{"_buckets": {"deposit": "b62e6b40-6e0f-485e-ac6c-70415a65828a"}, "_deposit": {"id": "8855", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "8855"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00008855", "sets": ["331"]}, "author_link": ["24908", "24909", "24910", "24911", "24912", "24913", "24914", "24915", "24916", "24917", "24918", "24919", "24920", "24921", "24922", "24923", "24924", "24925", "24926", "24927"], "control_number": "8855", "item_10_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2008", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "2", "bibliographicPageEnd": "418", "bibliographicPageStart": "413", "bibliographicVolumeNumber": "377", "bibliographic_titles": [{"bibliographic_title": "Biochemical and Biophysical Research Communications", "bibliographic_titleLang": "en"}]}]}, "item_10_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "For myocardial regeneration therapy, the low differentiation capability of functional cardiomyocytes sufficient to replace the damaged myocardial tissue is one of the major difficulties. Using Nkx2.5-GFP knock-in ES cells, we show a new efficient method to obtain cardiomyocytes from embryonic stem (ES) cells. The proportion of GFP-positive cells was significantly increased when ES cells were cultured with a conditioned medium from aortic endothelial cells (ECs), accompanied by upregulation of cardiac-specific genes as well as other mesodermal genes. The promotion was more prominent when EC-conditioned medium was added at an early stage of ES cell differentiation culture (Day 0–3). Inhibitors of bone morphogenic protein (BMP), cyclooxygenase (COX), and nitric oxide synthetase (NO) prevented the promotion of cardiomyogenesis by EC-conditioned medium. These results suggest that supplementation of EC-conditioned medium enables cardiomyocytes to be obtained efficiently through promotion of mesoderm induction, which is regulated by BMP, COX, and NOS.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_10_identifier_60": {"attribute_name": "URI", "attribute_value_mlt": [{"subitem_identifier_type": "HDL", "subitem_identifier_uri": "http://hdl.handle.net/2237/10608"}]}, "item_10_publisher_32": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Elsevier", "subitem_publisher_language": "en"}]}, "item_10_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1016/j.bbrc.2008.09.160", "subitem_relation_type_select": "DOI"}}]}, "item_10_rights_12": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "This is the author\u0027s version of work accepted for publication by Elsevier. Changes resulting from the publishing process, including peer review, editing, corrections, structural formatting and other quality control mechanisms, may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in [Biochemical and Biophysical Research Communications, Article in Press, DOI:10.1016/j.bbrc.2008.09.160]", "subitem_rights_language": "en"}]}, "item_10_select_15": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_10_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0006291X", "subitem_source_identifier_type": "PISSN"}]}, "item_10_text_14": {"attribute_name": "フォーマット", "attribute_value_mlt": [{"subitem_text_value": "application/pdf"}]}, "item_1615787544753": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "角, 三和子", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "24908", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kado, Miwako", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "24909", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "李, 鍾國", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "24910", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Lee, Jong-Kook", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "24911", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "日高, 京子", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "24912", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hidaka, Kyoko", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "24913", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "三輪, 佳子", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "24914", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Miwa, Keiko", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "24915", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "室原, 豊明", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "24916", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Murohara, Toyoaki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "24917", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "笠井, 謙次", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "24918", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kasai, Kenji", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "24919", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "佐賀, 信介", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "24920", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Saga, Shinsuke", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "24921", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "森崎, 隆幸", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "24922", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Morisaki, Takayuki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "24923", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "上田, 裕一", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "24924", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ueda, Yuichi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "24925", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "児玉, 逸雄", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "24926", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kodama, Itsuo", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "24927", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-02-19"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Paracrine_factors_of_vascular_endothelial_cells_facilitate_cardiomyocyte_differentiation_of_mouse_embryonic_stem_cells.pdf", "filesize": [{"value": "682.8 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 682800.0, "url": {"label": "Paracrine_factors_of_vascular_endothelial_cells_facilitate_cardiomyocyte_differentiation_of_mouse_embryonic_stem_cells.pdf", "objectType": "fulltext", "url": "https://nagoya.repo.nii.ac.jp/record/8855/files/Paracrine_factors_of_vascular_endothelial_cells_facilitate_cardiomyocyte_differentiation_of_mouse_embryonic_stem_cells.pdf"}, "version_id": "32464d0c-ea19-4356-9b0b-abf705c4c9de"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Embryonic stem cell", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Cardiac cell", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Vascular endothelial cell", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Paracrine factor", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Cardiomyogenesis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Nkx2.5", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Bone morphogenic protein", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Wnt", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Cyclooxygenase", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Nitric oxide synthase", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Paracrine factors of vascular endothelial cells facilitate cardiomyocyte differentiation of mouse embryonic stem cells", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Paracrine factors of vascular endothelial cells facilitate cardiomyocyte differentiation of mouse embryonic stem cells", "subitem_title_language": "en"}]}, "item_type_id": "10", "owner": "1", "path": ["331"], "permalink_uri": "http://hdl.handle.net/2237/10608", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2008-10-20"}, "publish_date": "2008-10-20", "publish_status": "0", "recid": "8855", "relation": {}, "relation_version_is_last": true, "title": ["Paracrine factors of vascular endothelial cells facilitate cardiomyocyte differentiation of mouse embryonic stem cells"], "weko_shared_id": 3}