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Involvement of Alpha1-adrenoceptors in the Cutaneous Blood Flow Increase Response to Sympathetic Nerve Stimulation in Rats with Chronic Constriction Injury
https://doi.org/10.18999/envm.47.31
https://doi.org/10.18999/envm.47.31f8b63e4d-244b-4f28-9068-30cd74d5be7d
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
31-34.pdf (383.5 kB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2007-04-05 | |||||
| タイトル | ||||||
| タイトル | Involvement of Alpha1-adrenoceptors in the Cutaneous Blood Flow Increase Response to Sympathetic Nerve Stimulation in Rats with Chronic Constriction Injury | |||||
| 言語 | en | |||||
| 著者 |
Koeda, Tomoko
× Koeda, Tomoko× Sato, Jun× Mizumura, Kazue |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | sympathetic nerve stimulation | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | neuropathic pain | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | blood flow | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | rats | |||||
| 抄録 | ||||||
| 内容記述 | There is some evidence that the sympathetic nervous system plays a role in the development and/or maintenance of painful states, and that sympathetic nervous function is altered in these conditions. Our previous experiments showed that electrical stimulation of the lumbar sympathetic trunk (sympathetic stimulation: SS), which normally induces a decrease in blood flow (BF), induced a BF increase in all adjuvant-inflamed rats. Such rats are one model of persistent pain. This mechanism for the BF-increase response to SS involves both α-adrenergic and non-adrenergic receptors. In the present experiment we examined whether BF was increased by SS in another animal model of pain, which was produced by placing loosely tied ligatures around the common sciatic nerve, and whether the BF response involved the α1-adrenoceptor. We found SS induced both increased and decreased BF responses in this pain model. Both responses were inhibited by α1-adrenoceptor antagonist. This result suggests the possibility that the plantar BF-increase response occurs as a secondary effect following vasoconstriction at another site. | |||||
| 言語 | en | |||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | ||||||
| 内容記述 | 国立情報学研究所で電子化したコンテンツを使用している。 | |||||
| 言語 | ja | |||||
| 内容記述タイプ | Other | |||||
| 出版者 | ||||||
| 言語 | en | |||||
| 出版者 | Research Institute of Environmental Medicine, Nagoya University | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | departmental bulletin paper | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| ID登録 | ||||||
| ID登録 | 10.18999/envm.47.31 | |||||
| ID登録タイプ | JaLC | |||||
| ISSN（print） | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0287-0517 | |||||
| 書誌情報 |
en : Environmental Medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University 巻 47, p. 31-34, 発行日 2003-12 |
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| フォーマット | ||||||
| application/pdf | ||||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
| URI | ||||||
| 識別子 | http://hdl.handle.net/2237/7568 | |||||
| 識別子タイプ | HDL | |||||
