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Macrophages in Muscle Layer of Gastrointestinal Tract : Impairment of Muscle Contraction by Treatment with Lipopolysaccharide
http://hdl.handle.net/2237/7457
http://hdl.handle.net/2237/74573f18b94c-7360-4d34-af6d-1c8d11dd2002
名前 / ファイル | ライセンス | アクション |
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acta_his_cyt_34_219.pdf (151.4 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2007-03-12 | |||||
タイトル | ||||||
タイトル | Macrophages in Muscle Layer of Gastrointestinal Tract : Impairment of Muscle Contraction by Treatment with Lipopolysaccharide | |||||
言語 | en | |||||
著者 |
Torihashi, Shigeko
× Torihashi, Shigeko× 鳥橋, 茂子 |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
権利 | ||||||
言語 | en | |||||
権利情報 | Copyright (c) 2001 By the Japan Society of Histochemistry and Cytochemistry | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Macrophage | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Gastrointestinal tract | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Smooth muscle | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Inducible nitric oxide synthase | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cyclooxygenase-2 | |||||
抄録 | ||||||
内容記述 | The morphology and function of resident macrophages in the muscle layer and in the subserosa of the gastrointestinal tract are described. FITC-dextran injected via the tail vein of a mouse or rat demonstrated a regular arrangement of macrophages on a whole mount preparation of the muscle layer. Electron microscopy revealed inactive phagocytosis under normal conditions. After a 4-8 hr incubation of rat ileal muscle with lipopolysaccharide (LPS) to investigate its effect on muscle contraction, macrophages began to express inducible nitric oxide synthase (iNOS) and released nitric oxide. This macrophage response was accompanied by the expression of cyclooxygenase-2 (COX-2) immunoreactivity and the production of prostaglandins. The muscarinic agonist-induced contraction was greatly inhibited by LPS treatment, and this inhibition was reversed by either iNOS or COX-2 inhibitors. We concluded that one of the functions of muscular macrophages was the modulation of smooth muscle contraction under pathological conditions. The mechanism of iNOS upregulation indicated by our experiment is discussed. | |||||
言語 | en | |||||
内容記述タイプ | Abstract | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | Japan Society of Histochemistry and Cytochemistry | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプresource | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1267/ahc.34.219 | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0044-5991 | |||||
書誌情報 |
en : Acta Histochem. Cytochem 巻 34, 号 4, p. 219-222, 発行日 2001 |
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フォーマット | ||||||
application/pdf | ||||||
著者版フラグ | ||||||
値 | publisher | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2237/7457 | |||||
識別子タイプ | HDL |