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Neuronal Migration and Neuronal Migration Disorder in Cerebral Cortex
https://doi.org/10.18999/envm.46.7
https://doi.org/10.18999/envm.46.7c1271166-455c-407b-a021-50ea62823cb2
名前 / ファイル | ライセンス | アクション |
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KJ00000034853.pdf (2.6 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2006-01-05 | |||||
タイトル | ||||||
タイトル | Neuronal Migration and Neuronal Migration Disorder in Cerebral Cortex | |||||
言語 | en | |||||
著者 |
SUN, Xue-Zhi
× SUN, Xue-Zhi× TAKAHASHI, Sentaro× GUI, Chun× ZHANG, Rui× KOGA, Kazuo× NOUYE, Minoru× MURATA, Yoshiharu |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | cell migration | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | cerebrum | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | heterotopic mass | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | radial glial cel | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | ventricular zone | |||||
抄録 | ||||||
内容記述 | Neuronal cell migration is one of the most significant features during cortical development. After final mitosis, neurons migrate from the ventricular zone into the cortical plate, and then establish neuronal lamina and settle onto the outermost layer, forming an "inside-out" gradient of maturation. Neuronal migration is guided by radial glial fibers and also needs proper receptors, ligands, and other unknown extracellular factors, requests local signaling (e.g. some emitted by the Cajal-Retzius cells of the marginal zone) to stop neuronal migration. This process is highly sensitive to various physical, chemical and biological agents as well as to genetic mutations. Any disturbance of the normal process may result in neuronal migration disorder. Such neuronal migration disorder is believed as major cause of both gross brain malformation and more special cerebral structural and functional abnormalities in experimental animals and in humans. A number of instructive studies on nongenetic models (e.g. MAM- or irradiation-treated rodents) and mutations (e.g. Reelin- or Tish-mutant animals) have established the foundation of cortex formation and provided a framework in which to understand mutants of cortex development. The recent studies on several genetic model systems of neuronal migration disorder provide further insight into the development pathways that underlie normal and abnormal neuronal migration. | |||||
言語 | en | |||||
内容記述タイプ | Abstract | |||||
内容記述 | ||||||
内容記述 | 国立情報学研究所で電子化したコンテンツを使用している。 | |||||
言語 | ja | |||||
内容記述タイプ | Other | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | Research Institute of Environmental Medicine, Nagoya University | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
ID登録 | ||||||
ID登録 | 10.18999/envm.46.7 | |||||
ID登録タイプ | JaLC | |||||
ISSN(print) | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 02870517 | |||||
書誌情報 |
en : Environmental medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University 巻 46, 号 1/2, p. 7-15, 発行日 2002-12 |
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フォーマット | ||||||
application/pdf | ||||||
著者版フラグ | ||||||
値 | publisher | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2237/2773 | |||||
識別子タイプ | HDL |