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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 70(3-4)

PRO-ADDICTIVE AND ANTI-ADDICTIVE FACTORS FOR DRUG DEPENDENCE

https://doi.org/10.18999/nagjms.70.3-4.67
https://doi.org/10.18999/nagjms.70.3-4.67
829f09fc-01e3-4a63-8b7e-d49d4169a038
名前 / ファイル ライセンス アクション
p067-072_Yamada.pdf p067-072_Yamada.pdf (66.2 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2008-09-22
タイトル
タイトル PRO-ADDICTIVE AND ANTI-ADDICTIVE FACTORS FOR DRUG DEPENDENCE
著者 YAMADA, KIYOFUMI

× YAMADA, KIYOFUMI

WEKO 24724

YAMADA, KIYOFUMI

Search repository
キーワード
主題Scheme Other
主題 Drug dependence
キーワード
主題Scheme Other
主題 tPA
キーワード
主題Scheme Other
主題 MMP
キーワード
主題Scheme Other
主題 TNF-α
キーワード
主題Scheme Other
主題 GDNF
抄録
内容記述 Drug dependence is defined as a chronically relapsing disorder that is characterized by compulsive drug taking, inability to limit intake, and intense drug cravings. The positive reinforcing/rewarding effects of drugs primarily depend on the mesocorticolimbic dopamine system innervating the nucleus accumbens while the craving for drugs is associated with activation of the prefrontal cortex. The chronic intake of drugs causes homeostatic molecular and functional changes in synapses, which may be critically associated with the development of drug dependence. Recent studies have demonstrated that various cytokines and proteinases are produced in the brain on treatment with drugs of abuse, and play a role in drug dependence. These endogenous modulators of drug dependence are divided into two groups, pro-addictive and anti-addictive factors. The former including tissue plasminogen activator, matrix metalloproteinase (MMP)-2 and MMP-9 act to potentiate the rewarding effects of drugs, while the latter such as tumor necrosis factor-α and glial cell line-derived neurotrophic factor reduce the reward. These findings suggest that an imbalance between pro-addictive and anti-addictive factors contributes to the development and relapse of drug dependence. Targeting these endogenous modulators would provide new therapeutic approaches to the treatment of drug dependence.
内容記述タイプ Abstract
出版者
出版者 Nagoya University School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.70.3-4.67
ID登録タイプ JaLC
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
書誌情報 Nagoya Journal of Medical Science

巻 70, 号 3-4, p. 67-72, 発行日 2008-08
フォーマット
application/pdf
著者版フラグ
値 publisher
URI
識別子 http://hdl.handle.net/2237/10542
識別子タイプ HDL
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