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  1. F100 環境医学研究所
  2. F100a 雑誌掲載論文
  3. 学術雑誌

Changes in Cardiovascular Parameters and Plasma Norepinephrine Level in Rats after Chronic Constriction Injury on the Sciatic Nerve

http://hdl.handle.net/2237/8647
0a09abec-8b2d-4d28-b9d1-657c41979c9f
名前 / ファイル ライセンス アクション
070403.pdf 070403.pdf (94.1 kB)
revised_figs.pdf revised_figs.pdf (850.8 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2007-08-09
タイトル
タイトル Changes in Cardiovascular Parameters and Plasma Norepinephrine Level in Rats after Chronic Constriction Injury on the Sciatic Nerve
著者 Jin, Yu

× Jin, Yu

WEKO 18314

Jin, Yu

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Sato, Jun

× Sato, Jun

WEKO 18315

Sato, Jun

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Yamasaki, Masahiro

× Yamasaki, Masahiro

WEKO 18316

Yamasaki, Masahiro

Search repository
Omura, Sayaka

× Omura, Sayaka

WEKO 18317

Omura, Sayaka

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Funakubo, Megumi

× Funakubo, Megumi

WEKO 18318

Funakubo, Megumi

Search repository
Senoo, Shiori

× Senoo, Shiori

WEKO 18319

Senoo, Shiori

Search repository
Aoyama, Morihiko

× Aoyama, Morihiko

WEKO 18320

Aoyama, Morihiko

Search repository
Mizumura, Kazue

× Mizumura, Kazue

WEKO 18321

Mizumura, Kazue

Search repository
権利
権利情報 This is the author's version of work accepted for publication by Elsevier. Changes resulting from the publishing process, including peer review, editing, corrections, structural formatting and other quality control mechanisms, may not reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Pain, inpress, 2007, http://dx.doi.org/10.1016/j.pain.2007.05.020
抄録
内容記述 To evaluate whether neuropathic pain affects autonomic nervous activities, we investigated daily change in cardiovascular parameters and plasma norepinephrine (NE) in free-moving rats after chronic constriction injury (CCI) on the sciatic nerve. Arterial blood pressure (BP), heart rate (HR), and the power spectrum of pulse interval variability were analyzed. Daily change in motor activity and nociceptive behavior was also measured from some CCI rats. In others, NE from daily blood samples was quantified and spontaneous pain was evaluated by daily monitoring of foot guarding behavior.
We identified three stages in the daily change of cardiovascular parameters and plasma NE level over 3 weeks following CCI. The first stage (up to 3 days after the surgery) was characterized by increased MAP and HR, especially in the daytime, even though plasma NE was unchanged and motor activity decreased. The second stage (mid first to mid second postoperative weeks) was characterized by increased daytime MAP and HR, and the animals developed punctate hyperalgesia in the affected hindpaw. An NE surge that may have been related to spontaneous pain was present 3-5 days after CCI. The third stage, which appeared after the second postoperative week, was characterized by normalized MAP and decreased HR, and increased high-frequency (0.8 - 3.0 Hz) power in pulse interval variability, which is an index of cardiac parasympathetic tone. These results demonstrated that cardiovascular function was kept high through sympathetic and non-sympathetic activity for 2 weeks after CCI, followed by a predominance of parasympathetic tone.
内容記述タイプ Abstract
出版者
出版者 Elsevier
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
DOI
関連識別子
識別子タイプ DOI
関連識別子 http://dx.doi.org/10.1016/j.pain.2007.05.020
ISSN
収録物識別子タイプ ISSN
収録物識別子 0304-3959
書誌情報 Pain

巻 135, 号 3, p. 221-231, 発行日 2007
フォーマット
application/pdf
フォーマット
application/pdf
著者版フラグ
値 author
URI
識別子 http://hdl.handle.net/2237/8647
識別子タイプ HDL
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