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  1. F100 環境医学研究所
  2. F100b 紀要
  3. Environmental medicine : annual report of the Research Institute of Environmental Medicine
  4. 46(1-2)

Neuronal Migration and Neuronal Migration Disorder in Cerebral Cortex

https://doi.org/10.18999/envm.46.7
https://doi.org/10.18999/envm.46.7
c1271166-455c-407b-a021-50ea62823cb2
名前 / ファイル ライセンス アクション
KJ00000034853.pdf KJ00000034853.pdf (2.6 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2006-01-05
タイトル
タイトル Neuronal Migration and Neuronal Migration Disorder in Cerebral Cortex
言語 en
著者 SUN, Xue-Zhi

× SUN, Xue-Zhi

WEKO 3075

en SUN, Xue-Zhi

Search repository
TAKAHASHI, Sentaro

× TAKAHASHI, Sentaro

WEKO 3076

en TAKAHASHI, Sentaro

Search repository
GUI, Chun

× GUI, Chun

WEKO 3077

en GUI, Chun

Search repository
ZHANG, Rui

× ZHANG, Rui

WEKO 3078

en ZHANG, Rui

Search repository
KOGA, Kazuo

× KOGA, Kazuo

WEKO 3079

en KOGA, Kazuo

Search repository
NOUYE, Minoru

× NOUYE, Minoru

WEKO 3080

en NOUYE, Minoru

Search repository
MURATA, Yoshiharu

× MURATA, Yoshiharu

WEKO 3081

en MURATA, Yoshiharu

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
キーワード
主題Scheme Other
主題 cell migration
キーワード
主題Scheme Other
主題 cerebrum
キーワード
主題Scheme Other
主題 heterotopic mass
キーワード
主題Scheme Other
主題 radial glial cel
キーワード
主題Scheme Other
主題 ventricular zone
抄録
内容記述 Neuronal cell migration is one of the most significant features during cortical development. After final mitosis, neurons migrate from the ventricular zone into the cortical plate, and then establish neuronal lamina and settle onto the outermost layer, forming an "inside-out" gradient of maturation. Neuronal migration is guided by radial glial fibers and also needs proper receptors, ligands, and other unknown extracellular factors, requests local signaling (e.g. some emitted by the Cajal-Retzius cells of the marginal zone) to stop neuronal migration. This process is highly sensitive to various physical, chemical and biological agents as well as to genetic mutations. Any disturbance of the normal process may result in neuronal migration disorder. Such neuronal migration disorder is believed as major cause of both gross brain malformation and more special cerebral structural and functional abnormalities in experimental animals and in humans. A number of instructive studies on nongenetic models (e.g. MAM- or irradiation-treated rodents) and mutations (e.g. Reelin- or Tish-mutant animals) have established the foundation of cortex formation and provided a framework in which to understand mutants of cortex development. The recent studies on several genetic model systems of neuronal migration disorder provide further insight into the development pathways that underlie normal and abnormal neuronal migration.
言語 en
内容記述タイプ Abstract
内容記述
内容記述 国立情報学研究所で電子化したコンテンツを使用している。
言語 ja
内容記述タイプ Other
出版者
言語 en
出版者 Research Institute of Environmental Medicine, Nagoya University
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
ID登録
ID登録 10.18999/envm.46.7
ID登録タイプ JaLC
ISSN(print)
収録物識別子タイプ PISSN
収録物識別子 02870517
書誌情報 en : Environmental medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University

巻 46, 号 1/2, p. 7-15, 発行日 2002-12
フォーマット
application/pdf
著者版フラグ
値 publisher
URI
識別子 http://hdl.handle.net/2237/2773
識別子タイプ HDL
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