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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Resident macrophages activated by lipopolysaccharide (LPS) suppress muscle tension and initiate inflammatory response in the gastrointestinal muscle layer

http://hdl.handle.net/2237/7448
http://hdl.handle.net/2237/7448
c324a87f-7feb-4c8f-b677-5ca0266b9085
名前 / ファイル ライセンス アクション
LPS-NOS_submit_doc.pdf LPS-NOS_submit_doc.pdf (80.2 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2007-03-08
タイトル
タイトル Resident macrophages activated by lipopolysaccharide (LPS) suppress muscle tension and initiate inflammatory response in the gastrointestinal muscle layer
言語 en
著者 Torihashi, Shigeko

× Torihashi, Shigeko

WEKO 15493

en Torihashi, Shigeko

Search repository
Ozaki, Hiroshi

× Ozaki, Hiroshi

WEKO 15494

en Ozaki, Hiroshi

Search repository
Hori, Masatoshi

× Hori, Masatoshi

WEKO 15495

en Hori, Masatoshi

Search repository
Kita, Muneto

× Kita, Muneto

WEKO 15496

en Kita, Muneto

Search repository
Ohota, Sachiyo

× Ohota, Sachiyo

WEKO 15497

en Ohota, Sachiyo

Search repository
Karaki, Hideaki

× Karaki, Hideaki

WEKO 15498

en Karaki, Hideaki

Search repository
鳥橋, 茂子

× 鳥橋, 茂子

WEKO 15499

ja 鳥橋, 茂子

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 The original publication is available at www.springerlink.com.
キーワード
主題Scheme Other
主題 macrophage
キーワード
主題Scheme Other
主題 gastrointestinal motility
キーワード
主題Scheme Other
主題 iNOS
キーワード
主題Scheme Other
主題 immune responses
キーワード
主題Scheme Other
主題 smooth muscle
抄録
内容記述 A great number of macrophages is found to be evenly distributed in the muscle layer of the gastrointestinal tract. We investigated their effects on smooth muscle contraction and the initiation of immune reactions such as inflammatory responses. Macrophages were demonstrated by uptake of FITC-dextran and their ultrastructural features were elucidated by electronmicroscopy. Muscle layers of rats’ ileums were incubated with lipopolysaccharide (LPS) for 4 to 8 h and the force of smooth muscle contraction was measured. The induction effect of inducible nitric oxide synthase on macrophages was then checked by immunohistochemistry. The expression of Main Histocompatible Complex (MHC) class II was also examined. Macrophages in the muscle layer were confirmed as resident macrophages and were different from a population of dendritic cells. After incubation with LPS, macrophages begun to express iNOS and produced NO, and it reduced smooth muscle contraction. iNOS immunopositive cells increased in a time dependent manner. Macrophages also began to express MHC class II. The total number of macrophages did not alter after incubation. Results indicate that resident macrophages in the muscle layer induced iNOS as an inflammatory reaction,affected smooth muscle contraction, and initiated immune response in the smooth muscle layer of the gastrointestinal tract, when activated by LPS.
言語 en
内容記述タイプ Abstract
出版者
言語 en
出版者 Springer
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1007/s004180050009
ISSN
収録物識別子タイプ PISSN
収録物識別子 0948-6143
書誌情報 en : Histochemistry & Cell Biology

巻 113, 号 2, p. 73-80, 発行日 2000-02
フォーマット
application/pdf
著者版フラグ
値 publisher
URI
識別子 http://hdl.handle.net/2237/7448
識別子タイプ HDL
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