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In Vitro Developmental Model of the Gastrointestinal Tract from Mouse Embryonic Stem Cells
https://doi.org/10.18999/nagjms.69.3-4.133
https://doi.org/10.18999/nagjms.69.3-4.13346402427-659d-4ddf-b591-85b2a92fe8b4
名前 / ファイル | ライセンス | アクション |
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p133-137_Torihashi.pdf (496.6 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2007-12-20 | |||||
タイトル | ||||||
タイトル | In Vitro Developmental Model of the Gastrointestinal Tract from Mouse Embryonic Stem Cells | |||||
言語 | en | |||||
著者 |
Torihashi, Shigeko
× Torihashi, Shigeko× Kuwahara, Masaki× Kurahashi, Masaaki |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Gastrointestinal tract | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | in vitro model | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | development | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | embryonic stem cells | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | transcription factors | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | interstitial cells of Cajal | |||||
抄録 | ||||||
内容記述 | Mouse embryonic stem (ES) cells are pluripotent and retain their potential to form cells, tissues and organs originated from three embryonic germ layers. Recently, we developed in vitro organ -gut‐like structures- from mouse ES cells. They had basically similar morphological features to a mouse gastrointestinal tract in vivo composed of three distinct layers (i.e., epithelium, connective tissue and musculature). Gut‐like structures showed spontaneous contractions derived from pacemaker cells (interstitial cells of Cajal) in the musculature. We also examined their formation process and expression pattern of transcription factors crucial for gut organogenesis such as Id2, Sox17, HNF3β/Foxa2 and GATA4. We found that they mimic the development of embryonic gut in vivo and showed a similar expression pattern of common transcription factors. They also maintain their developmental potential after transplantation to a renal capsule. Therefore, gut‐like structures are suitable for in vitro models of gastrointestinal tracts and their development. In addition, we pointed out several unique features different from gut in vivo that provide useful and advantageous tools to investigate the developmental mechanism of the gastrointestinal tract. | |||||
言語 | en | |||||
内容記述タイプ | Abstract | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | Nagoya University School of Medicine | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
ID登録 | ||||||
ID登録 | 10.18999/nagjms.69.3-4.133 | |||||
ID登録タイプ | JaLC | |||||
ISSN(print) | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0027-7622 | |||||
ISSN(Online) | ||||||
収録物識別子タイプ | EISSN | |||||
収録物識別子 | 2186-3326 | |||||
書誌情報 |
en : Nagoya Journal of Medical Science 巻 69, 号 3-4, p. 133-137, 発行日 2007-10 |
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フォーマット | ||||||
application/pdf | ||||||
著者版フラグ | ||||||
値 | publisher | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2237/9187 | |||||
識別子タイプ | HDL |