{"_buckets": {"deposit": "a3c77f03-4be4-4fa2-8b3f-b9d11ea2a174"}, "_deposit": {"id": "7505", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "7505"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00007505"}, "item_9_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2007-10", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "3-4", "bibliographicPageEnd": "137", "bibliographicPageStart": "133", "bibliographicVolumeNumber": "69", "bibliographic_titles": [{"bibliographic_title": "Nagoya Journal of Medical Science"}]}]}, "item_9_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Mouse embryonic stem (ES) cells are pluripotent and retain their potential to form cells, tissues and organs originated from three embryonic germ layers. Recently, we developed in vitro organ -gut\u2010like structures- from mouse ES cells. They had basically similar morphological features to a mouse gastrointestinal tract in vivo composed of three distinct layers (i.e., epithelium, connective tissue and musculature). Gut\u2010like structures showed spontaneous contractions derived from pacemaker cells (interstitial cells of Cajal) in the musculature. We also examined their formation process and expression pattern of transcription factors crucial for gut organogenesis such as Id2, Sox17, HNF3\u03b2/Foxa2 and GATA4. We found that they mimic the development of embryonic gut in vivo and showed a similar expression pattern of common transcription factors. They also maintain their developmental potential after transplantation to a renal capsule. Therefore, gut\u2010like structures are suitable for in vitro models of gastrointestinal tracts and their development. In addition, we pointed out several unique features different from gut in vivo that provide useful and advantageous tools to investigate the developmental mechanism of the gastrointestinal tract.", "subitem_description_type": "Abstract"}]}, "item_9_identifier_60": {"attribute_name": "URI", "attribute_value_mlt": [{"subitem_identifier_type": "HDL", "subitem_identifier_uri": "http://hdl.handle.net/2237/9187"}]}, "item_9_identifier_registration": {"attribute_name": "ID\u767b\u9332", "attribute_value_mlt": [{"subitem_identifier_reg_text": "10.18999/nagjms.69.3-4.133", "subitem_identifier_reg_type": "JaLC"}]}, "item_9_publisher_32": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Nagoya University School of Medicine"}]}, "item_9_select_15": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_9_source_id_7": {"attribute_name": "ISSN\uff08print\uff09", "attribute_value_mlt": [{"subitem_source_identifier": "0027-7622", "subitem_source_identifier_type": "ISSN"}]}, "item_9_text_14": {"attribute_name": "\u30d5\u30a9\u30fc\u30de\u30c3\u30c8", "attribute_value_mlt": [{"subitem_text_value": "application/pdf"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Torihashi, Shigeko"}], "nameIdentifiers": [{"nameIdentifier": "21077", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kuwahara, Masaki"}], "nameIdentifiers": [{"nameIdentifier": "21078", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kurahashi, Masaaki"}], "nameIdentifiers": [{"nameIdentifier": "21079", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-02-19"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "p133-137_Torihashi.pdf", "filesize": [{"value": "496.6 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 496600.0, "url": {"label": "p133-137_Torihashi.pdf", "url": "https://nagoya.repo.nii.ac.jp/record/7505/files/p133-137_Torihashi.pdf"}, "version_id": "976951dd-d226-468f-bd04-09b978cb6ea2"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "Gastrointestinal tract", "subitem_subject_scheme": "Other"}, {"subitem_subject": "in vitro model", "subitem_subject_scheme": "Other"}, {"subitem_subject": "development", "subitem_subject_scheme": "Other"}, {"subitem_subject": "embryonic stem cells", "subitem_subject_scheme": "Other"}, {"subitem_subject": "transcription factors", "subitem_subject_scheme": "Other"}, {"subitem_subject": "interstitial cells of Cajal", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "In Vitro Developmental Model of the Gastrointestinal Tract from Mouse Embryonic Stem Cells", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "In Vitro Developmental Model of the Gastrointestinal Tract from Mouse Embryonic Stem Cells"}]}, "item_type_id": "9", "owner": "1", "path": ["499/508/509/917"], "permalink_uri": "https://doi.org/10.18999/nagjms.69.3-4.133", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2007-12-20"}, "publish_date": "2007-12-20", "publish_status": "0", "recid": "7505", "relation": {}, "relation_version_is_last": true, "title": ["In Vitro Developmental Model of the Gastrointestinal Tract from Mouse Embryonic Stem Cells"], "weko_shared_id": null}