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  1. B300 農学部/生命農学研究科
  2. B300a 雑誌掲載論文
  3. 学術雑誌

Further mapping of quantitative trait loci for postnatal growth in an intersubspecific backcross of wild Mus musculus castaneus and C57BL/6J mice

http://hdl.handle.net/2237/10290
http://hdl.handle.net/2237/10290
41aeda36-d07f-4335-84d3-f81709054669
名前 / ファイル ライセンス アクション
Ishikawa_Akira_Further_mapping_of_quantitative_trait_loci_for_postnatal_2005.pdf Ishikawa_Akira_Further_mapping_of_quantitative_trait_loci_for_postnatal_2005.pdf (220.9 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2008-07-29
タイトル
タイトル Further mapping of quantitative trait loci for postnatal growth in an intersubspecific backcross of wild Mus musculus castaneus and C57BL/6J mice
言語 en
著者 ISHIKAWA, AKIRA

× ISHIKAWA, AKIRA

WEKO 23996

en ISHIKAWA, AKIRA

Search repository
HATADA, SAYURI

× HATADA, SAYURI

WEKO 23997

en HATADA, SAYURI

Search repository
NAGAMINE, YOSHITAKA

× NAGAMINE, YOSHITAKA

WEKO 23998

en NAGAMINE, YOSHITAKA

Search repository
NAMIKAWA, TAKAO

× NAMIKAWA, TAKAO

WEKO 23999

en NAMIKAWA, TAKAO

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 Cambridge University Press
抄録
内容記述 We performed a quantitative trait locus (QTL) analysis of eight body weights recorded weekly from 3 weeks to 10 weeks after birth and two weight gains recorded between 3 weeks and 6 weeks, and between 6 weeks and 10 weeks in an intersubspecific backcross population of wild Mus musculus castaneus mice captured in the Philippines and the common inbred strain C57BL/6J (M. musculus domesticus), to elucidate the complex genetic architecture of body weight and growth. Interval mapping identified 17 significant QTLs with main effects on 11 chromosomes. In particular, the main effect of the most potent QTL on proximal chromosome 2 increased linearly with age, whereas other QTLs exerted effects on either the early or late growth period. Surprisingly, although wild mice displayed 60% of the body size of their C57BL/6J counterparts, the wild-derived allele enhanced growth at two QTLs. Interestingly, five of the 17 main-effect QTLs identified had significant epistatic interaction effects. Five new epistatic QTLs with no main effects were identified on different chromosomes or regions. For one pair of epistatic QTLs, mice that were heterozygous for the wild-derived allele at one QTL and homozygous for that allele at another QTL exhibited the most rapid growth in all four possible genotypic combinations. Out of the identified QTLs, several showed significant sex-specific effects.
言語 en
内容記述タイプ Abstract
出版者
言語 en
出版者 Cambridge University Press
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1017/S001667230500738X
ISSN
収録物識別子タイプ PISSN
収録物識別子 0016-6723
書誌情報 en : Genetical Research

巻 85, 号 2, p. 127-137, 発行日 2005-08
フォーマット
application/pdf
著者版フラグ
値 publisher
URI
識別子 http://hdl.handle.net/2237/10290
識別子タイプ HDL
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