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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 73(3-4)

A CASE OF AUTOIMMUNE HEPATITIS WITH GRAVES’ DISEASE TREATED BY PROPYLTHIOURACIL

https://doi.org/10.18999/nagjms.73.3-4.205
https://doi.org/10.18999/nagjms.73.3-4.205
e23f3ae0-f583-4bc4-9312-3efe8aed78c9
名前 / ファイル ライセンス アクション
v73n34p205_209.pdf v73n34p205_209.pdf (356.5 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2011-08-25
タイトル
タイトル A CASE OF AUTOIMMUNE HEPATITIS WITH GRAVES’ DISEASE TREATED BY PROPYLTHIOURACIL
言語 en
著者 SATO, IKUKO

× SATO, IKUKO

WEKO 42257

en SATO, IKUKO

Search repository
TSUNEKAWA, TAKU

× TSUNEKAWA, TAKU

WEKO 42258

en TSUNEKAWA, TAKU

Search repository
SHINOHARA, YURI

× SHINOHARA, YURI

WEKO 42259

en SHINOHARA, YURI

Search repository
NISHIO, YUICHIRO

× NISHIO, YUICHIRO

WEKO 42260

en NISHIO, YUICHIRO

Search repository
SHIMIZU, YUKO

× SHIMIZU, YUKO

WEKO 42261

en SHIMIZU, YUKO

Search repository
SUZUKI, YASUHIKO

× SUZUKI, YASUHIKO

WEKO 42262

en SUZUKI, YASUHIKO

Search repository
YOSHIOKA, SHUKO

× YOSHIOKA, SHUKO

WEKO 42263

en YOSHIOKA, SHUKO

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
キーワード
主題Scheme Other
主題 Graves’ disease
キーワード
主題Scheme Other
主題 Propylthiouracil
キーワード
主題Scheme Other
主題 Autoimmune hepatitis
抄録
内容記述 A 58-year-old woman was referred to our hospital because of liver dysfunction. Her serum levels of AST (619 IU/l) and ALT (603 IU/l) had increased. Histological findings in the liver biopsy were compatible to autoimmune hepatitis (AIH), and the diagnosis of AIH was confirmed by the diagnostic criteria. She was admitted to a nearby hospital 3 years ago, and diagnosed with Graves’ disease. She received methimazole (MMI) at first, which was discontinued due to liver injury in one month, then propylthiouracil (PTU) was administered. One year later, transaminase increased and was decreased by stopping PTU administration. PTU was restarted after her transaminase decreased, but a recurrence of hepatotoxicity was observed, and she was referred to our hospital. Oral prednisolone decreased liver function immediately. In this case, PTU-induced liver injury was suspected as a possible trigger of AIH. While PTU remains a commonly used drug in the treatment of hyperthyroidism, severe liver injury is reported in some cases. If liver injury is observed in patients treated with PTU, rechallenge is not recommended in order to avoid severe hepatotoxicity.
言語 en
内容記述タイプ Abstract
出版者
言語 en
出版者 Nagoya University School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
ID登録
ID登録 10.18999/nagjms.73.3-4.205
ID登録タイプ JaLC
ISSN(print)
収録物識別子タイプ PISSN
収録物識別子 0027-7622
ISSN(Online)
収録物識別子タイプ EISSN
収録物識別子 2186-3326
書誌情報 en : Nagoya Journal of Medical Science

巻 73, 号 3-4, p. 205-209, 発行日 2011-08
著者版フラグ
値 publisher
URI
識別子 http://hdl.handle.net/2237/15363
識別子タイプ HDL
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