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The Difference of mRNA Expression of ATP-Sensitive K^+ Channel Subunits in Embryonic and Adult Mouse Heart
https://doi.org/10.18999/envm.47.35
https://doi.org/10.18999/envm.47.35004993a2-0b27-4ac9-a5a4-38f8a3c34d88
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
35-36.pdf (184.2 kB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2007-04-05 | |||||
| タイトル | ||||||
| タイトル | The Difference of mRNA Expression of ATP-Sensitive K^+ Channel Subunits in Embryonic and Adult Mouse Heart | |||||
| 言語 | en | |||||
| 著者 |
Yasui, Kenji
× Yasui, Kenji× Hojo, Mayumi× Kodama, Itsuo |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | ATP-sensitive K channel | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | mRNA | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | mouse | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | heart | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | ATP-sensitive K^+(K_<ATP>) channels is expressed in early-stage embryonic heart as well as at the adult stage. Ｋ_<ATP> channels are composed of pore-forming (Kir) and regulatory sulfonylurea receptor (SUR) subunits. We studied mRNA expression of Kir6.1, Kir6.2, SUR1, SUR2A, SUR2B and SUR2C mRNAs encoding for K_(ATP) channels in cardiac ventricles of embryonic (9.5 days postcoitum, dpc) and adult mice using RT-PCR. 30 cycles of PCR revealed mRNA expression of all genes at the adult-stage. At 9.5 dpc, Kir6.1 mRNA was undetectable, whereas mRNAs of other subunits were detected. At 9.5 dpc, SUR2A expression was higher than SUR1 and SUR2B. In the adulthood, mRNAs of all subunits were detected. This finding suggests that Kir6.2 is dominant pore-forming subunit from an early embryonic stage. The developmental changes of transcriptional profile of K_(ATP) channels may underlie the different functional properties of the channel in pre-and post-natal period. | |||||
| 言語 | en | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 国立情報学研究所で電子化したコンテンツを使用している。 | |||||
| 言語 | ja | |||||
| 出版者 | ||||||
| 出版者 | Research Institute of Environmental Medicine, Nagoya University | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| ID登録 | ||||||
| ID登録 | 10.18999/envm.47.35 | |||||
| ID登録タイプ | JaLC | |||||
| ISSN（print） | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0287-0517 | |||||
| 書誌情報 |
en : Environmental Medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University 巻 47, p. 35-36, 発行日 2003-12 |
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| フォーマット | ||||||
| 値 | application/pdf | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
| URI | ||||||
| 識別子 | http://hdl.handle.net/2237/7570 | |||||
| 識別子タイプ | HDL | |||||
