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The core technology of advanced medicines provided us opportunities of gene therapy for cancer patients and there are a rapidly growing number of cancer gene therapies worldwide. For malignant brain tumors, a suicide gene therapy using herpes simplex virus thymidine kinase gene and ganciclovir was opened in USA in 1992. Recently, we made a gene therapy protocol of our own, which used cationic multilamellar liposomes entrapped with inter-feron-\u03b2(IFN-\u03b2)gene as a vector. In April 2000, we started clinical trial of IFN-\u03b2gene therapy for the patients with malignant glioma. Until now, 5 patients received the treatment and then they are under evaluation on safety and usefulness. Here we introduce history, present, and prospect of gene therapy for malignant brain tumors.", "subitem_description_type": "Abstract"}]}, "item_10_identifier_60": {"attribute_name": "URI", "attribute_value_mlt": [{"subitem_identifier_type": "HDL", "subitem_identifier_uri": "http://hdl.handle.net/2237/10863"}]}, "item_10_publisher_32": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "\u65e5\u672c\u8133\u795e\u7d4c\u5916\u79d1\u30b3\u30f3\u30b0\u30ec\u30b9"}]}, "item_10_relation_43": {"attribute_name": "\u7570\u7248\u3067\u3042\u308b", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://ci.nii.ac.jp/naid/110003813847/", "subitem_relation_type_select": "URI"}}]}, "item_10_rights_12": {"attribute_name": "\u6a29\u5229", "attribute_value_mlt": [{"subitem_rights": "\u65e5\u672c\u8133\u795e\u7d4c\u5916\u79d1\u30b3\u30f3\u30b0\u30ec\u30b9"}, {"subitem_rights": "\u672c\u6587\u30c7\u30fc\u30bf\u306f\u5b66\u5354\u4f1a\u306e\u8a31\u8afe\u306b\u57fa\u3065\u304dCiNii\u304b\u3089\u8907\u88fd\u3057\u305f\u3082\u306e\u3067\u3042\u308b"}]}, "item_10_select_15": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_10_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0917950X", "subitem_source_identifier_type": "ISSN"}]}, "item_10_text_14": {"attribute_name": "\u30d5\u30a9\u30fc\u30de\u30c3\u30c8", "attribute_value_mlt": [{"subitem_text_value": "application/pdf"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u6c34\u91ce, \u6b63\u660e"}], "nameIdentifiers": [{"nameIdentifier": "25516", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "\u5409\u7530, \u7d14"}], "nameIdentifiers": [{"nameIdentifier": "25517", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Mizuno, Masaaki"}], "nameIdentifiers": [{"nameIdentifier": "25518", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yoshida, Jun"}], "nameIdentifiers": [{"nameIdentifier": "25519", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-02-19"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "mizuno_1210.pdf", "filesize": [{"value": "1.1 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1100000.0, "url": {"label": "mizuno_1210.pdf", "url": "https://nagoya.repo.nii.ac.jp/record/9096/files/mizuno_1210.pdf"}, "version_id": "1d9efc05-ab42-4603-805b-5e4dc1ae8b4b"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "gene therapy", "subitem_subject_scheme": "Other"}, {"subitem_subject": "malignant glioma", "subitem_subject_scheme": "Other"}, {"subitem_subject": "suicide gene therapy", "subitem_subject_scheme": "Other"}, {"subitem_subject": "immuno-gene therapy", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "\u8133\u816b\u760d\u306e\u907a\u4f1d\u5b50\u6cbb\u7642", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "\u8133\u816b\u760d\u306e\u907a\u4f1d\u5b50\u6cbb\u7642"}]}, "item_type_id": "10", "owner": "1", "path": ["499/500/501"], "permalink_uri": "http://hdl.handle.net/2237/10863", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_name_i18n": "\u516c\u958b\u65e5", "attribute_value": "2009-01-21"}, "publish_date": "2009-01-21", "publish_status": "0", "recid": "9096", "relation": {}, "relation_version_is_last": true, "title": ["\u8133\u816b\u760d\u306e\u907a\u4f1d\u5b50\u6cbb\u7642"], "weko_shared_id": 3}