{"_buckets": {"deposit": "86e6b5ae-a217-4328-9cfc-82c6f8f4f413"}, "_deposit": {"id": "13028", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "13028"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00013028"}, "item_12_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2010-04", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "4", "bibliographicPageEnd": "665", "bibliographicPageStart": "660", "bibliographicVolumeNumber": "31", "bibliographic_titles": [{"bibliographic_title": "Carcinogenesis"}]}]}, "item_12_date_granted_64": {"attribute_name": "\u5b66\u4f4d\u6388\u4e0e\u5e74\u6708\u65e5", "attribute_value_mlt": [{"subitem_dategranted": "2010-04-01"}]}, "item_12_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "The main lifestyle contributor to acetaldehyde exposure is the drinking of alcoholic beverages, but tobacco smoke also makes some contribution. Although acetaldehyde is associated with upper aerodigestive tract cancer risk, in accordance with genetically determined acetaldehyde metabolism, it is unclear whether lung cancer, a representative smoking-related cancer, is associated with acetaldehyde or genes impacting its metabolism. We conducted a case\u2013control study to examine possible interaction between smoking and aldehyde dehydrogenase 2 (ALDH2) Glu504Lys polymorphism (rs671) on the risk of lung cancer in Japanese. Subjects were 718 lung cancer cases and 1416 noncancer controls enrolled in the Hospital-based Epidemiologic Research Program at Aichi Cancer Center. Lifestyle factors, including smoking, were determined by self-administered questionnaire. We applied pack-years (PY; categorized into five levels: never, \u003c15, \u003c30, \u003c45 and \u226545) as a marker of cumulative exposure to smoking. The impact of smoking, ALDH2 genotype, and their interaction on lung cancer risk were assessed by odds ratio (OR) and 95% confidence interval adjusted for potential confounders. Adjusted ORs for PY \u003c15, \u003c30, \u003c45 and \u226545 relative to never smokers among those with Glu/Glu or Glu/Lys were 1.39, 1.80, 3.44 and 6.25, respectively (P-trend \uff1d 1.4 \u00d7 10^-30). In contrast, ORs among Lys/Lys were 1.01, 10.2, 11.4 and 23.2, respectively (P-trend \uff1d 2.6 \u00d7 10^-7). Interaction between ALDH2 genotype (Glu/Glu \uff0b Glu/Lys versus Lys/Lys) and cumulative smoking dose was statistically significant (P \uff1d 0.036) and was consistently observed in the analysis among never-drinkers (interaction P \uff1d 0.041). These results suggest that ALDH2 Lys/Lys, a null enzyme activity genotype, modifies the impact of smoking on the risk of lung cancer.", "subitem_description_type": "Abstract"}]}, "item_12_description_5": {"attribute_name": "\u5185\u5bb9\u8a18\u8ff0", "attribute_value_mlt": [{"subitem_description": "\u540d\u53e4\u5c4b\u5927\u5b66\u535a\u58eb\u5b66\u4f4d\u8ad6\u6587 \u5b66\u4f4d\u306e\u7a2e\u985e : \u535a\u58eb(\u533b\u5b66)(\u8ab2\u7a0b) \u5b66\u4f4d\u6388\u4e0e\u5e74\u6708\u65e5:\u5e73\u621023\u5e743\u670825\u65e5 \u6734\u667a\u6804\u6c0f\u306e\u535a\u58eb\u8ad6\u6587\u3068\u3057\u3066\u63d0\u51fa\u3055\u308c\u305f", "subitem_description_type": "Other"}]}, "item_12_dissertation_number_65": {"attribute_name": "\u5b66\u4f4d\u6388\u4e0e\u756a\u53f7", "attribute_value_mlt": [{"subitem_dissertationnumber": "13901\u7532\u7b2c9058\u53f7"}]}, "item_12_identifier_60": {"attribute_name": "URI", "attribute_value_mlt": [{"subitem_identifier_type": "DOI", "subitem_identifier_uri": "http://dx.doi.org/10.1093/carcin/bgq021"}, {"subitem_identifier_type": "HDL", "subitem_identifier_uri": "http://hdl.handle.net/2237/14923"}]}, "item_12_publisher_32": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Oxford University Press"}]}, "item_12_rights_12": {"attribute_name": "\u6a29\u5229", "attribute_value_mlt": [{"subitem_rights": "\u00a9 The Author 2010. Published by Oxford University Press."}]}, "item_12_select_15": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_12_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1460-2180", "subitem_source_identifier_type": "ISSN"}]}, "item_12_text_63": {"attribute_name": "\u5b66\u4f4d\u6388\u4e0e\u5e74\u5ea6", "attribute_value_mlt": [{"subitem_text_value": "2010"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Park, Ji Young"}], "nameIdentifiers": [{"nameIdentifier": "40966", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Matsuo, Keitaro"}], "nameIdentifiers": [{"nameIdentifier": "40967", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Suzuki, Takeshi"}], "nameIdentifiers": [{"nameIdentifier": "40968", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ito, Hidemi"}], "nameIdentifiers": [{"nameIdentifier": "40969", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hosono, Satoyo"}], "nameIdentifiers": [{"nameIdentifier": "40970", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kawase, Takakazu"}], "nameIdentifiers": [{"nameIdentifier": "40971", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Watanabe, Miki"}], "nameIdentifiers": [{"nameIdentifier": "40972", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Oze, Isao"}], "nameIdentifiers": [{"nameIdentifier": "40973", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hida, Toyoaki"}], "nameIdentifiers": [{"nameIdentifier": "40974", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yatabe, Yasushi"}], "nameIdentifiers": [{"nameIdentifier": "40975", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Mitsudomi, Tetsuya"}], "nameIdentifiers": [{"nameIdentifier": "40976", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takezaki, Toshiro"}], "nameIdentifiers": [{"nameIdentifier": "40977", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tajima, Kazuo"}], "nameIdentifiers": [{"nameIdentifier": "40978", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tanaka, Hideo"}], "nameIdentifiers": [{"nameIdentifier": "40979", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-02-20"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "k9058.pdf", "filesize": [{"value": "80.0 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 80000.0, "url": {"label": "k9058.pdf", "url": "https://nagoya.repo.nii.ac.jp/record/13028/files/k9058.pdf"}, "version_id": "4d99d2fa-7cf9-446c-9877-edad279d4c18"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "thesis", "resourceuri": "http://purl.org/coar/resource_type/c_46ec"}]}, "item_title": "Impact of smoking on lung cancer risk is stronger in those with the homozygous aldehyde dehydrogenase 2 null allele in a Japanese population", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Impact of smoking on lung cancer risk is stronger in those with the homozygous aldehyde dehydrogenase 2 null allele in a Japanese population"}]}, "item_type_id": "12", "owner": "1", "path": ["499/960/1165"], "permalink_uri": "http://hdl.handle.net/2237/14923", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2011-06-07"}, "publish_date": "2011-06-07", "publish_status": "0", "recid": "13028", "relation": {}, "relation_version_is_last": true, "title": ["Impact of smoking on lung cancer risk is stronger in those with the homozygous aldehyde dehydrogenase 2 null allele in a Japanese population"], "weko_shared_id": null}