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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Macrophages in Muscle Layer of Gastrointestinal Tract : Impairment of Muscle Contraction by Treatment with Lipopolysaccharide

http://hdl.handle.net/2237/7457
http://hdl.handle.net/2237/7457
3f18b94c-7360-4d34-af6d-1c8d11dd2002
名前 / ファイル ライセンス アクション
acta_his_cyt_34_219.pdf acta_his_cyt_34_219.pdf (151.4 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2007-03-12
タイトル
タイトル Macrophages in Muscle Layer of Gastrointestinal Tract : Impairment of Muscle Contraction by Treatment with Lipopolysaccharide
言語 en
著者 Torihashi, Shigeko

× Torihashi, Shigeko

WEKO 15516

en Torihashi, Shigeko

Search repository
鳥橋, 茂子

× 鳥橋, 茂子

WEKO 15517

ja 鳥橋, 茂子

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 Copyright (c) 2001 By the Japan Society of Histochemistry and Cytochemistry
キーワード
主題Scheme Other
主題 Macrophage
キーワード
主題Scheme Other
主題 Gastrointestinal tract
キーワード
主題Scheme Other
主題 Smooth muscle
キーワード
主題Scheme Other
主題 Inducible nitric oxide synthase
キーワード
主題Scheme Other
主題 Cyclooxygenase-2
抄録
内容記述 The morphology and function of resident macrophages in the muscle layer and in the subserosa of the gastrointestinal tract are described. FITC-dextran injected via the tail vein of a mouse or rat demonstrated a regular arrangement of macrophages on a whole mount preparation of the muscle layer. Electron microscopy revealed inactive phagocytosis under normal conditions. After a 4-8 hr incubation of rat ileal muscle with lipopolysaccharide (LPS) to investigate its effect on muscle contraction, macrophages began to express inducible nitric oxide synthase (iNOS) and released nitric oxide. This macrophage response was accompanied by the expression of cyclooxygenase-2 (COX-2) immunoreactivity and the production of prostaglandins. The muscarinic agonist-induced contraction was greatly inhibited by LPS treatment, and this inhibition was reversed by either iNOS or COX-2 inhibitors. We concluded that one of the functions of muscular macrophages was the modulation of smooth muscle contraction under pathological conditions. The mechanism of iNOS upregulation indicated by our experiment is discussed.
言語 en
内容記述タイプ Abstract
出版者
言語 en
出版者 Japan Society of Histochemistry and Cytochemistry
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1267/ahc.34.219
ISSN
収録物識別子タイプ PISSN
収録物識別子 0044-5991
書誌情報 en : Acta Histochem. Cytochem

巻 34, 号 4, p. 219-222, 発行日 2001
フォーマット
application/pdf
著者版フラグ
値 publisher
URI
識別子 http://hdl.handle.net/2237/7457
識別子タイプ HDL
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