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Effects of Amiodarone on the Electrophysiological Characters of Rabbit Atrial Myocytes
https://doi.org/10.18999/envm.47.53
https://doi.org/10.18999/envm.47.53f8a7c85a-87c6-421c-9606-441ce35590a7
名前 / ファイル | ライセンス | アクション |
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2007-04-06 | |||||
タイトル | ||||||
タイトル | Effects of Amiodarone on the Electrophysiological Characters of Rabbit Atrial Myocytes | |||||
言語 | en | |||||
著者 |
Lu, Zhibo
× Lu, Zhibo× Kamiya, Kaichiro |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | amiodarone | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | rabbit | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | atrial | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | action potential | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | frequency dependency | |||||
抄録 | ||||||
内容記述 | Amiodarone is a potent antiarrhythmic agent in the treatment of the atrial fibrillation and flutter. However, underlying electrophysiological mechanism are not clarified yet. In the present study, we investigated the acute effects of amiodarone on the action potentials in rabbit atrial myocytes. Amiodarone (10μM) prolonged the action potential durations (APDs) at lower stimulation frequencies (e.g. 38±8 ms control vs. 45±6 ms amiodarone at 0.1 Hz, n=3, P<0.05). In contrast, amiodarone shortened the APDs at higher frequencies (e.g. 81±11 ms control vs. 25±10 ms amiodarone at 3.0 Hz, n=3, P<0.05). These results suggest that the antiarrhythmic action of amiodarone on atrial arrhythmias exhibits frequency-dependence. | |||||
言語 | en | |||||
内容記述タイプ | Abstract | |||||
内容記述 | ||||||
内容記述 | 国立情報学研究所で電子化したコンテンツを使用している。 | |||||
言語 | ja | |||||
内容記述タイプ | Other | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | Research Institute of Environmental Medicine, Nagoya University | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
ID登録 | ||||||
ID登録 | 10.18999/envm.47.53 | |||||
ID登録タイプ | JaLC | |||||
ISSN(print) | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0287-0517 | |||||
書誌情報 |
en : Environmental Medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University 巻 47, p. 53-55, 発行日 2003-12 |
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フォーマット | ||||||
application/pdf | ||||||
著者版フラグ | ||||||
値 | publisher | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2237/7589 | |||||
識別子タイプ | HDL |