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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 72(3-4)

Preliminary Study on Spontaneous Hepatitis in Long-Evans Cinnamon Rats: A Blood Exchange May Improve the Fetal Hepatitis

https://doi.org/10.18999/nagjms.72.3-4.173
https://doi.org/10.18999/nagjms.72.3-4.173
90fb537c-c7bc-4407-a4ac-c21985ed0e29
名前 / ファイル ライセンス アクション
p173-178_Ueyama.pdf p173-178_Ueyama.pdf (127.9 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2010-09-21
タイトル
タイトル Preliminary Study on Spontaneous Hepatitis in Long-Evans Cinnamon Rats: A Blood Exchange May Improve the Fetal Hepatitis
著者 Ueyama, Jun

× Ueyama, Jun

WEKO 38888

Ueyama, Jun

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Wakusawa, Shinya

× Wakusawa, Shinya

WEKO 38889

Wakusawa, Shinya

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Tatsumi, Yasuyuki

× Tatsumi, Yasuyuki

WEKO 38890

Tatsumi, Yasuyuki

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Hattori, Ai

× Hattori, Ai

WEKO 38891

Hattori, Ai

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Yano, Motoyoshi

× Yano, Motoyoshi

WEKO 38892

Yano, Motoyoshi

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Hayashi, Hisao

× Hayashi, Hisao

WEKO 38893

Hayashi, Hisao

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キーワード
主題Scheme Other
主題 Blood exchange
キーワード
主題Scheme Other
主題 Hepatitis
キーワード
主題Scheme Other
主題 Long-Evans
キーワード
主題Scheme Other
主題 Cinnamon rat
抄録
内容記述 Long-Evans Cinnamon rats are a Wilson disease model highly susceptible to fulminant hepatitis around the age of 20 weeks, and hepatoma over the age of one year. Although prophylaxis has been established for the otherwise fatal hepatitis, effective treatment remains unknown. A blood exchange was tested to determine whether the prognosis of spontaneous hepatitis could be modified in icteric female rats. When bilirubinuria appeared, the rats immediately underwent surgery. Rats under anesthesia were first cannulated into the right atrium via the carotid vein, followed by 2.5 mL of blood exchange with heparinized fresh blood from Long-Evans agouti rats. Treated rats and controls were then observed for 2 months. Compared to the 50% mortality of untreated rats, all icteric rats that received a blood exchange survived the acute episode. We confirmed that Wilson disease animals are highly susceptible to acute hepatitis and show a poor prognosis. However, a single blood exchange improved spontaneous hepatitis in this animal model. This would serve as a first step for establishing a treatment for fatal hepatitis in animals. A blood exchange may improve fulminant hepatitis of Wilson disease model rats.
内容記述タイプ Abstract
出版者
出版者 Nagoya University School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.72.3-4.173
ID登録タイプ JaLC
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
書誌情報 Nagoya Journal of Medical Science

巻 72, 号 3-4, p. 173-177, 発行日 2010-08
フォーマット
application/pdf
著者版フラグ
値 publisher
URI
識別子 http://hdl.handle.net/2237/14180
識別子タイプ HDL
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