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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 71(3-4)

A NOVEL P53-DEPENDENT APOPTOSIS FUNCTION OF TARSH IN TUMOR DEVELOPMENT

https://doi.org/10.18999/nagjms.71.3-4.109
https://doi.org/10.18999/nagjms.71.3-4.109
75b79d6c-a86b-4887-b229-a2fd934ba838
名前 / ファイル ライセンス アクション
p109-114_Wakoh.pdf p109-114_Wakoh.pdf (244.9 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2009-11-30
タイトル
タイトル A NOVEL P53-DEPENDENT APOPTOSIS FUNCTION OF TARSH IN TUMOR DEVELOPMENT
著者 WAKOH, TAKESHI

× WAKOH, TAKESHI

WEKO 31876

WAKOH, TAKESHI

Search repository
SUGIMOTO, MASATAKA

× SUGIMOTO, MASATAKA

WEKO 31877

SUGIMOTO, MASATAKA

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TERAUCHI, KUNIHIKO

× TERAUCHI, KUNIHIKO

WEKO 31878

TERAUCHI, KUNIHIKO

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SHIMADA, JUN-ICHI

× SHIMADA, JUN-ICHI

WEKO 31879

SHIMADA, JUN-ICHI

Search repository
MARUYAMA, MITSUO

× MARUYAMA, MITSUO

WEKO 31880

MARUYAMA, MITSUO

Search repository
キーワード
主題Scheme Other
主題 Cell cycle
キーワード
主題Scheme Other
主題 Apoptosis
キーワード
主題Scheme Other
主題 Tumor suppression
キーワード
主題Scheme Other
主題 TARSH
キーワード
主題Scheme Other
主題 p53
抄録
内容記述 A target of NESH-SH3/Abi3bp (TARSH) was originally identified as an SH3 domain-binding molecule of the NESH-SH3/Abi3 protein that is involved in Rac-dependent actin polymerization. In recent studies, TARSH gene expression was dramatically induced in mouse embryonic fibroblasts (MEFs) replicative senescence and suppressed in human lung carcinoma specimens and thyroid carcinomas. However, the molecular mechanism underlying the regulation of TARSH in tumorigenesis remains unclear. Here, we address a p53-dependent apoptosis function of the mouse TARSH gene using RNAi-mediated suppression of endogenous TARSH expression. Our results will be useful in the discovery of a novel therapeutic
target in lung carcinoma.
内容記述タイプ Abstract
出版者
出版者 Nagoya University School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.71.3-4.109
ID登録タイプ JaLC
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
書誌情報 Nagoya Journal of Medical Science

巻 71, 号 3-4, p. 109-114, 発行日 2009-09
フォーマット
application/pdf
著者版フラグ
値 publisher
URI
識別子 http://hdl.handle.net/2237/12347
識別子タイプ HDL
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