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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

In vitro organogenesis of gut-like structures from mouse embryonic stem cells

http://hdl.handle.net/2237/7446
http://hdl.handle.net/2237/7446
3402b24e-52e8-4bb3-85fa-cfd221975244
名前 / ファイル ライセンス アクション
fig3.jpg fig3.jpg (42.4 kB)
fig2.jpg fig2.jpg (44.2 kB)
fig1.jpg fig1.jpg (41.3 kB)
revised_version.pdf revised_version.pdf (115.3 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2007-03-08
タイトル
タイトル In vitro organogenesis of gut-like structures from mouse embryonic stem cells
言語 en
著者 Kuwahara, M.

× Kuwahara, M.

WEKO 15481

en Kuwahara, M.

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Ogaeri, T.

× Ogaeri, T.

WEKO 15482

en Ogaeri, T.

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Matsuura, R.

× Matsuura, R.

WEKO 15483

en Matsuura, R.

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Kogo, H.

× Kogo, H.

WEKO 15484

en Kogo, H.

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Fujimoto, T.

× Fujimoto, T.

WEKO 15485

en Fujimoto, T.

Search repository
Torihashi, S.

× Torihashi, S.

WEKO 15486

en Torihashi, S.

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鳥橋, 茂子

× 鳥橋, 茂子

WEKO 15487

ja 鳥橋, 茂子

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 The definitive version is available at www.blackwell-synergy.com
キーワード
主題Scheme Other
主題 c-kit
キーワード
主題Scheme Other
主題 development
キーワード
主題Scheme Other
主題 enteric neuron
キーワード
主題Scheme Other
主題 gut
キーワード
主題Scheme Other
主題 interstitial cells of Cajal
キーワード
主題Scheme Other
主題 spontaneous contraction
抄録
内容記述 Embryonic stem (ES) cells have pluripotency and give rise to many cell types and tissues including representatives of all three germ layers in the embryo. We previously reported that mouse ES cells formed contracting gut-like organs from embryoid bodies (EBs) (Stem Cells 20:41-49, 2002). These gut-like structures contracted spontaneously, and had large lumens surrounded by three layers, i.e., epithelium, lamina propria and muscularis. Ganglia were scattered along the periphery, and interstitial cells of Cajal (ICC) were distributed among the smooth muscle cells. In the present study, to determine whether they can be a model of gut organogenesis, we investigated the formation process of the gut-like structures in comparison with embryonic gut development. As a result, we found that the fundamental process of formation in vitro was similar to embryonic gut development in vivo. The result indicates that the gut-like structure is a useful tool not only for developmental study to determine the factors that induce gut organogenesis, but also for studies of enteric neuron and ICC development.
言語 en
内容記述タイプ Abstract
出版者
言語 en
出版者 Blackwell
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1111/j.1743-3150.2004.00468.x
ISSN
収録物識別子タイプ PISSN
収録物識別子 1350-1925
書誌情報 en : Neurogastroenterology & Motility

巻 16, 号 Suppl1, p. 14-18, 発行日 2004-04
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著者版フラグ
値 publisher
URI
識別子 http://hdl.handle.net/2237/7446
識別子タイプ HDL
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