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Societies must raise the critical question of whether they can raise such individuals capable of formulating solutions to complex problems confronting them. Universities share the responsibility of raising this question and will need to develop the fundamentals of the abilities and attitudes needed by making maximum utilization of their main resources i.e., academic knowledge, thinking methods, and the faculty. It will be necessary for universities and their faculty to develop educational practices to improve the desired student learning outcomes and the assessment methods of the practices. The steps to \u201cteach the arts of inquiry and innovation\u201dof AAC\u0026U (Association of American College and Universities) may be useful in this regard. Referring to these steps, this study investigates the trials and analyzes the effects of the problem-based learning in large classes. As a result, even in the large class trials, possibilities were observed wherein a teacher can make students think about and answer a big complex question, make them integrate their acquired knowledge, abilities and experiences, and also can make them aware of their learning outcomes. 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