gut-like structures contracted spontaneously, and had large lumens surrounded by three layers, i.e., epithelium, lamina propria and muscularis. Ganglia were scattered along the periphery, and interstitial cells of Cajal (ICC) were distributed among the smooth muscle cells. In the present study, to determine whether they can be a model of gut organogenesis, we investigated the formation process of the gut-like structures in comparison with embryonic gut development. As a result, we found that the fundamental process of formation in vitro was similar to embryonic gut development in vivo. The result indicates that the gut-like structure is a useful tool not only for developmental study to determine the factors that induce gut organogenesis, but also for studies of enteric neuron and ICC development. | |||||
言語 | en | |||||
内容記述タイプ | Abstract | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | Blackwell | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプresource | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1111/j.1743-3150.2004.00468.x | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 1350-1925 | |||||
書誌情報 |
en : Neurogastroenterology & Motility 巻 16, 号 Suppl1, p. 14-18, 発行日 2004-04 |
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フォーマット | ||||||
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フォーマット | ||||||
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application/pdf | ||||||
著者版フラグ | ||||||
値 | publisher | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2237/7446 | |||||
識別子タイプ | HDL |