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  1. F100 環境医学研究所
  2. F100b 紀要
  3. Environmental medicine : annual report of the Research Institute of Environmental Medicine
  4. 46(1-2)

Cyclosporin A (CsA)-sensitive Pathway for the Induction of ZAKI-4 Expression by Thyroid Hormone

https://doi.org/10.18999/envm.46.40
https://doi.org/10.18999/envm.46.40
dd6f0e2a-b064-44f2-bbc1-7affaa8ff25f
名前 / ファイル ライセンス アクション
KJ00000034858.pdf KJ00000034858.pdf (549.6 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2006-01-05
タイトル
タイトル Cyclosporin A (CsA)-sensitive Pathway for the Induction of ZAKI-4 Expression by Thyroid Hormone
言語 en
著者 CAO, Xia

× CAO, Xia

WEKO 3103

en CAO, Xia

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KAMBE, Fukushi

× KAMBE, Fukushi

WEKO 3104

en KAMBE, Fukushi

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SEO, Hisao

× SEO, Hisao

WEKO 3105

en SEO, Hisao

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
キーワード
主題Scheme Other
主題 ZAKI-4
キーワード
主題Scheme Other
主題 calcineurin
キーワード
主題Scheme Other
主題 CsA
キーワード
主題Scheme Other
主題 FK506
キーワード
主題Scheme Other
主題 thyroid hormone
抄録
内容記述 We identified ZAKI-4 as a thyroid hormone (T3) responsive gene in human skin fibroblasts. Our recent study revealed that two ZAKI-4 isoforms, α and β, are generated from a single gene on chromosome 6. Only expression of α is increased by T3, while that of β is not affected. Both isoforms belong to a family of proteins containing a conserved motif, which interacts with calcineurin and inhibits its activity. Recently, expression of a mouse homologue of the ZAKI-4 family gene (MCIP1) is shown to be induced by the activation of calcineurin in myocytes. We thus studied whether ZAKI-4 expression is also regulated by calcineurin-mediated pathway. Northern blot analysis revealed activation of calcineurin by ionomycin/phorbol 12-myristate 13-acetate (PMA) did not increase the expression of both isoforms. In addition, either basal expression of the two isoforms or T3-induced ZAKI-4α expression was not affected by FK506, a specific calcineurin inhibitor, suggesting the activation of calcineurin is not involved in ZAKI-4 regulation. However, cyclosporin A (CsA), another inhibitor of calcineurin decreased the basal expression of ZAKI-4α. Furthermore, T3-mediated increase of ZAKI-4α was completely blocked by CsA, but not by FK506. It is thus indicated that the two isoforms are differentially regulated, and the regulation of ZAKI-4α involves a CsA-sensitive pathway, which is independent of calcineurin activation.
言語 en
内容記述タイプ Abstract
内容記述
内容記述 国立情報学研究所で電子化したコンテンツを使用している。
言語 ja
内容記述タイプ Other
出版者
言語 en
出版者 Research Institute of Environmental Medicine, Nagoya University
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
ID登録
ID登録 10.18999/envm.46.40
ID登録タイプ JaLC
ISSN(print)
収録物識別子タイプ PISSN
収録物識別子 02870517
書誌情報 en : Environmental medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University

巻 46, 号 1/2, p. 40-42, 発行日 2002-12
フォーマット
application/pdf
著者版フラグ
値 publisher
URI
識別子 http://hdl.handle.net/2237/2778
識別子タイプ HDL
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