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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

High-affinity uptake of kynurenine and nitric oxide-mediated inhibition of indoleamine 2,3-dioxygenase in bone marrow-derived myeloid dendritic cells

http://hdl.handle.net/2237/11381
http://hdl.handle.net/2237/11381
2a5c1be5-91ba-4d69-8a11-4616cb2b476d
名前 / ファイル ライセンス アクション
Kyn_Uptake.pdf Kyn_Uptake.pdf (332.8 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2009-04-01
タイトル
タイトル High-affinity uptake of kynurenine and nitric oxide-mediated inhibition of indoleamine 2,3-dioxygenase in bone marrow-derived myeloid dendritic cells
言語 en
著者 Hara, Toshiaki

× Hara, Toshiaki

WEKO 29166

en Hara, Toshiaki

Search repository
Ogasawara, Nanako

× Ogasawara, Nanako

WEKO 29167

en Ogasawara, Nanako

Search repository
Akimoto, Hidetoshi

× Akimoto, Hidetoshi

WEKO 29168

en Akimoto, Hidetoshi

Search repository
Takikawa, Osamu

× Takikawa, Osamu

WEKO 29169

en Takikawa, Osamu

Search repository
Hiramatsu, Rie

× Hiramatsu, Rie

WEKO 29170

en Hiramatsu, Rie

Search repository
Kawabe, Tsutomu

× Kawabe, Tsutomu

WEKO 29171

en Kawabe, Tsutomu

Search repository
Isobe, Ken-ichi

× Isobe, Ken-ichi

WEKO 29172

en Isobe, Ken-ichi

Search repository
Nagase, Fumihiko

× Nagase, Fumihiko

WEKO 29173

en Nagase, Fumihiko

Search repository
長瀬, 文彦

× 長瀬, 文彦

WEKO 29174

ja 長瀬, 文彦

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
キーワード
主題Scheme Other
主題 Bone marrow-derived myeloid dendritic cells
キーワード
主題Scheme Other
主題 Indoleamine 2,3-dioxygenase
キーワード
主題Scheme Other
主題 Tryptophan
キーワード
主題Scheme Other
主題 Kynurenine
キーワード
主題Scheme Other
主題 Nitric oxide
キーワード
主題Scheme Other
主題 Transport system L
抄録
内容記述 Indoleamine 2,3-dioxygenase (IDO)-initiated tryptophan metabolism along the kynurenine (Kyn) pathway in some dendritic cells (DC) such as plasmacytoid DC regulates T-cell responses. It is unclear whether bone marrow-derived myeloid DC (BMDC) express functional IDO. The IDO expression was examined in CD11c+CD11b+ BMDC differentiated from mouse bone marrow cells using GM-CSF. CpG oligodeoxynucleotides (CpG) induced the expression of IDO protein with the production of nitric oxide (NO) in BMDC in cultures for 24 hr. In the enzyme assay using cellular extracts of BMDC, the IDO activity of BMDC stimulated with CpG was enhanced by the addition of a NO synthase (NOS) inhibitor, suggesting that IDO activity was suppressed by NO production. On the other hand, the concentration of Kyn in the culture supernatant of BMDC was not increased by stimulation with CpG. Exogenously added Kyn was taken up by BMDC independently of CpG stimulation and NO production, and the uptake of Kyn was inhibited by a transport system L-specific inhibitor or high concentrations of tryptophan. The uptake of tryptophan by BMDC was markedly lower than that of Kyn. In conclusion, IDO activity in BMDC is down-regulated by NO production, whereas BMDC strongly take up exogenous Kyn.
言語 en
内容記述タイプ Abstract
出版者
言語 en
出版者 Elsevier
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1016/j.imlet.2007.11.016
ISSN
収録物識別子タイプ PISSN
収録物識別子 01652478
書誌情報 en : Immunology Letters

巻 116, p. 95-102, 発行日 2008-02-15
フォーマット
application/pdf
著者版フラグ
値 author
URI
識別子 http://hdl.handle.net/2237/11381
識別子タイプ HDL
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