ログイン
言語:

WEKO3

  • トップ
  • ランキング
To
lat lon distance
To

Field does not validate



インデックスリンク

インデックスツリー

メールアドレスを入力してください。

WEKO

One fine body…

WEKO

One fine body…

アイテム

{"_buckets": {"deposit": "86e6b5ae-a217-4328-9cfc-82c6f8f4f413"}, "_deposit": {"id": "13028", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "13028"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00013028", "sets": ["1165"]}, "author_link": ["40966", "40967", "40968", "40969", "40970", "40971", "40972", "40973", "40974", "40975", "40976", "40977", "40978", "40979"], "item_12_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2010-04", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "4", "bibliographicPageEnd": "665", "bibliographicPageStart": "660", "bibliographicVolumeNumber": "31", "bibliographic_titles": [{"bibliographic_title": "Carcinogenesis", "bibliographic_titleLang": "en"}]}]}, "item_12_date_granted_64": {"attribute_name": "学位授与年月日", "attribute_value_mlt": [{"subitem_dategranted": "2010-04-01"}]}, "item_12_degree_grantor_62": {"attribute_name": "学位授与機関", "attribute_value_mlt": [{"subitem_degreegrantor": [{"subitem_degreegrantor_language": "ja", "subitem_degreegrantor_name": "名古屋大学"}, {"subitem_degreegrantor_language": "en", "subitem_degreegrantor_name": "NAGOYA University"}], "subitem_degreegrantor_identifier": [{"subitem_degreegrantor_identifier_name": "13901", "subitem_degreegrantor_identifier_scheme": "kakenhi"}]}]}, "item_12_degree_name_61": {"attribute_name": "学位名", "attribute_value_mlt": [{"subitem_degreename": "博士(医学)", "subitem_degreename_language": "ja"}]}, "item_12_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "The main lifestyle contributor to acetaldehyde exposure is the drinking of alcoholic beverages, but tobacco smoke also makes some contribution. Although acetaldehyde is associated with upper aerodigestive tract cancer risk, in accordance with genetically determined acetaldehyde metabolism, it is unclear whether lung cancer, a representative smoking-related cancer, is associated with acetaldehyde or genes impacting its metabolism. We conducted a case–control study to examine possible interaction between smoking and aldehyde dehydrogenase 2 (ALDH2) Glu504Lys polymorphism (rs671) on the risk of lung cancer in Japanese. Subjects were 718 lung cancer cases and 1416 noncancer controls enrolled in the Hospital-based Epidemiologic Research Program at Aichi Cancer Center. Lifestyle factors, including smoking, were determined by self-administered questionnaire. We applied pack-years (PY; categorized into five levels: never, \u003c15, \u003c30, \u003c45 and ≥45) as a marker of cumulative exposure to smoking. The impact of smoking, ALDH2 genotype, and their interaction on lung cancer risk were assessed by odds ratio (OR) and 95% confidence interval adjusted for potential confounders. Adjusted ORs for PY \u003c15, \u003c30, \u003c45 and ≥45 relative to never smokers among those with Glu/Glu or Glu/Lys were 1.39, 1.80, 3.44 and 6.25, respectively (P-trend = 1.4 × 10^-30). In contrast, ORs among Lys/Lys were 1.01, 10.2, 11.4 and 23.2, respectively (P-trend = 2.6 × 10^-7). Interaction between ALDH2 genotype (Glu/Glu + Glu/Lys versus Lys/Lys) and cumulative smoking dose was statistically significant (P = 0.036) and was consistently observed in the analysis among never-drinkers (interaction P = 0.041). These results suggest that ALDH2 Lys/Lys, a null enzyme activity genotype, modifies the impact of smoking on the risk of lung cancer.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_12_description_5": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "名古屋大学博士学位論文 学位の種類 : 博士(医学)(課程) 学位授与年月日:平成23年3月25日 朴智栄氏の博士論文として提出された", "subitem_description_language": "ja", "subitem_description_type": "Other"}]}, "item_12_dissertation_number_65": {"attribute_name": "学位授与番号", "attribute_value_mlt": [{"subitem_dissertationnumber": "甲第9058号"}]}, "item_12_identifier_60": {"attribute_name": "URI", "attribute_value_mlt": [{"subitem_identifier_type": "DOI", "subitem_identifier_uri": "http://dx.doi.org/10.1093/carcin/bgq021"}, {"subitem_identifier_type": "HDL", "subitem_identifier_uri": "http://hdl.handle.net/2237/14923"}]}, "item_12_publisher_32": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Oxford University Press", "subitem_publisher_language": "en"}]}, "item_12_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1093/carcin/bgq021", "subitem_relation_type_select": "DOI"}}]}, "item_12_rights_12": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "© The Author 2010. Published by Oxford University Press.", "subitem_rights_language": "en"}]}, "item_12_select_15": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_12_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1460-2180", "subitem_source_identifier_type": "EISSN"}]}, "item_12_text_63": {"attribute_name": "学位授与年度", "attribute_value_mlt": [{"subitem_text_value": "2010"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Park, Ji Young", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "40966", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Matsuo, Keitaro", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "40967", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Suzuki, Takeshi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "40968", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ito, Hidemi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "40969", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hosono, Satoyo", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "40970", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kawase, Takakazu", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "40971", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Watanabe, Miki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "40972", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Oze, Isao", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "40973", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hida, Toyoaki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "40974", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yatabe, Yasushi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "40975", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Mitsudomi, Tetsuya", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "40976", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takezaki, Toshiro", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "40977", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tajima, Kazuo", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "40978", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tanaka, Hideo", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "40979", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-02-20"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "k9058.pdf", "filesize": [{"value": "80.0 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 80000.0, "url": {"label": "k9058.pdf", "objectType": "fulltext", "url": "https://nagoya.repo.nii.ac.jp/record/13028/files/k9058.pdf"}, "version_id": "4d99d2fa-7cf9-446c-9877-edad279d4c18"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "doctoral thesis", "resourceuri": "http://purl.org/coar/resource_type/c_db06"}]}, "item_title": "Impact of smoking on lung cancer risk is stronger in those with the homozygous aldehyde dehydrogenase 2 null allele in a Japanese population", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Impact of smoking on lung cancer risk is stronger in those with the homozygous aldehyde dehydrogenase 2 null allele in a Japanese population", "subitem_title_language": "en"}]}, "item_type_id": "12", "owner": "1", "path": ["1165"], "permalink_uri": "http://hdl.handle.net/2237/14923", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2011-06-07"}, "publish_date": "2011-06-07", "publish_status": "0", "recid": "13028", "relation": {}, "relation_version_is_last": true, "title": ["Impact of smoking on lung cancer risk is stronger in those with the homozygous aldehyde dehydrogenase 2 null allele in a Japanese population"], "weko_shared_id": -1}
  1. C100 医学部/医学系研究科
  2. C100d 学位論文
  3. 博士論文(医博・論医博)

Impact of smoking on lung cancer risk is stronger in those with the homozygous aldehyde dehydrogenase 2 null allele in a Japanese population

http://hdl.handle.net/2237/14923
http://hdl.handle.net/2237/14923
5ea272d1-7de5-4844-9a2c-2e29078387e9
名前 / ファイル ライセンス アクション
k9058.pdf k9058.pdf (80.0 kB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2011-06-07
タイトル
タイトル Impact of smoking on lung cancer risk is stronger in those with the homozygous aldehyde dehydrogenase 2 null allele in a Japanese population
言語 en
著者 Park, Ji Young

× Park, Ji Young

WEKO 40966

en Park, Ji Young

Search repository
Matsuo, Keitaro

× Matsuo, Keitaro

WEKO 40967

en Matsuo, Keitaro

Search repository
Suzuki, Takeshi

× Suzuki, Takeshi

WEKO 40968

en Suzuki, Takeshi

Search repository
Ito, Hidemi

× Ito, Hidemi

WEKO 40969

en Ito, Hidemi

Search repository
Hosono, Satoyo

× Hosono, Satoyo

WEKO 40970

en Hosono, Satoyo

Search repository
Kawase, Takakazu

× Kawase, Takakazu

WEKO 40971

en Kawase, Takakazu

Search repository
Watanabe, Miki

× Watanabe, Miki

WEKO 40972

en Watanabe, Miki

Search repository
Oze, Isao

× Oze, Isao

WEKO 40973

en Oze, Isao

Search repository
Hida, Toyoaki

× Hida, Toyoaki

WEKO 40974

en Hida, Toyoaki

Search repository
Yatabe, Yasushi

× Yatabe, Yasushi

WEKO 40975

en Yatabe, Yasushi

Search repository
Mitsudomi, Tetsuya

× Mitsudomi, Tetsuya

WEKO 40976

en Mitsudomi, Tetsuya

Search repository
Takezaki, Toshiro

× Takezaki, Toshiro

WEKO 40977

en Takezaki, Toshiro

Search repository
Tajima, Kazuo

× Tajima, Kazuo

WEKO 40978

en Tajima, Kazuo

Search repository
Tanaka, Hideo

× Tanaka, Hideo

WEKO 40979

en Tanaka, Hideo

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 © The Author 2010. Published by Oxford University Press.
抄録
内容記述 The main lifestyle contributor to acetaldehyde exposure is the drinking of alcoholic beverages, but tobacco smoke also makes some contribution. Although acetaldehyde is associated with upper aerodigestive tract cancer risk, in accordance with genetically determined acetaldehyde metabolism, it is unclear whether lung cancer, a representative smoking-related cancer, is associated with acetaldehyde or genes impacting its metabolism. We conducted a case–control study to examine possible interaction between smoking and aldehyde dehydrogenase 2 (ALDH2) Glu504Lys polymorphism (rs671) on the risk of lung cancer in Japanese. Subjects were 718 lung cancer cases and 1416 noncancer controls enrolled in the Hospital-based Epidemiologic Research Program at Aichi Cancer Center. Lifestyle factors, including smoking, were determined by self-administered questionnaire. We applied pack-years (PY; categorized into five levels: never, <15, <30, <45 and ≥45) as a marker of cumulative exposure to smoking. The impact of smoking, ALDH2 genotype, and their interaction on lung cancer risk were assessed by odds ratio (OR) and 95% confidence interval adjusted for potential confounders. Adjusted ORs for PY <15, <30, <45 and ≥45 relative to never smokers among those with Glu/Glu or Glu/Lys were 1.39, 1.80, 3.44 and 6.25, respectively (P-trend = 1.4 × 10^-30). In contrast, ORs among Lys/Lys were 1.01, 10.2, 11.4 and 23.2, respectively (P-trend = 2.6 × 10^-7). Interaction between ALDH2 genotype (Glu/Glu + Glu/Lys versus Lys/Lys) and cumulative smoking dose was statistically significant (P = 0.036) and was consistently observed in the analysis among never-drinkers (interaction P = 0.041). These results suggest that ALDH2 Lys/Lys, a null enzyme activity genotype, modifies the impact of smoking on the risk of lung cancer.
言語 en
内容記述タイプ Abstract
内容記述
内容記述 名古屋大学博士学位論文 学位の種類 : 博士(医学)(課程) 学位授与年月日:平成23年3月25日 朴智栄氏の博士論文として提出された
言語 ja
内容記述タイプ Other
出版者
言語 en
出版者 Oxford University Press
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_db06
タイプ doctoral thesis
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1093/carcin/bgq021
ISSN
収録物識別子タイプ EISSN
収録物識別子 1460-2180
書誌情報 en : Carcinogenesis

巻 31, 号 4, p. 660-665, 発行日 2010-04
学位名
言語 ja
学位名 博士(医学)
学位授与機関
学位授与機関識別子Scheme kakenhi
学位授与機関識別子 13901
言語 ja
学位授与機関名 名古屋大学
言語 en
学位授与機関名 NAGOYA University
学位授与年度
学位授与年度 2010
学位授与年月日
学位授与年月日 2010-04-01
学位授与番号
学位授与番号 甲第9058号
著者版フラグ
値 publisher
URI
識別子 http://dx.doi.org/10.1093/carcin/bgq021
識別子タイプ DOI
URI
識別子 http://hdl.handle.net/2237/14923
識別子タイプ HDL
戻る
0
views
See details
Views

Versions

Ver.1 2021-03-01 18:41:07.408579
Show All versions

Share

Mendeley Twitter Facebook Print Addthis

Cite as

エクスポート

OAI-PMH
  • OAI-PMH JPCOAR
  • OAI-PMH DublinCore
  • OAI-PMH DDI
Other Formats
  • JSON
  • BIBTEX

Confirm


Powered by WEKO3


Powered by WEKO3