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  1. F100 環境医学研究所
  2. F100b 紀要
  3. Environmental medicine : annual report of the Research Institute of Environmental Medicine
  4. 47

Tail-suspension Induces Altered Expression of GAPDH and ZAKI-4β mRNAs in Rat Hindlimbs : Implication for Disuse Muscle Atrophy

https://doi.org/10.18999/envm.47.15
https://doi.org/10.18999/envm.47.15
4250861d-6929-404c-b91d-0e36a0f14792
名前 / ファイル ライセンス アクション
15-19.pdf 15-19.pdf (720.5 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2007-04-05
タイトル
タイトル Tail-suspension Induces Altered Expression of GAPDH and ZAKI-4β mRNAs in Rat Hindlimbs : Implication for Disuse Muscle Atrophy
言語 en
著者 Ohmori, Sachiko

× Ohmori, Sachiko

WEKO 15817

en Ohmori, Sachiko

Search repository
Kanda, Kazumi

× Kanda, Kazumi

WEKO 15818

en Kanda, Kazumi

Search repository
Mitsuyama, Hirohito

× Mitsuyama, Hirohito

WEKO 15819

en Mitsuyama, Hirohito

Search repository
Miyazaki, Takashi

× Miyazaki, Takashi

WEKO 15820

en Miyazaki, Takashi

Search repository
Cao, Xia

× Cao, Xia

WEKO 15821

en Cao, Xia

Search repository
Kambe, Fukushi

× Kambe, Fukushi

WEKO 15822

en Kambe, Fukushi

Search repository
Seo, Hisao

× Seo, Hisao

WEKO 15823

en Seo, Hisao

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
キーワード
主題Scheme Other
主題 Muscle atrophy
キーワード
主題Scheme Other
主題 GAPDH
キーワード
主題Scheme Other
主題 ZAKI-4β
キーワード
主題Scheme Other
主題 Tail-suspension
抄録
内容記述 Disuse atrophy of skeletal muscle is a serious complication for a number of bed-ridden patients. We previously demonstrated that unloading of hindlimb muscles by rat tail-suspension for 7 days resulted in disuse atrophy. This is characterized by the change from slow-twitch-oxidative to fast-twitch-glycolytic muscle fibers. Glyceraldehyde-3 phosphate dehydrogenase (GAPDH) is an important glycolytic enzyme in muscles. On the other hand calcineurin (Cn) plays important roles to change fiber subtypes of skeletal muscle. Since we have recently demonstrated that ZAKI-4β, an inhibitor of Cn, is expressed in skeletal muscles, we investigated the changes in the expression of GAPDH and ZAKI-4β mRNA after 7 days of tail-suspension in rats. It reduced the body weight gain (20g) which was about one third of that of control group (60g). Thus the weights of muscles were corrected by body weight. The weight of gastrocnemius and soleus decreased significantly by the tail suspension. In the control group, abundance of GAPDH mRNA in the gastrocnemius was ten times higher than that in soleus. Tail-suspension significantly increased the abundance of GAPDH mRNA in solues. The same tendency was observed in gastrocnemius without statistical significance. In the control group, the levels of ZAKI-4β mRNA in the soleus was about five times higher than that in gastrocnemius. In the suspended group, ZAKI-4β mRNA in the gastrocnemius decreased significantly but did not change in the soleus. The results of GAPDH mRNA suggest that fast-glycolytic fibers are more abundant in gastrocnemius than that in soleus before suspension and tail-suspension increased the ratio of this fiber type in soleus. On the other hand, ZAKI-4β mRNA seems to be expressed selectively in slow-twitch-oxidative fibers, which is compatible with the decreased ratio of slow-twitch fiber in gastrocnemius after the tail-suspension.
言語 en
内容記述タイプ Abstract
内容記述
内容記述 国立情報学研究所で電子化したコンテンツを使用している。
言語 ja
内容記述タイプ Other
出版者
言語 en
出版者 Research Institute of Environmental Medicine, Nagoya University
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
ID登録
ID登録 10.18999/envm.47.15
ID登録タイプ JaLC
ISSN(print)
収録物識別子タイプ PISSN
収録物識別子 0287-0517
書誌情報 en : Environmental Medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University

巻 47, p. 15-19, 発行日 2003-12
フォーマット
application/pdf
著者版フラグ
値 publisher
URI
識別子 http://hdl.handle.net/2237/7561
識別子タイプ HDL
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