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Disruption of Cell Spreading by the Activation of MEK/ERK Pathway is Dependent on AP-1 Activity
https://doi.org/10.18999/nagjms.72.3-4.139
https://doi.org/10.18999/nagjms.72.3-4.139a39fef4c-1ce6-4032-a9a4-d0f9f9384a0d
名前 / ファイル | ライセンス | アクション |
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2010-09-21 | |||||
タイトル | ||||||
タイトル | Disruption of Cell Spreading by the Activation of MEK/ERK Pathway is Dependent on AP-1 Activity | |||||
著者 |
Xu, Feng
× Xu, Feng× Ito, Satoko× Hamaguchi, Michinari× Senga, Takeshi |
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キーワード | ||||||
主題Scheme | Other | |||||
主題 | MEK | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | ERK | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | AP-1 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | BATF | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cell spreading | |||||
抄録 | ||||||
内容記述 | We previously reported that the disruption of cell spreading by v-Crk was dependent on the activation of the MEK/ERK pathway. Here we demonstrate that the activation of that pathway is sufficient to suppress cell spreading. The MEK/ERK pathway regulates the activity of various proteins including AP-1, which is a transcriptional factor composed of heterodimeric proteins. To examine whether AP-1 activity is required for the suppression of cell spreading by the activation of the MEK/ERK pathway, we expressed BATF, which is a negative regulator of AP-1. The expression of BATF clearly restored cell spreading that was suppressed by the activation of MEK/ERK pathway. In addition, a disrupted formation of stress fibers and focal adhesions by such activation was restored by the suppression of AP-1. Our results define an essential role of the MEK/ERK/AP-1 pathway in the disruption of actin cytoskeleton and cell spreading. | |||||
内容記述タイプ | Abstract | |||||
出版者 | ||||||
出版者 | Nagoya University School of Medicine | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
ID登録 | ||||||
ID登録 | 10.18999/nagjms.72.3-4.139 | |||||
ID登録タイプ | JaLC | |||||
ISSN(print) | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0027-7622 | |||||
書誌情報 |
Nagoya Journal of Medical Science 巻 72, 号 3-4, p. 139-144, 発行日 2010-08 |
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フォーマット | ||||||
application/pdf | ||||||
著者版フラグ | ||||||
値 | publisher | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2237/14175 | |||||
識別子タイプ | HDL |