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A specific Translocation of Chromosome 3 Generating Pax8-PPARg Fusion mRNA is Rare in Japanese Patients with Follicular Carcinoma
https://doi.org/10.18999/envm.46.45
https://doi.org/10.18999/envm.46.45ee6e343c-10b2-4e11-9a8f-2ca0525bb087
名前 / ファイル | ライセンス | アクション |
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KJ00000034860.pdf (376.9 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2006-01-05 | |||||
タイトル | ||||||
タイトル | A specific Translocation of Chromosome 3 Generating Pax8-PPARg Fusion mRNA is Rare in Japanese Patients with Follicular Carcinoma | |||||
言語 | en | |||||
著者 |
HIBI, Yatsuka
× HIBI, Yatsuka× NAGAYA, Takashi× KAMBE, Fukushi× IMAI, Tsuneo× FUNAHASHI, Hiroomi× SEO, Hisao |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Pax8 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | PPARγ | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | thyroid | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | follicular carcinoma | |||||
抄録 | ||||||
内容記述 | Thyroid follicular neoplasm is commonly encountered in clinical medicine. However, it is difficult to pathologically differentiate benign from malignant tumors. Recently t (2,3)(ql3; p25), a translocation resulting in the generation of Pax8-PPARγ fusion gene has been reported in American patients with follicular carcinoma with high incidence suggesting that Pax8-PPARγ fusion mRNA could be a molecular marker for the diagnosis of follicular carcinoma. In this study we examined the expression of this fusion gene in follicular carcinomas in Japanese patients. Various thyroid nodules (follicular carcinoma, follicular adenoma, papillary carcinoma, adenomatous goiter and normal tissue) were obtained at surgery in our institute and total RNAs were used to detect the Pax8-PPARγ fusion mRNA by RT-PCR. In all the follicular carcinoma samples, Pax8-PPARγ fusion mRNA was not detected. In all the other samples the expression was also negative. On the other hand, wild type Pax8 mRNA was detected in all the samples and wild type PPARγ mRNA was detected in 83.3% of the follicular adenoma and the adenomatous goiter samples, in 100% of the follicular carcinoma, the papillary carcinoma and the normal tissue samples respectively. In contrast to the previous report, no expression of Pax8-PPARγ fusion gene was detected in follicular carcinomas. Ethnic background may affect the translocation on the pathogenesis. | |||||
言語 | en | |||||
内容記述タイプ | Abstract | |||||
内容記述 | ||||||
内容記述 | 国立情報学研究所で電子化したコンテンツを使用している。 | |||||
言語 | ja | |||||
内容記述タイプ | Other | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | Research Institute of Environmental Medicine, Nagoya University | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
ID登録 | ||||||
ID登録 | 10.18999/envm.46.45 | |||||
ID登録タイプ | JaLC | |||||
ISSN(print) | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 02870517 | |||||
書誌情報 |
en : Environmental medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University 巻 46, 号 1/2, p. 45-47, 発行日 2002-12 |
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フォーマット | ||||||
application/pdf | ||||||
著者版フラグ | ||||||
値 | publisher | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2237/2780 | |||||
識別子タイプ | HDL |