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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 72(1-2)

Uremic Toxicity of Indoxyl Sulfate

https://doi.org/10.18999/nagjms.72.1-2.1
https://doi.org/10.18999/nagjms.72.1-2.1
4439267a-00f0-478e-8844-bd92e2959ad3
名前 / ファイル ライセンス アクション
p001-012_Niwa.pdf p001-012_Niwa.pdf (432.5 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2010-03-11
タイトル
タイトル Uremic Toxicity of Indoxyl Sulfate
著者 Niwa, Toshimitsu

× Niwa, Toshimitsu

WEKO 33472

Niwa, Toshimitsu

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キーワード
主題Scheme Other
主題 Indoxyl sulfate
キーワード
主題Scheme Other
主題 Chronic kidney disease
キーワード
主題Scheme Other
主題 Protein metabolite theory
キーワード
主題Scheme Other
主題 Oxidative stress
キーワード
主題Scheme Other
主題 Oral adsorbent AST-120
抄録
内容記述 Indoxyl sulfate, a uremic toxin, is accumulated in the serum of chronic kidney disease (CKD) patients.A part of the dietary protein-derived tryptophan is metabolized into indole by tryptophanase in intestinal bacteria. Indole is absorbed into the blood from the intestine, and is metabolized to indoxyl sulfate in the liver. Indoxyl sulfate is normally excreted into urine. In CKD, however, an inadequate renal clearance of
indoxyl sulfate leads to its elevated serum levels. The oral adsorbent AST-120 reduces the serum levels of indoxyl sulfate by adsorbing indole in the intestines and stimulating its excretion into feces. I have proposed a protein metabolite theory by which endogenous protein metabolites such as indoxyl sulfate play a significant role in the progression of CKD. A progressive decline in the glomerular filtration rate leads to increased serum levels of endogenous protein metabolites such as indoxyl sulfate, and to the adverse effects of their overload on the remnant nephrons. Indoxyl sulfate stimulates progressive both tubulointerstitial fibrosis and glomerular sclerosis by increasing the expression of transforming growth factor-b1, a tissue inhibitor of metalloproteinase-1 and proa1 (I) collagen, leading to a further loss of
nephrons. AST-120 delays the progression of CKD by removing serum indoxyl sulfate. Moreover, indoxyl sulfate induces oxidative stress in tubular cells, mesangial cells, vascular smooth muscle cells, endothelial cells and osteoblasts as well as stimulating aortic calcification in hypertensive rats, it is also involved in
the progression of CKD, cardiovascular disease (CVD) and osteodystrophy. Thus, the removal of indoxyl sulfate by AST-120 ameliorates the progression of not only CKD, but also of CVD and osteodystrophy.
内容記述タイプ Abstract
出版者
出版者 Nagoya University School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.72.1-2.1
ID登録タイプ JaLC
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
書誌情報 Nagoya Journal of Medical Science

巻 72, 号 1-2, p. 1-11, 発行日 2010-02
フォーマット
application/pdf
著者版フラグ
値 publisher
URI
識別子 http://hdl.handle.net/2237/12904
識別子タイプ HDL
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