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  1. F100 環境医学研究所
  2. F100b 紀要
  3. Environmental medicine : annual report of the Research Institute of Environmental Medicine
  4. 47

The Difference of mRNA Expression of ATP-Sensitive K^+ Channel Subunits in Embryonic and Adult Mouse Heart

https://doi.org/10.18999/envm.47.35
https://doi.org/10.18999/envm.47.35
004993a2-0b27-4ac9-a5a4-38f8a3c34d88
名前 / ファイル ライセンス アクション
35-36.pdf 35-36.pdf (184.2 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2007-04-05
タイトル
タイトル The Difference of mRNA Expression of ATP-Sensitive K^+ Channel Subunits in Embryonic and Adult Mouse Heart
言語 en
著者 Yasui, Kenji

× Yasui, Kenji

WEKO 15853

en Yasui, Kenji

Search repository
Hojo, Mayumi

× Hojo, Mayumi

WEKO 15854

en Hojo, Mayumi

Search repository
Kodama, Itsuo

× Kodama, Itsuo

WEKO 15855

en Kodama, Itsuo

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
キーワード
主題Scheme Other
主題 ATP-sensitive K channel
キーワード
主題Scheme Other
主題 mRNA
キーワード
主題Scheme Other
主題 mouse
キーワード
主題Scheme Other
主題 heart
抄録
内容記述 ATP-sensitive K^+(K_<ATP>) channels is expressed in early-stage embryonic heart as well as at the adult stage. K_<ATP> channels are composed of pore-forming (Kir) and regulatory sulfonylurea receptor (SUR) subunits. We studied mRNA expression of Kir6.1, Kir6.2, SUR1, SUR2A, SUR2B and SUR2C mRNAs encoding for K_(ATP) channels in cardiac ventricles of embryonic (9.5 days postcoitum, dpc) and adult mice using RT-PCR. 30 cycles of PCR revealed mRNA expression of all genes at the adult-stage. At 9.5 dpc, Kir6.1 mRNA was undetectable, whereas mRNAs of other subunits were detected. At 9.5 dpc, SUR2A expression was higher than SUR1 and SUR2B. In the adulthood, mRNAs of all subunits were detected. This finding suggests that Kir6.2 is dominant pore-forming subunit from an early embryonic stage. The developmental changes of transcriptional profile of K_(ATP) channels may underlie the different functional properties of the channel in pre-and post-natal period.
言語 en
内容記述タイプ Abstract
内容記述
内容記述 国立情報学研究所で電子化したコンテンツを使用している。
言語 ja
内容記述タイプ Other
出版者
言語 en
出版者 Research Institute of Environmental Medicine, Nagoya University
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
ID登録
ID登録 10.18999/envm.47.35
ID登録タイプ JaLC
ISSN(print)
収録物識別子タイプ PISSN
収録物識別子 0287-0517
書誌情報 en : Environmental Medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University

巻 47, p. 35-36, 発行日 2003-12
フォーマット
application/pdf
著者版フラグ
値 publisher
URI
識別子 http://hdl.handle.net/2237/7570
識別子タイプ HDL
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