{"_buckets": {"deposit": "d0ae9a01-015e-4c41-a6a2-dd03da3c6d6a"}, "_deposit": {"id": "9096", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "9096"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00009096"}, "item_10_alternative_title_19": {"attribute_name": "\u305d\u306e\u4ed6\u306e\u8a00\u8a9e\u306e\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_alternative_title": "Gene Therapy for Malignant Glioma"}]}, "item_10_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2003-05", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "5", "bibliographicPageEnd": "354", "bibliographicPageStart": "350", "bibliographicVolumeNumber": "12", "bibliographic_titles": [{"bibliographic_title": "\u8133\u795e\u7d4c\u5916\u79d1\u30b8\u30e3\u30fc\u30ca\u30eb"}]}]}, "item_10_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "\u907a\u4f1d\u5b50\u6cbb\u7642\u306f1990\u5e74\u306b\u7c73\u56fd\u3067\u30b9\u30bf\u30fc\u30c8\u3057,\u3053\u308c\u307e\u3067\u306b600\u4ee5\u4e0a\u306e\u30d7\u30ed\u30c8\u30b3\u30fc\u30eb\u3067, 4,000\u4eba\u3092\u8d85\u3048\u308b\u60a3\u8005\u306b\u65bd\u884c\u3055\u308c\u3066\u304d\u305f. 1992\u5e74\u306b\u306f,\u5358\u7d14\u30d8\u30eb\u30da\u30b9\u30a6\u30a4\u30eb\u30b9\u30c1\u30df\u30b8\u30f3\u30ad\u30ca\u30fc\u30bc\u907a\u4f1d\u5b50\u3068\u30ac\u30f3\u30b7\u30af\u30ed\u30d3\u30eb\u3092\u7528\u3044\u305f\u60aa\u6027\u8133\u816b\u760d\u306b\u5bfe\u3059\u308b\u521d\u3081\u3066\u306e\u907a\u4f1d\u5b50\u6cbb\u7642(\u81ea\u6bba\u907a\u4f1d\u5b50\u7642\u6cd5)\u304c\u59cb\u307e\u3063\u305f.\u73fe\u5728,\u3053\u306e\u907a\u4f1d\u5b50\u6cbb\u7642\u306f\u7b2c3\u76f8\u8a66\u9a13\u306b\u5165\u3063\u3066\u3044\u308b.\u4e00\u65b9,\u7b46\u8005\u3089\u306f,\u60aa\u6027\u30b0\u30ea\u30aa\u30fc\u30de\u306b\u5bfe\u3057,\u308f\u304c\u56fd\u521d\u306e\u7d14\u56fd\u7523\u907a\u4f1d\u5b50\u6cbb\u7642\u30922000\u5e744\u6708\u306b\u958b\u59cb\u3057\u305f.\u3053\u306e\u907a\u4f1d\u5b50\u6cbb\u7642\u306f\u30ea\u30dd\u30bd\u30fc\u30e0\u306b\u5305\u57cb\u3057\u305f\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3\u907a\u4f1d\u5b50\u3092\u4f7f\u3063\u305f\u514d\u75ab\u907a\u4f1d\u5b50\u6cbb\u7642\u3067\u3042\u308b.\u3053\u308c\u307e\u3067\u306b5\u75c7\u4f8b\u306b\u5bfe\u3057\u3066\u6cbb\u7642\u3092\u65bd\u884c\u3057,\u305d\u306e\u5b89\u5168\u6027\u3068\u6709\u52b9\u6027\u3092\u691c\u8a0e\u3057\u3066\u3044\u308b.\u3053\u3053\u3067\u306f\u81ea\u9a13\u4f8b\u3082\u542b\u3081,\u60aa\u6027\u8133\u816b\u760d\u306b\u5bfe\u3059\u308b\u907a\u4f1d\u5b50\u6cbb\u7642\u306e\u6b74\u53f2\u3068\u73fe\u72b6,\u305d\u3057\u3066\u5c06\u6765\u5c55\u671b\u306b\u3064\u3044\u3066\u7d39\u4ecb\u3059\u308b. The core technology of advanced medicines provided us opportunities of gene therapy for cancer patients and there are a rapidly growing number of cancer gene therapies worldwide. For malignant brain tumors, a suicide gene therapy using herpes simplex virus thymidine kinase gene and ganciclovir was opened in USA in 1992. Recently, we made a gene therapy protocol of our own, which used cationic multilamellar liposomes entrapped with inter-feron-\u03b2(IFN-\u03b2)gene as a vector. In April 2000, we started clinical trial of IFN-\u03b2gene therapy for the patients with malignant glioma. Until now, 5 patients received the treatment and then they are under evaluation on safety and usefulness. Here we introduce history, present, and prospect of gene therapy for malignant brain tumors.", "subitem_description_type": "Abstract"}]}, "item_10_identifier_60": {"attribute_name": "URI", "attribute_value_mlt": [{"subitem_identifier_type": "HDL", "subitem_identifier_uri": "http://hdl.handle.net/2237/10863"}]}, "item_10_publisher_32": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "\u65e5\u672c\u8133\u795e\u7d4c\u5916\u79d1\u30b3\u30f3\u30b0\u30ec\u30b9"}]}, "item_10_relation_43": {"attribute_name": "\u7570\u7248\u3067\u3042\u308b", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://ci.nii.ac.jp/naid/110003813847/", "subitem_relation_type_select": "URI"}}]}, "item_10_rights_12": {"attribute_name": "\u6a29\u5229", "attribute_value_mlt": [{"subitem_rights": "\u65e5\u672c\u8133\u795e\u7d4c\u5916\u79d1\u30b3\u30f3\u30b0\u30ec\u30b9"}, {"subitem_rights": "\u672c\u6587\u30c7\u30fc\u30bf\u306f\u5b66\u5354\u4f1a\u306e\u8a31\u8afe\u306b\u57fa\u3065\u304dCiNii\u304b\u3089\u8907\u88fd\u3057\u305f\u3082\u306e\u3067\u3042\u308b"}]}, "item_10_select_15": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_10_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0917950X", "subitem_source_identifier_type": "ISSN"}]}, "item_10_text_14": {"attribute_name": "\u30d5\u30a9\u30fc\u30de\u30c3\u30c8", "attribute_value_mlt": [{"subitem_text_value": "application/pdf"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u6c34\u91ce, \u6b63\u660e"}], "nameIdentifiers": [{"nameIdentifier": "25516", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "\u5409\u7530, \u7d14"}], "nameIdentifiers": [{"nameIdentifier": "25517", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Mizuno, Masaaki"}], "nameIdentifiers": [{"nameIdentifier": "25518", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yoshida, Jun"}], "nameIdentifiers": [{"nameIdentifier": "25519", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-02-19"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "mizuno_1210.pdf", "filesize": [{"value": "1.1 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1100000.0, "url": {"label": "mizuno_1210.pdf", "url": "https://nagoya.repo.nii.ac.jp/record/9096/files/mizuno_1210.pdf"}, "version_id": "1d9efc05-ab42-4603-805b-5e4dc1ae8b4b"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "gene therapy", "subitem_subject_scheme": "Other"}, {"subitem_subject": "malignant glioma", "subitem_subject_scheme": "Other"}, {"subitem_subject": "suicide gene therapy", "subitem_subject_scheme": "Other"}, {"subitem_subject": "immuno-gene therapy", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "\u8133\u816b\u760d\u306e\u907a\u4f1d\u5b50\u6cbb\u7642", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "\u8133\u816b\u760d\u306e\u907a\u4f1d\u5b50\u6cbb\u7642"}]}, "item_type_id": "10", "owner": "1", "path": ["499/500/501"], "permalink_uri": "http://hdl.handle.net/2237/10863", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2009-01-21"}, "publish_date": "2009-01-21", "publish_status": "0", "recid": "9096", "relation": {}, "relation_version_is_last": true, "title": ["\u8133\u816b\u760d\u306e\u907a\u4f1d\u5b50\u6cbb\u7642"], "weko_shared_id": 3}