{"_buckets": {"deposit": "d0ae9a01-015e-4c41-a6a2-dd03da3c6d6a"}, "_deposit": {"id": "9096", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "9096"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00009096", "sets": ["501"]}, "author_link": ["25516", "25517", "25518", "25519"], "item_10_alternative_title_19": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "Gene Therapy for Malignant Glioma", "subitem_alternative_title_language": "en"}]}, "item_10_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2003-05", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "5", "bibliographicPageEnd": "354", "bibliographicPageStart": "350", "bibliographicVolumeNumber": "12", "bibliographic_titles": [{"bibliographic_title": "脳神経外科ジャーナル", "bibliographic_titleLang": "ja"}]}]}, "item_10_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "遺伝子治療は1990年に米国でスタートし,これまでに600以上のプロトコールで, 4,000人を超える患者に施行されてきた. 1992年には,単純ヘルペスウイルスチミジンキナーゼ遺伝子とガンシクロビルを用いた悪性脳腫瘍に対する初めての遺伝子治療(自殺遺伝子療法)が始まった.現在,この遺伝子治療は第3相試験に入っている.一方,筆者らは,悪性グリオーマに対し,わが国初の純国産遺伝子治療を2000年4月に開始した.この遺伝子治療はリポソームに包埋したインターフェロン遺伝子を使った免疫遺伝子治療である.これまでに5症例に対して治療を施行し,その安全性と有効性を検討している.ここでは自験例も含め,悪性脳腫瘍に対する遺伝子治療の歴史と現状,そして将来展望について紹介する. ", "subitem_description_language": "ja", "subitem_description_type": "Abstract"}, {"subitem_description": "The core technology of advanced medicines provided us opportunities of gene therapy for cancer patients and there are a rapidly growing number of cancer gene therapies worldwide. For malignant brain tumors, a suicide gene therapy using herpes simplex virus thymidine kinase gene and ganciclovir was opened in USA in 1992. Recently, we made a gene therapy protocol of our own, which used cationic multilamellar liposomes entrapped with inter-feron-β(IFN-β)gene as a vector. In April 2000, we started clinical trial of IFN-βgene therapy for the patients with malignant glioma. Until now, 5 patients received the treatment and then they are under evaluation on safety and usefulness. Here we introduce history, present, and prospect of gene therapy for malignant brain tumors.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_10_identifier_60": {"attribute_name": "URI", "attribute_value_mlt": [{"subitem_identifier_type": "HDL", "subitem_identifier_uri": "http://hdl.handle.net/2237/10863"}]}, "item_10_publisher_32": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "日本脳神経外科コングレス", "subitem_publisher_language": "ja"}]}, "item_10_relation_43": {"attribute_name": "関連情報", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://ci.nii.ac.jp/naid/110003813847/", "subitem_relation_type_select": "URI"}}]}, "item_10_rights_12": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "日本脳神経外科コングレス", "subitem_rights_language": "ja"}, {"subitem_rights": "本文データは学協会の許諾に基づきCiNiiから複製したものである", "subitem_rights_language": "ja"}]}, "item_10_select_15": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_10_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0917950X", "subitem_source_identifier_type": "PISSN"}]}, "item_10_text_14": {"attribute_name": "フォーマット", "attribute_value_mlt": [{"subitem_text_value": "application/pdf"}]}, "item_1615787544753": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "水野, 正明", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "25516", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "吉田, 純", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "25517", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Mizuno, Masaaki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "25518", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yoshida, Jun", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "25519", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-02-19"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "mizuno_1210.pdf", "filesize": [{"value": "1.1 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 1100000.0, "url": {"label": "mizuno_1210.pdf", "objectType": "fulltext", "url": "https://nagoya.repo.nii.ac.jp/record/9096/files/mizuno_1210.pdf"}, "version_id": "1d9efc05-ab42-4603-805b-5e4dc1ae8b4b"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "gene therapy", "subitem_subject_scheme": "Other"}, {"subitem_subject": "malignant glioma", "subitem_subject_scheme": "Other"}, {"subitem_subject": "suicide gene therapy", "subitem_subject_scheme": "Other"}, {"subitem_subject": "immuno-gene therapy", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "脳腫瘍の遺伝子治療", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "脳腫瘍の遺伝子治療", "subitem_title_language": "ja"}]}, "item_type_id": "10", "owner": "1", "path": ["501"], "permalink_uri": "http://hdl.handle.net/2237/10863", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2009-01-21"}, "publish_date": "2009-01-21", "publish_status": "0", "recid": "9096", "relation": {}, "relation_version_is_last": true, "title": ["脳腫瘍の遺伝子治療"], "weko_shared_id": -1}