{"_buckets": {"deposit": "8d93039b-6340-448e-9074-d058b0c62e61"}, "_deposit": {"id": "5972", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "5972"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00005972"}, "item_9_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2003-12", "bibliographicIssueDateType": "Issued"}, "bibliographicPageEnd": "55", "bibliographicPageStart": "53", "bibliographicVolumeNumber": "47", "bibliographic_titles": [{"bibliographic_title": "Environmental Medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University"}]}]}, "item_9_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Amiodarone is a potent antiarrhythmic agent in the treatment of the atrial fibrillation and flutter. However, underlying electrophysiological mechanism are not clarified yet. In the present study, we investigated the acute effects of amiodarone on the action potentials in rabbit atrial myocytes. Amiodarone (10\u03bcM) prolonged the action potential durations (APDs) at lower stimulation frequencies (e.g. 38\u00b18 ms control vs. 45\u00b16 ms amiodarone at 0.1 Hz, n=3, P\u003c0.05). In contrast, amiodarone shortened the APDs at higher frequencies (e.g. 81\u00b111 ms control vs. 25\u00b110 ms amiodarone at 3.0 Hz, n=3, P\u003c0.05). These results suggest that the antiarrhythmic action of amiodarone on atrial arrhythmias exhibits frequency-dependence.", "subitem_description_type": "Abstract"}]}, "item_9_description_5": {"attribute_name": "\u5185\u5bb9\u8a18\u8ff0", "attribute_value_mlt": [{"subitem_description": "\u56fd\u7acb\u60c5\u5831\u5b66\u7814\u7a76\u6240\u3067\u96fb\u5b50\u5316\u3057\u305f\u30b3\u30f3\u30c6\u30f3\u30c4\u3092\u4f7f\u7528\u3057\u3066\u3044\u308b\u3002", "subitem_description_type": "Other"}]}, "item_9_identifier_60": {"attribute_name": "URI", "attribute_value_mlt": [{"subitem_identifier_type": "HDL", "subitem_identifier_uri": "http://hdl.handle.net/2237/7589"}]}, "item_9_identifier_registration": {"attribute_name": "ID\u767b\u9332", "attribute_value_mlt": [{"subitem_identifier_reg_text": "10.18999/envm.47.53", "subitem_identifier_reg_type": "JaLC"}]}, "item_9_publisher_32": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Research Institute of Environmental Medicine, Nagoya University"}]}, "item_9_select_15": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_9_source_id_7": {"attribute_name": "ISSN\uff08print\uff09", "attribute_value_mlt": [{"subitem_source_identifier": "0287-0517", "subitem_source_identifier_type": "ISSN"}]}, "item_9_text_14": {"attribute_name": "\u30d5\u30a9\u30fc\u30de\u30c3\u30c8", "attribute_value_mlt": [{"subitem_text_value": "application/pdf"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Lu, Zhibo"}], "nameIdentifiers": [{"nameIdentifier": "15911", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kamiya, Kaichiro"}], "nameIdentifiers": [{"nameIdentifier": "15912", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-02-19"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "53-55.pdf", "filesize": [{"value": "238.5 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 238500.0, "url": {"label": "53-55.pdf", "url": "https://nagoya.repo.nii.ac.jp/record/5972/files/53-55.pdf"}, "version_id": "858be83d-055e-44f8-ade5-bcc337678524"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "amiodarone", "subitem_subject_scheme": "Other"}, {"subitem_subject": "rabbit", "subitem_subject_scheme": "Other"}, {"subitem_subject": "atrial", "subitem_subject_scheme": "Other"}, {"subitem_subject": "action potential", "subitem_subject_scheme": "Other"}, {"subitem_subject": "frequency dependency", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Effects of Amiodarone on the Electrophysiological Characters of Rabbit Atrial Myocytes", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Effects of Amiodarone on the Electrophysiological Characters of Rabbit Atrial Myocytes"}]}, "item_type_id": "9", "owner": "1", "path": ["329/333/334/737"], "permalink_uri": "https://doi.org/10.18999/envm.47.53", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2007-04-06"}, "publish_date": "2007-04-06", "publish_status": "0", "recid": "5972", "relation": {}, "relation_version_is_last": true, "title": ["Effects of Amiodarone on the Electrophysiological Characters of Rabbit Atrial Myocytes"], "weko_shared_id": null}